CHAPTER 2 Principles of Coordination Chemistry Related to Bioinorganic Research This chapter presents aspects of inorganic coordination chemistry that are of particular relevance to the roles of metal ions in biology .
Author: Stephen J. Lippard
Publisher: University Science Books
As one of the most dynamic fields in contemporary science, bioinorganic chemistry lies at a natural juncture between chemistry, biology, and medicine. This rapidly expanding field probes fascinating questions about the uses of metal ions in nature. Respiration, metabolism, photosynthesis, gene regulation, and nerve impulse transmission are a few of the many natural processes that require metal ions, and new systems are continually being discovered. The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance. This introductory text, written by two pioneering researchers, is destined to become a landmark in the field of bioinorganic chemistry through its organized unification of key topics. Accessible to undergraduates, the book provides necessary background information on coordination chemistry, biochemistry, and physical methods before delving into topics that are central to the field: What metals are chosen and how are they taken up by cells? How are the concentrations of metals controlled and utilized in cells? How do metals bind to and fold biomolecules? What principles govern electron transfer and substrate binding and activation reactions? How do proteins fine-tune the properties of metals for specific functions? For each topic discussed, fundamentals are identified and then clarified through selected examples. An extraordinarily readable writing style combines with chapter-opening principles, study problems, and beautifully rendered two-color illustrations to make this book an ideal choice for instructors, students, and researchers in the chemical, biological, and medicalcommunities.
Chapter 1 is an overview of biogeochemical aspects of bioinorganic chemistry, and Chapter 2 gives a brief introduction to relevant inorganic chemistry. Chapter 3 is a discussion of the basic issue of why enzymes are so efficient.
Author: Ei-Ichiro Ochiai
Publisher: Academic Press
Written by a preeminent teacher and scientist in the field, this book provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject. • Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information • Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry) • Presents concepts through extensive four-color visuals, appealing to a range of learning styles • Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter
Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological ...
Author: Dieter Rehder
Publisher: OUP Oxford
Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.
A few thematic volumes of Chemical Reviews are also devoted to topics related to this book: – Vol. 96(7) “Bioinorganic Enzymology” (1996) – Vol. 99(9) “Medicinal Inorganic Chemistry” (1999) – Vol. 104(2) “Biomimetic Inorganic Chemistry” ...
Author: Nils Metzler-Nolte
Publisher: Walter de Gruyter
This book presents a unique introduction into the field of bioinorganic chemistry through practical laboratory experiments. Topics include many aspects of modern bioinorganic chemistry such as model systems for metalloenzymes, biosensors, metal bioconjugates and metal-based drugs. Each chapter contains a brief introduction, followed by detailed experimental procedures, completed with all necessary background information for the student as well as their instructors. A valuable supplement to standard textbooks of inorganic and bioinorganic chemistry Essential for all instructors teaching laboratory courses in general and inorganic chemistry
Author: Rosette M. Roat-MalonePublish On: 2007-10-12
3.1 INTRODUCTION 3.1.1 Analytical Instrument-Based Methods Lawrence Que, Jr., has stated in the preface to Physical Methods in Bioinorganic Chemistry: “By piecing together the various clues derived from the physical methods, ...
Author: Rosette M. Roat-Malone
Publisher: John Wiley & Sons
An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. Rather than striving to provide a broad overview of the whole, rapidly expanding field, this resource provides essential background material, followed by detailed information on selected topics. The goal is to give readers the background, tools, and skills to research and study bioinorganic topics of special interest to them. This extensively updated premier reference and text: Presents review chapters on the essentials of inorganic chemistry and biochemistry Includes up-to-date information on instrumental and analytical techniques and computer-aided modeling and visualization programs Familiarizes readers with the primary literature sources and online resources Includes detailed coverage of Group 1 and 2 metal ions, concentrating on biological molecules that feature sodium, potassium, magnesium, and calcium ions Describes proteins and enzymes with iron-containing porphyrin ligand systems-myoglobin, hemoglobin, and the ubiquitous cytochrome metalloenzymes-and the non-heme, iron-containing proteins aconitase and methane monooxygenase Appropriate for one-semester bioinorganic chemistry courses for chemistry, biochemistry, and biology majors, this text is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers who need a general introduction to bioinorganic chemistry, as well as chemists who want an accessible desk reference.
Approaches in Spectroscopy and Chemical Reactions R. C. Maurya , J. M. Mir , 2019 ISBN 978-3-11-063496-9 , e - ISBN 978-3-11-063503-4 NEW - GENERATION BIOINORGANIC COMPLEXES New - Generation Bioinorganic Complexes Renata Jastrzab ...
Author: Ram Charitra Maurya
Publisher: Walter de Gruyter GmbH & Co KG
This book covers different aspects of bioinorganic chemistry with in-depth and up-to-date coverage. Topics include photosynthesis, nitric oxide complexes and their therapeutic aspects in human beings and plants, carbon monoxide complexes and their therapeutic aspects in human beings and plants, and gaseous signaling molecule hydrogen sulfide and their donors in ophthalmic diseases and physiological implications in plants.
... Studies of Siderophores, Transport, Sterochemistry & Thermodynamics Iron transport by siderophores has many practical implications to understanding the basic bioorganic, bioinorganic and coordination chemistry of these compounds.
Author: D.P. Kessissoglou
Publisher: Springer Science & Business Media
Bioinorganic chemistry is primarily concerned with the role of metal atoms in biology and is a very active research field. However, even though such important structures of metalloenzymes are known, as the MoFeCo of nitrogenase, Cu or Mn superoxide dismutase and plastocyanin, the synthetic routes to the modelling of such centers remains a matter of acute scientific interest. Other metalloenzymes, such as the Mn center of the oxygen evolving complex of PSII, are still the focus of in-depth examination, both spectroscopic and structural. Another area of concern is the interaction between drugs and metals and metal ion antagonism. Understanding the chemistry of metal ions in biological systems will bring benefits in terms of understanding such problems as biomineralization and the production of advanced materials by micro-organisms. The 29 contributions to Bioinorganic Chemistry: An Inorganic Perspective of Life give an excellent summary of the state of the art in this field, covering areas from the NMR of paramagnetic molecules to the use of lanthanide porphyrins in artificial batteries.
That being said, the idea of Bob not having some chemistry to write about even in his retirement would have seemed ... His paperback Bioinorganic Chemistry, first published in 1984, was the first book to provide a “get started” approach ...
Author: R.W. Hay
The aim of this series is to provide authoritative reviews in the rapidly expanding area of bioinorganic chemistry. The series will present "state of the art" reviews covering the whole field of bioinorganic chemistry. The present volume is the fourth in the series and covers the topics: lithium in biology, the structure and function of ceroplasmin, rhenium complexes in nuclear medicine, the anti-HIV activity of macrocyclic polyamines and their metal complexes for dinuclear phosphoesterase enzymes.
In the last chapter in this section, Christodoulou describes some very different and novel chemistry, with copper ... out of the Editors' interest in holding an international get-together on the bioinorganic chemistry of copper; ...
Author: K.D. Karlin
Publisher: Springer Science & Business Media
Bioinorganic Chemistry of Copper focuses on the vital role of copper ions in biology, especially as an essential metalloenzyme cofactor. The book is highly interdisciplinary in its approach--the outstanding list of contributors includes coordination chemists, biochemists, biophysicists, and molecular biologists. Chapters are grouped into major areas of research interest in inorganic copper chemistry, spectroscopy, oxygen chemistry, biochemistry, and molecular biology. The book also discusses basic research of great potential importance to pharmaceutical scientists. This book is based on the first Johns Hopkins University Copper Symposium, held in August 1992. Researchers in chemistry, biochemistry, molecular biology, and medicinal chemistry will find it to be an essential reference on its subject.
... Potential Energy Surfaces for Metal-Assisted Chemical Reactions; Quantum Mechanical/Molecular Mechanical (QM/MM) Methods and Applications in Bioinorganic Chemistry; Spin-Orbit Coupling: Effects in Heavy Element Chemistry.
Author: Edward I. Solomon
Publisher: John Wiley & Sons
Over the past several decades there have been major advances in ourability to computationally evaluate the electronic structure ofinorganic molecules, particularly transition metal systems. Thisadvancement is due to the Moore’s Law increase in computingpower as well as the impact of density functional theory (DFT) andits implementation in commercial and freeware programs for quantumchemical calculations. Improved pure and hybrid density functionalsare allowing DFT calculations with accuracy comparable tohigh-level Hartree-Fock treatments, and the results of thesecalculations can now be evaluated by experiment. When calculations are correlated to, and supported by,experimental data they can provide fundamental insight intoelectronic structure and its contributions to physical propertiesand chemical reactivity. This interplay continues to expand andcontributes to both improved value of experimental results andimproved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-artpresentations of quantum mechanical and related methods and theirapplications, written by many of the leaders in the field. Part 1of this volume focuses on methods, their background andimplementation, and their use in describing bonding properties,energies, transition states and spectroscopic features. Part 2focuses on applications in bioinorganic chemistry and Part 3discusses inorganic chemistry, where electronic structurecalculations have already had a major impact. This addition to theEIC Book series is of significant value to both experimentalistsand theoreticians, and we anticipate that it will stimulate bothfurther development of the methodology and its applications in themany interdisciplinary fields that comprise modern inorganic andbioinorganic chemistry. This volume is also available as part of Encyclopedia ofInorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007to 2010, representing areas of key developments in the field ofinorganic chemistry published in the Encyclopedia of InorganicChemistry. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1119994284.html"Findout more/a.
THE ECOLOGICAL IMPORTANCE OF SPECIATION Knowledge of the several chemical forms ( speciation ) that an element can have in ... organisms within 96 h , is important Element Speciation in Bioinorganic Chemistry , edited by Sergio Caroli .
Author: Sergio Caroli
Publisher: John Wiley & Sons
Element speciation determines the different forms a chemicalelement can take within a given compound, enabling chemists topredict possible ramifications for the environment and humanhealth. This comprehensive book focuses on the analytical aspectsand instrumentation of speciation, while covering the gamut ofmetal speciation forms with adverse effects on biological materialsand the environment at large. The book consists of contributions by a truly international groupof leading authorities on element speciation in bioinorganicchemistry. The editor--a contributor here himself--traces thedevelopments in the field, discussing the advances made over thepast decade in various methodologies and the significance of theincreased capacity to detect extremely small concentrations oftrace elements in various media. Several chapters are dedicated to the various methods andapplications of speciation, exploring specific analytical methods,such as direct, chromatographic and nonchromatographic methods, aswell as nuclear-based and voltammetric methods. Others coverspeciation in various natural water and marine environments and itsmanifestation in biological materials, human serum, or foodstuff.In addition, the book examines speciation theory and legal aspectsas well as questions of quality and sources of errors--issues thatunderscore the perennial need to develop new methods for obtainingstill more accurate data. Extremely broad in scope and rich in detail, this volume providesthe key to improving the state of the art in the field, and is sureto stimulate further research. It stands as a one-of-a-kindreference for analytical and inorganic chemists, as well asbiochemists, in a wide range of disciplines, including toxicology,environmental science, nutrition research, clinical chemistry, andpharmacology. A complete reference for the analytical and instrumental aspects ofspeciation This unique volume provides both a comprehensive reference and apractical guide to the complete range of issues arising fromelement speciation. It concentrates on analytical methods andinstrumentation in bioinorganic chemistry--especially as applied towater-related projects--while addressing the larger environmentaland human-health concerns of our times. Complete with over 100 illustrations, this collaborative effort byan international group of experts describes * Methods for the detection and analysis of species elements,including direct methods, atomic spectrometry, nuclear activationanalysis and radio tracer, high-performance chromatography, orvoltammetric procedures * Specific effects of various species elements, including heavymetals, arsenic, and many other trace elements * Biological materials showing concentrations of trace elements,including human serum, milk, and marine organisms * Various environments affected by element speciation, such asnatural waters, sea waters, estuarine, and coastal environments * How to avoid common pitfalls and obtain sound and accuratedata For anyone involved in environmental and earth sciences, as well asthe related areas of public health, pharmacology, toxicology,nutritional research, or environmental regulations, this importantwork offers the most systematic survey of element speciation todate. It also provides historical perspective, a preview ofexpected developments, and a multitude of new ideas for furtherresearch. The author of approximately 240 published papers and three previousbooks, Dr. Caroli is an active member of numerous national andinternational committees and organizations concerned with chemicalsin the environment. He also sits on the editorial or advisoryboards of several scientific journals, including the Journal ofAnalytical Atomic Spectroscopy, Environmental Science and PollutionResearch International, and Microchemical Journal.
1990, 100, 573—610: Bio-inorganic chemistry: its conceptual evolution. 2. R. J. P. Williams, Coord. Chem. Rev. 2001, 216—217, 583—595: Chemical selection of elements by cells. 3. J. Szpunar, Anal. Bioanal. Chem.
Author: Wolfgang Kaim
Publisher: John Wiley & Sons
The field of Bioinorganic Chemistry has grown significantly inrecent years; now one of the major sub-disciplines of InorganicChemistry, it has also pervaded other areas of the life sciencesdue to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistryof Life, Second Edition provides a detailed introduction to therole of inorganic elements in biology, taking a systematicelement-by-element approach to the topic. The second edition ofthis classic text has been fully revised and updated to include newstructure information, emerging developments in the field, and anincreased focus on medical applications of inorganic compounds. Newtopics have been added including materials aspects of bioinorganicchemistry, elemental cycles, bioorganometallic chemistry, medicalimaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium andchromium Function and transport of alkaline and alkaline earth metalcations Biomineralization Biological functions of the non-metallic inorganicelements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging usinginorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review ofbioinorganic chemistry for advanced students of chemistry,biochemistry, biology, medicine and environmental science.
In: Crichton, R.R., Louro, R.O. (Eds.), Practical Approaches to Biological Inorganic Chemistry. Elsevier, Amsterdam, pp. 179À216. L ́eger, C., Bertrand, V., 2008. Direct electrochemistry of redox enzymes as a tool for mechanistic ...
Author: Robert R. Crichton
Publisher: Academic Press
Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Third Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. The fascinating world of the role of metals in biology, medicine and the environment has progressed significantly since the very successful Second Edition of the book published in 2012. Beginning with an overview of metals and selected nonmetals in biology, the book supports the interdisciplinary nature of this vibrant area of research by providing an introduction to basic coordination chemistry for biologists and structural and molecular biology for chemists. Having built this accessible foundation, the book progresses to discuss biological ligands for metal ions, intermediary metabolism and bioenergetics, and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment. Now in its Third Edition, this popular and award-winning resource highlights recent exciting advances and provides a thorough introduction for both researchers approaching the field from a variety of backgrounds, as well as advanced students. Includes a thorough survey of metals in biological systems: in the human body, in medicine and in the environment Previous winner (Second Edition) of the 2013 Textbook Excellence Award (Texty) from the Text and Academic Authors Association Features new sections: an overview of the different functions of essential metal ions; toxic metals in diagnosis and therapeutics; crystal and ligand field theory and their limitations; molecular orbital theory; genetic and molecular biological approaches to study metals; more complex cofactors and their biosynthesis; photosynthetic oxidation of water; man-made environmental pollution; and metals as poisons
Author: Rosette M. Roat-MalonePublish On: 2020-01-31
Introduces students to the basics of bioinorganic chemistry This book provides the fundamentals for inorganic chemistry and biochemistry relevant to understanding bioinorganic topics.
Author: Rosette M. Roat-Malone
Publisher: John Wiley & Sons
Introduces students to the basics of bioinorganic chemistry This book provides the fundamentals for inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. It provides essential background material, followed by detailed information on selected topics, to give readers the background, tools, and skills they need to research and study bioinorganic topics of interest to them. To reflect current practices and needs, instrumental methods and techniques are referred to and mixed in throughout the book. Bioinorganic Chemistry: A Short Course, Third Edition begins with a chapter on Inorganic Chemistry and Biochemistry Essentials. It then continues with chapters on: Computer Hardware, Software, and Computational Chemistry Methods; Important Metal Centers in Proteins; Myoglobins, Hemoglobins, Superoxide Dismutases, Nitrogenases, Hydrogenases, Carbonic Anhydrases, and Nitrogen Cycle Enzymes. The book concludes with chapters on Nanobioinorganic Chemistry and Metals in Medicine. Readers are also offered end-of-section summaries, conclusions, and thought problems. Reduces size of the text from previous edition to match the first, keeping it appropriate for a one-semester course Offers primers and background materials to help students feel comfortable with research-level bioinorganic chemistry Emphasizes select and diverse topics using extensive references from current scientific literature, with more emphasis on molecular biology in the biochemistry section, leading to a discussion of CRISPR technology Adds new chapters on hydrogenases, carbonic anhydrases, and nitrogen cycle enzymes, along with a separate chapter on nanobioinorganic chemistry Features expanded coverage of computer hardware and software, metalloenzymes, and metals in medicines Supplemented with a companion website for students and instructors featuring Powerpoint and JPEG figures and tables, arranged by chapter Appropriate for one-semester bioinorganic chemistry courses, Bioinorganic Chemistry: A Short Course, Third Edition is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers in need of a general introduction to the subject, as well as chemists requiring an accessible reference.
In reality ligand orbitals participate substantially in the valence orbitals forming covalent chemical bonds so that the ... The most prominent examples of large covalence contribution to the efg in bioinorganic chemistry are found for ...
Author: Robert R. Crichton
Practical Approaches to Biological Inorganic Chemistry, Second Edition, reviews the use of spectroscopic and related analytical techniques to investigate the complex structures and mechanisms of biological inorganic systems that contain metals. Each chapter presents an overview of the technique, including relevant theory, a clear explanation of what it is, how it works, and how the technique is actually used to evaluate biological structures. New chapters cover Raman Spectroscopy and Molecular Magnetochemistry, but all chapters have been updated to reflect the latest developments in discussed techniques. Practical examples, problems and many color figures are also included to illustrate key concepts. The book is designed for researchers and students who want to learn both the basics and more advanced aspects of key methods in biological inorganic chemistry. Presents new chapters on Raman Spectroscopy and Molecular Magnetochemistry, as well as updated figures and content throughout Includes color images throughout to enable easier visualization of molecular mechanisms and structures Provides worked examples and problems to help illustrate and test the reader’s understanding of each technique Written by leading experts who use and teach the most important techniques used today to analyze complex biological structures
... the mechanistic tools developed for the analysis of kinetic and extrakinetic data have proved their worth in the classification of a wide range of reaction types in coordination, organometallic and bioinorganic chemistry.
Author: Ivano Bertini
Publisher: EOLSS Publications
Inorganic and Bio-Inorganic Chemistry is the component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Inorganic and Bio-Inorganic Chemistry in the Encyclopedia of Chemical Sciences, Engineering and Technology Resources deals with the discipline which studies the chemistry of the elements of the periodic table. It covers the following topics: From simple to complex compounds; Chemistry of metals; Inorganic synthesis; Radicals reactions with metal complexes in aqueous solutions; Magnetic and optical properties; Inorganometallic chemistry; High temperature materials and solid state chemistry; Inorganic biochemistry; Inorganic reaction mechanisms;Homogeneous and heterogeneous catalysis; Cluster and polynuclear compounds; Structure and bonding in inorganic chemistry; Synthesis and spectroscopy of transition metal complexes; Nanosystems;Computational inorganic chemistry; Energy and inorganic chemistry. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs
Journal of Biological Inorganic Chemistry, 9, 189e196. Hart, P. J. (2006). Pathogenic superoxide dismutase structure, folding, aggregation and turnover. Current Opinion in Chemical Biology, 10, 131e138. Harris, Z. L., Davis-Kaplan, ...
Author: Robert R. Crichton
The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. This revised and expanded text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten, chromium and selected non-metals. The final five chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on. Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject. Many colour illustrations. Enables easier visualization of molecular mechanisms Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters
Introduction Bernhard Lippert Within the field of bioinorganic chemistry , ' metals in medicine ' and ' metal - nucleic acid interactions ' represent well - established disciplines . In fact , medical applications of metals , metal ...
Author: Alfred X. Trautwein
Whenever nature has a difficult task to perform it can be expected that a metal ion or a cluster of such ions is employed. Metal ions are indispensable for the integrity of biological structures and the catalysis of biological reactions. Knowledge about their mode of action, their uptake in the cell, their handling and their storage is important for the development of new pharmaceuticals. This book summarizes latest results of interdisciplinary research on several universities.
115. R. Breslow , in R. F. Gould , ed . , Bioinorganic Chemistry ( Advances in Chemistry Series , vol . 100 ) , American Chemical Society , 1971 ; Chapter 2 . 116. A. Schepartz and R. Breslow , J. Am . Chem . Soc . 109 ( 1987 ) , 1814 .
Author: Ivano Bertini
Publisher: Univ Science Books
Written by major contributors to the field, Bioinorganic Chemistry provides students with an introduction and overview of the subject and gives them the background required to read and follow the current research literature.