Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry.
Author: Giovanni Sartori
Publisher: CRC Press
Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. Nearly 40 years since the last major treatise on the topic and reflecting the growing emphasis on green technology, Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes focuses on how to make this reaction more economically and environmentally friendly by using green acylating conditions, thus minimizing the formation of waste and decreasing production costs. Divided into four parts, the book explores stoichiometric acylations, catalytic homogeneous acylations, catalytic heterogeneous acylations, and phenol acylations. It is structured according to the role played by the catalyst in the activation of reagents as well as in the different modes of regioselectivity encountered in the acylation of arenes, aromatic ethers, and phenols. Incorporating examples of all acid-catalyzed Friedel-Crafts acylation reactions, the text considers classic Lewis and Brönsted acid types along with more innovative and advanced multicomponent superacid catalysts. These range from rare earth triflates or triflimides and their combination with ionic liquids to metal-promoted zeolites and zeotypes, clays, polymetal oxides, sulfated zirconia, heteropoly acids, and Nafion. The book emphasizes the major industrial applications, providing a critical assessment of the differences, advantages, and disadvantages of homogeneous and heterogeneous catalysis. Helping readers to better understand the mechanism of the Friedel-Crafts acylation, the examples in the book substantiate the development of more effective catalysts and more selective processes achieved during the last few decades, enabling industry to embark on a safer and more efficient synthesis of aromatic ketones for the manufacture of a wide array of products.
M. C. Cann and M. E. Connelly, Real- world Cases in Green Chemistry, American Chemical Society, 2000, pp. ... G. Sartori and R. Maggi, Advances in Friedel- Crafts Acylation Reactions: Catalytic and Green Processes, CRC Press, 1st edn, ...
Author: James H. Clark
Publisher: Royal Society of Chemistry
Green chemistry has progressed from being a driver for change in the chemical and allied industries to being a critical part of chemical education at all levels. Future Chemists must be able to practice their trade in the light of increasing concerns about waste and resources, the safety of chemicals in consumer products, and increasingly restrictive legislation. Covering a variety of well-known reactions that commonly feature in standard organic textbooks this book supplements and supports the standard organic chemistry texts.
Reactions, Mechanisms, and Structure Michael B. Smith ... Also see Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes, Sartori, G.; Maggi, R., CRC Press, Boca Raton, FL. 2009. 478 For a list of reagents, ...
Author: Michael B. Smith
Publisher: John Wiley & Sons
The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields.
The reaction was stopped by acidification (pH∼1.0) with aqueous HCl (6M). ... 11, 300–301; (c) Sartori, G. and Maggi, R. (2009) Advances in Friedel–Crafts Acylation Reactions: Catalytic and Green Processes, CRC Press. 2.
Author: John Whittall
Publisher: John Wiley & Sons
Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.
2, p 753–768; (f) Sartori, G.; Maggi, R. Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes; CRC Press: Boca Raton, 2010. 4. (a) Pearson, D. E.; Buehler, C. A. Synthesis 1972, 1972, 533–542; (b) Sartori, G.; ...
Author: Brian M. Stoltz
Publisher: John Wiley & Sons
The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products.
74 Sartori, G.and Maggi, R., Advances in Friedel–Crafts Acylation Reactions: Catalytic and Green Processes, CRC Press, Boca Raton, FL, 2009. 75 Taylor, J. E., Jones, M.D., Williams, J.M. T., and Bull,S. P., Org. Lett., 12, 5740 (2010).
Author: A. C. Knipe
Publisher: John Wiley & Sons
Organic Reaction Mechanisms 2010, the 46th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2010. It details the latest progress in a wide range of classes of organic reaction mechanisms, including reactions of different compounds and acids and their derivatives, oxidation and reduction, aliphatic substitutions, elimination reactions, and molecular rearrangements, to name a few. An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
Reaction Mechanisms and Methods for Aromatic Compounds Jacques Mortier ... (b) Sartori, G., Maggi, R. (2009) Advances in Friedel‐Crafts Acylation Reactions Catalytic and Green Processes, CRC Press, Boca Raton, FL.
Author: Jacques Mortier
Publisher: John Wiley & Sons
Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. • Surveys methods used for preparing arene compounds and their transformations • Connects reactivity and methodology with mechanism • Helps readers apply aromatic reactions in a practical context by designing syntheses • Provides essential information about techniques used to determine reaction mechanisms
 V.V. Kouznetsov, Recent synthetic developments in a powerful imino Diels-Alder reaction (Povarov reaction): application ... A review of new developments in the Friedel-Crafts alkylation—from green chemistry to asymmetric catalysis, ...
Author: Sunil S Joshi
Industrial Catalytic Processes for Fine and Specialty Chemicals provides a comprehensive methodology and state-of-the art toolbox for industrial catalysis. The book begins by introducing the reader to the interesting, challenging, and important field of catalysis and catalytic processes. The fundamentals of catalysis and catalytic processes are fully covered before delving into the important industrial applications of catalysis and catalytic processes, with an emphasis on green and sustainable technologies. Several case studies illustrate new and sustainable ways of designing catalysts and catalytic processes. The intended audience of the book includes researchers in academia and industry, as well as chemical engineers, process development chemists, and technologists working in chemical industries and industrial research laboratories. Discusses the fundamentals of catalytic processes, catalyst preparation and characterization, and reaction engineering Outlines the homogeneous catalytic processes as they apply to specialty chemicals Introduces industrial catalysis and catalytic processes for fine chemicals Includes a number of case studies to demonstrate the various processes and methods for designing green catalysts
Chem Rev 107:2546–2562 Tundo P, Anastas P et al (2000) Synthetic pathways and processes in green chemistry. Introductory overview. ... (c) Sartori G, Maggi R (2006) Use of solid catalysts in Friedel-Crafts acylation reactions.
Author: K. L. Ameta
The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.
7.5 Concluding remarks As envisioned in the first edition of this book, photocatalytic Minisci reaction is emerging as a ... testifies the advances that have been done for managing the regio- and stereo-selectivity of the process, ...
Author: Goutam Brahmachari
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability