Bioenergetics of the Cell Quantitative Aspects

Bioenergetics of the Cell  Quantitative Aspects

This volume continues the discussion of the problems of in vivo and in vitro.

Author: Valdur A. Saks

Publisher: Springer Science & Business Media

ISBN: 9781461556534

Category: Science

Page: 460

View: 492

This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.
Categories: Science

Creatine Kinase and Brain Energy Metabolism

Creatine Kinase and Brain Energy Metabolism

Cell . Biochem . 133/134 ( 1994 ) 155–192 . [ 8 ] West I.C. Molecular and physicochemical aspects . ... Ventura - Clapier R. , Leverve X. , Rossi A. , Rigoulet M. ( Eds ) Bioenergetics of the cell : quantitative aspects Kluver Academic ...

Author: Téa Kekelidze

Publisher: IOS Press

ISBN: 158603233X

Category:

Page: 191

View: 844

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Creatine Kinase

Creatine Kinase

( 1995 ) Bioenergetics and muscle cell types . Adv . Exp . Med . ... [ 191 ] Saks V. A. , Ventura - Clapier R , Leverve X. , Rigoulet M. and Rossi A. ( Eds . ) ( 1998 ) Bioenergetics of the cell : quantitative aspects . Mol . Cell .

Author: Christian Vial

Publisher: Nova Publishers

ISBN: 1594547157

Category: Medical

Page: 281

View: 374

Creatine kinases and arginine kinases are an historical model in enzymology. They belong to the large family of phosphagen kinases which transfer a phosphoryl group from ATP to a nitrogen atom within a guanidinium group to form that was called by the early muscle physiologists a 'phosphagen'. These compounds and the enzymes that catalyse their formation and use are present in cells with important and rapidly fluctuating energy requirements.
Categories: Medical

Cardiac Cell Biology

Cardiac Cell Biology

Cellular. Biochemistry. Series Editor: Naranjan S. Dhalla, Ph.D., M.D. (Hon.), FACC 10. 11. 12. 13. 14. 15. 16. 17. 18. ... Biological Effects of Glutamic Acid and Its Derivatives. ... Bioenergetics of the Cell: Quantitative Aspects.

Author: Elissavet Kardami

Publisher: Springer Science & Business Media

ISBN: 9781475747126

Category: Science

Page: 194

View: 343

Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.
Categories: Science

Oxygen Nitrogen Radicals Cell Injury and Disease

Oxygen Nitrogen Radicals  Cell Injury and Disease

Cellular. Biochemistry. Series Editor: Naranjan S. Dhalla, Ph.D., M.D. (Hon.), FACC 10. 11. 12. 13. 14. 15. 16. 17. 18. ... Biological Effects of Glutamic Acid and Its Derivatives. ... Bioenergetics of the Cell: Quantitative Aspects.

Author: Val Vallyathan

Publisher: Springer Science & Business Media

ISBN: 9781461510871

Category: Science

Page: 406

View: 496

A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.
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Mitochondrial Remodeling and Dynamic Inter Organellar Contacts in Cardiovascular Physiopathology

Mitochondrial Remodeling and Dynamic Inter Organellar Contacts in Cardiovascular Physiopathology

Bioenergetics of the Cell: Quantitative Aspects. Dordrecht: Kluwer Academic Press. Saks, V. A., and Ventura-Clapier, R. E. (1994). Cellular Bioenergetics: Role of Coupled Creatine Kinases. Molecular and Cellular Biochemistry.

Author: Giampaolo Morciano

Publisher: Frontiers Media SA

ISBN: 9782889669424

Category: Science

Page:

View: 449

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Natural Biomarkers for Cellular Metabolism

Natural Biomarkers for Cellular Metabolism

In Bioenergetics of the Cell: Quantitative Aspects, V. A. Saks, R. Ventura-Clapier, X. Leverve et al. (eds.). Vol. 25 of Developments in Molecular and Cellular Biochemistry, pp. 81–100. New York: Springer. Scholz, R., R. G. Thurman, ...

Author: Vladimir V. Ghukasyan

Publisher: CRC Press

ISBN: 9781466509993

Category: Medical

Page: 408

View: 219

From the Lab to Clinical Settings—Advances in Quantitative, Noninvasive Optical Diagnostics Noninvasive fluorescence imaging techniques, novel fluorescent labels, and natural biomarkers are revolutionizing our knowledge of cellular processes, signaling and metabolic pathways, the underlying mechanisms for health problems, and the identification of new therapeutic targets for drug discoveries. Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications delves into the current state of knowledge on intrinsic fluorescent biomarkers and highlights recent developments in using these biomarkers for the metabolic mapping and clinical diagnosis of healthy and diseased cells and tissues. Autofluorescent Biomarkers for Biomedical Diagnostics The book’s first section introduces the fundamentals of cellular energy metabolism as well as natural biomarkers within the context of their biological functions. The second section outlines the theoretical and technical background of quantitative, noninvasive, autofluorescence microscopy and spectroscopy methods, including experimental design, calibration, pitfalls, and remedies of data acquisition and analysis. The last two sections highlight advances in biomedical and biochemical applications, such as monitoring stem cell differentiation in engineered tissues and diagnosing cancer and ophthalmic diseases quantitatively and noninvasively. Tailored to Interdisciplinary Researchers Covering cell biology, imaging techniques, and clinical diagnostics, this book provides readers with a complete guide to studying cellular/tissue metabolism under healthy, diseased, and environment-induced stress conditions using natural biomarkers. The book is designed for graduate and advanced undergraduate students, biophysics instructors, medical researchers, and those in pharmaceutical R&D.
Categories: Medical

Cardiomyocytes in Health and Disease

Cardiomyocytes in Health and Disease

Bioenergetics of the Cell: Quantitative Aspects: Springer; 1998. p. 231–47. 119. Saks V, Beraud N, Wallimann T. Metabolic compartmentation–a system level property of muscle cells. Int J Mol Sci. 2008;9(5):751–67. 120.

Author: Chandrasekharan C. Kartha

Publisher: Springer Nature

ISBN: 9783030855369

Category: Science

Page: 345

View: 879

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
Categories: Science

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology

Integration of Molecular and Cellular Processes Abel Lajtha, Gary E. Gibson, Gerry A. Dienel, Gerald A. Dienel ... Is there creatine kinase equilibrium in working heart cells? ... Bioenergetics of the cell: Quantitative aspects.

Author: Abel Lajtha

Publisher: Springer Science & Business Media

ISBN: 9780387303666

Category: Medical

Page: 924

View: 325

Categories: Medical

Cellular Lipid Binding Proteins

Cellular Lipid Binding Proteins

Bioenergetics of the Cell: Quantitative Aspects. 1998 G.N. Pierce, H. Rupp, T. Izumi and A. Grynberg (eds.): Molecular and Cellular Effects of Nutrition on Disease Processes. 1998 K. Ahmed, E. Chambaz and O.G. Issinger (eds.): ...

Author: Jan Jansen

Publisher: Springer Science & Business Media

ISBN: 9781441992703

Category: Science

Page: 237

View: 390

It is well established that cellular lipid binding proteins serve central roles in cellular lipid uptake and metabolism. Evidence has been presented that various metabolic diseases, such as hyperlipidemia, atherosclerosis, insulin resistance, and diabetes, are characterized by malfunctioning or deficiencies in cellular lipid binding proteins. For better understanding of the action of lipids as signaling compounds and the role of lipids in intermediary metabolism, it is essential to have detailed knowledge of the interactions between lipids and their cognant binding proteins. In view of this growing interest in lipid-protein interaction, the 4th International Conference on Lipid Binding Proteins was held in Maastricht, The Netherlands, in June 2001. The proceedings of the previous three meetings have been published in Molecular and Cellular Biochemistry. The present focused issue of Molecular and Cellular Biochemistry comprises selected papers based on the lectures and posters presented during the 4th conference, and provides insight into the significance of these proteins for the functioning of the cell.
Categories: Science