Advances in Friedel Crafts Acylation Reactions

Advances in Friedel Crafts Acylation Reactions

This book focuses on how to make this reaction more economically and environmentally friendly by using green acylating conditions, minimizing the formation of waste and decreasing production costs.

Author: Giovanni Sartori

Publisher: CRC Press

ISBN: 1138113840

Category:

Page: 216

View: 586

Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. Nearly 40 years since the last major treatise on the topic and reflecting the growing emphasis on green technology, Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processesfocuses on how to make this reaction more economically and environmentally friendly by using green acylating conditions, thus minimizing the formation of waste and decreasing production costs. Divided into four parts, the book explores stoichiometric acylations, catalytic homogeneous acylations, catalytic heterogeneous acylations, and phenol acylations. It is structured according to the role played by the catalyst in the activation of reagents as well as in the different modes of regioselectivity encountered in the acylation of arenes, aromatic ethers, and phenols. Incorporating examples of all acid-catalyzed Friedel-Crafts acylation reactions, the text considers classic Lewis and Brönsted acid types along with more innovative and advanced multicomponent superacid catalysts. These range from rare earth triflates or triflimides and their combination with ionic liquids to metal-promoted zeolites and zeotypes, clays, polymetal oxides, sulfated zirconia, heteropoly acids, and Nafion. The book emphasizes the major industrial applications, providing a critical assessment of the differences, advantages, and disadvantages of homogeneous and heterogeneous catalysis. Helping readers to better understand the mechanism of the Friedel-Crafts acylation, the examples in the book substantiate the development of more effective catalysts and more selective processes achieved during the last few decades, enabling industry to embark on a safer and more efficient synthesis of aromatic ketones for the manufacture of a wide array of products.
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Advances in Friedel Crafts Acylation Reactions

Advances in Friedel Crafts Acylation Reactions

Catalytic and Green Processes Giovanni Sartori, Raimondo Maggi. Advances in. FriedelCrafts. Acylation. Reactions. Catalytic. and. Green. Processes. Used in the production of a wide number of fine chemicals and pharmaceuticals, ...

Author: Giovanni Sartori

Publisher: CRC Press

ISBN: 1420067931

Category: Science

Page: 216

View: 531

Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. Nearly 40 years since the last major treatise on the topic and reflecting the growing emphasis on green technology, Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes focuses on how to make this reaction more economically and environmentally friendly by using green acylating conditions, thus minimizing the formation of waste and decreasing production costs. Divided into four parts, the book explores stoichiometric acylations, catalytic homogeneous acylations, catalytic heterogeneous acylations, and phenol acylations. It is structured according to the role played by the catalyst in the activation of reagents as well as in the different modes of regioselectivity encountered in the acylation of arenes, aromatic ethers, and phenols. Incorporating examples of all acid-catalyzed Friedel-Crafts acylation reactions, the text considers classic Lewis and Brönsted acid types along with more innovative and advanced multicomponent superacid catalysts. These range from rare earth triflates or triflimides and their combination with ionic liquids to metal-promoted zeolites and zeotypes, clays, polymetal oxides, sulfated zirconia, heteropoly acids, and Nafion. The book emphasizes the major industrial applications, providing a critical assessment of the differences, advantages, and disadvantages of homogeneous and heterogeneous catalysis. Helping readers to better understand the mechanism of the Friedel-Crafts acylation, the examples in the book substantiate the development of more effective catalysts and more selective processes achieved during the last few decades, enabling industry to embark on a safer and more efficient synthesis of aromatic ketones for the manufacture of a wide array of products.
Categories: Science

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science

Conclusions The prominent features of alkylation reactions in sonication are clean, mild, selective, and efficient for many ... [18] G. Sartori, R. Maggi, Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes, ...

Author: Dr Inamuddin

Publisher: Elsevier

ISBN: 9780128227596

Category: Technology & Engineering

Page: 382

View: 462

Green Sustainable Process for Chemical and Environmental Engineering and Science: Sonochemical Organic Synthesis focuses on purification and extraction of organic, biological, and medicinal compounds using sonochemistry. It provides readers with an understanding of green ultrasound-assisted chemical synthesis for industrial applications. This book systematically explores the application of ultrasound in organic synthesis of all types and includes stereoselectivity, regioselectivity, oxidations, reductions, protection, deprotection, additions, condensation, coupling, C-X bond formation, named reactions, heterocyclics, biological drugs, and fluoroorganics over conventional techniques. A brief introduction to the parameters which influence the process, solvent-effects, supported reagents and catalysis and the pros and cons to the practical use of sonochemical protocols in organic synthesis are also discussed. This book provides overview on the applications of sonochemical technology for the sustainable and environmentally friendly development of synthetic methodologies for organic and pharmaceutical chemistry. Sonochemical Organic Synthesis is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in modern organic chemistry and medicinal chemistry. Offers a broad overview of ultrasonics-assisted green organic synthesis Discusses sonochemical technology for green organic synthesis and biological medicinal importance Gives detailed accounts of numerous industrial applications, including polymers, pharmaceutical, fluoroorganics, biofuel, carbon, and more Includes a description of significant factors and challenges in ultrasonics-assisted green organic synthesis Lists recent developments in the use of sonochemical technology in organic chemist
Categories: Technology & Engineering

Greener Organic Transformations

Greener Organic Transformations

M. C. Cann and M. E. Connelly, Real- world Cases in Green Chemistry, American Chemical Society, 2000, pp. ... G. Sartori and R. Maggi, Advances in Friedel- Crafts Acylation Reactions: Catalytic and Green Processes, CRC Press, 1st edn, ...

Author: James H. Clark

Publisher: Royal Society of Chemistry

ISBN: 9781788012034

Category: Science

Page: 205

View: 812

Green chemistry has progressed from being a driver for change in the chemical and allied industries to being a critical part of chemical education at all levels. The future chemist must be able to practice their trade in the light of increasing concerns about waste and resources, the safety of chemicals in consumer products, and increasingly restrictive legislation. While there are green chemistry educational resources available including lectures and experiments as well as numerous books on green chemistry and major green chemical technologies, there is no "green equivalent" of a standard organic chemistry textbook Systematically covering a variety of well-known reactions that commonly feature in standard organic textbooks this book supplements and supports the standard organic chemistry texts. It highlights the main sustainability issues of classical and contemporary organic transformations and critically evaluates them within a metric of established Green Chemistry Principles noting where additional efforts are needed to improve their environmental footprint. Written by a team of expert authors with a multinational advisory board, this book is a fantastic resource for advanced undergraduate and postgraduate students worldwide.
Categories: Science

March s Advanced Organic Chemistry

March s Advanced Organic Chemistry

Reactions, Mechanisms, and Structure Michael B. Smith ... Also see Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes, Sartori, G.; Maggi, R., CRC Press, Boca Raton, FL. 2009. 478 For a list of reagents, ...

Author: Michael B. Smith

Publisher: John Wiley & Sons

ISBN: 9781119371809

Category: Science

Page: 2144

View: 696

The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.
Categories: Science

Carbocation Chemistry

Carbocation Chemistry

Olah, G. A.; Krishnamurti, R.; Prakash, G. K. S. In FriedelCrafts Alkylation in Comprehensive Organic Synthesis, Vol. ... Sartori, G.; Maggi, R. Advances in FriedelCrafts Acylation Reactions: Catalytic and Green Processes, ...

Author: Jie Jack Li

Publisher: CRC Press

ISBN: 9781315353197

Category: Medical

Page: 208

View: 166

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications. This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.
Categories: Medical

Applied Biocatalysis

Applied Biocatalysis

The reaction was stopped by acidification (pH∼1.0) with aqueous HCl (6M). ... 11, 300–301; (c) Sartori, G. and Maggi, R. (2009) Advances in FriedelCrafts Acylation Reactions: Catalytic and Green Processes, CRC Press. 2.

Author: John Whittall

Publisher: John Wiley & Sons

ISBN: 9781119487012

Category: Science

Page: 560

View: 761

Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.
Categories: Science

Arene Chemistry

Arene Chemistry

Reaction Mechanisms and Methods for Aromatic Compounds Jacques Mortier ... (b) Sartori, G., Maggi, R. (2009) Advances in FriedelCrafts Acylation Reactions Catalytic and Green Processes, CRC Press, Boca Raton, FL.

Author: Jacques Mortier

Publisher: John Wiley & Sons

ISBN: 9781118754955

Category: Science

Page: 992

View: 668

Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. • Surveys methods used for preparing arene compounds and their transformations • Connects reactivity and methodology with mechanism • Helps readers apply aromatic reactions in a practical context by designing syntheses • Provides essential information about techniques used to determine reaction mechanisms
Categories: Science

Organic Syntheses Volume 95

Organic Syntheses  Volume 95

2, p 753–768; (f) Sartori, G.; Maggi, R. Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes; CRC Press: Boca Raton, 2010. 4. (a) Pearson, D. E.; Buehler, C. A. Synthesis 1972, 1972, 533–542; (b) Sartori, G.; ...

Author: Brian M. Stoltz

Publisher: John Wiley & Sons

ISBN: 9781119595397

Category: Science

Page: 592

View: 163

The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.
Categories: Science

Organic Reaction Mechanisms 2010

Organic Reaction Mechanisms 2010

74 Sartori, G.and Maggi, R., Advances in FriedelCrafts Acylation Reactions: Catalytic and Green Processes, CRC Press, Boca Raton, FL, 2009. 75 Taylor, J. E., Jones, M.D., Williams, J.M. T., and Bull,S. P., Org. Lett., 12, 5740 (2010).

Author: A. C. Knipe

Publisher: John Wiley & Sons

ISBN: 9781119943570

Category: Science

Page: 656

View: 578

Organic Reaction Mechanisms 2010, the 46th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2010. It details the latest progress in a wide range of classes of organic reaction mechanisms, including reactions of different compounds and acids and their derivatives, oxidation and reduction, aliphatic substitutions, elimination reactions, and molecular rearrangements, to name a few. An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
Categories: Science