Biomarkers for Endometriosis

Biomarkers for Endometriosis

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine.

Author: Thomas D'Hooghe

Publisher: Springer

ISBN: 9783319598567

Category: Health & Fitness

Page: 267

View: 484

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Categories: Health & Fitness

Diagnosis of Endometriosis

Diagnosis of Endometriosis

One of the main problems for the management of endometriosis is the significant diagnostic delay: to date, several biomarkers are currently being tested in order to provide a reliable non-invasive diagnosis in case of symptoms and signs ...

Author: Antonio Simone Laganà

Publisher: Mdpi AG

ISBN: 3036528016

Category:

Page: 130

View: 935

Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a wide range of symptoms and signs, including acute and chronic pelvic pain and infertility. Endometriosis affects approximately 10% of women of reproductive age, and up to 50% of infertile women. The etiopathogenesis of endometriosis still remains controversial: immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it. One of the main problems for the management of endometriosis is the significant diagnostic delay: to date, several biomarkers are currently being tested in order to provide a reliable non-invasive diagnosis in case of symptoms and signs suspicious for endometriosis. In addition, ultrasound techniques and magnetic resonance imaging are evolving rapidly, allowing for better accuracy, even with the use of artificial intelligence. Finally, new potential histological makers are helping to correlate the occurrence of endometriosis in different anatomical landmarks, supporting specific pathways to clarify the etiology of the disease.
Categories:

Endometriosis

Endometriosis

microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res. 2013;19(5):1213–24. Jia SZ, Yang Y, Lang J, Sun P, Leng J. Plasma miR-17-5p, miR-20a and miR-22 are downregulated in women ...

Author: Tasuku Harada

Publisher: Springer

ISBN: 9784431544210

Category: Medical

Page: 477

View: 545

Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.
Categories: Medical

The Handbook of Biomarkers

The Handbook of Biomarkers

A non-invasive test for diagnosis of endometriosis will focus the use of laparoscopy on women who are highly suspected of having endometriosis. Considerable efforts are being made to discover biomarkers of endometriosis for non-invasive ...

Author: Kewal K. Jain

Publisher: Humana Press

ISBN: 9781493974313

Category: Science

Page: 760

View: 362

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.
Categories: Science

Endometriosis

Endometriosis

Peripheral biomarkers of endometriosis: A systematic review. Human Reproduction Update, 16(6), 651–674. Shen, F., Liu, X., Geng, J. G., & Guo, S. W. (2009). Increased immunoreactivity to SLIT/ ROBO1 in ovarian endometriomas: A likely ...

Author: Sajal Gupta

Publisher: Springer

ISBN: 9783319183084

Category: Health & Fitness

Page: 115

View: 783

This SpringerBrief provides an update on endometriosis research -- from the underlying mechanisms, predisposing factors, role of environmental pollutants, treatment options, impact on quality of life, and biomarkers, to emerging treatment modalities in order to help clinicians to pursue a patient-centered approach in managing the disease. This book provides clinicians with a better insight into early diagnosis and management of endometriosis. It explores the possible identification of proteins in different types of endometriosis diseases and at different stages of the progression. This may aid in the discovery of potential biomarkers for non-invasive diagnosis of these diseases. The ability to identify a protein, common between women of different races, ages and in different regions of the world will hopefully contribute to improving women’s health worldwide.
Categories: Health & Fitness

How to Perform Ultrasonography in Endometriosis

How to Perform Ultrasonography in Endometriosis

An analysis of the DNA methylome in endometrium from women with endometriosis and disease-free individuals revealed ... of aberrant epigenetic regulation of the endometrium in endometriosis [40]. other biomarkers were assessed in single ...

Author: Stefano Guerriero

Publisher: Springer

ISBN: 9783319711386

Category: Medical

Page: 195

View: 118

This structured dynamic book outlines, step by step, an evidence-based systematic approach to the sonographic evaluation of the pelvis in women with suspected endometriosis. This “how to” guide is intended for those with basic ultrasonography skills who want to further develop their capabilities in performing the relevant sonographic techniques to identify endometriosis. Detailed schematics, and corresponding high-resolution ultrasound images and intuitive videos support readers in expanding their technical skills and bridging the gaps in their knowledge of endometriosis ultrasound. The International Deep Endometriosis Analysis (IDEA) group consensus statement was the culmination of the work of 29 authors from 5 continents. With the publication of How to Perform Ultrasonography in Endometriosis the authors intend to provide the basis for quality improvement and benchmarking of ultrasound in the world of endometriosis. This book not only offers sonologists, radiologists and sonographers valuable insights into the field of endometriosis ultrasound, but also enables them to develop their practical skills in assessing women with chronic pelvic pain.
Categories: Medical

Endometriosis

Endometriosis

A follow-up study testing the diagnostic performance of endometrial antibodies was undertaken and the results compared to ... Given the great variability in the disease, there will likely not be one single biomarker for endometriosis.

Author: Linda C. Giudice, MD

Publisher: John Wiley & Sons

ISBN: 9781444398496

Category: Medical

Page: 552

View: 619

Written by an internationally well-known editor team, Endometriosis: Science and Practice is a state-of-the-art guide to this surprisingly common disease. While no cause for endometriosis has been determined, information of recent developments are outlined in this text, offering insight to improve management of symptoms medically or surgically. The first of its kind, this major textbook integrates scientific and clinical understanding of this painful disease helping to provide better patient care.
Categories: Medical

Endometriosis

Endometriosis

References [1] Sampson J. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. American Journal of Obstetrics and ... Peripheral biomarkers of endometriosis: A systematic review.

Author: Courtney Marsh

Publisher: BoD – Books on Demand

ISBN: 9781839624643

Category: Medical

Page: 130

View: 114

This book provides a comprehensive look at endometriosis, a disease affecting 10 percent of reproductive women. It explores risk factors for endometriosis including environmental factors that are shedding light on this disease. It also investigates novel methods for diagnosing and treating pain related to endometriosis, which can be debilitating in some women. Conditions associated with endometriosis including adenomyosis, invasion of endometrial glands and stroma into the uterine muscle, and infertility are reviewed in depth. Finally, the book examines treatment options for women with endometriosis ranging from hormonal to surgical. This volume is targeted to practitioners seeing patients with endometriosis to better inform them regarding up-to-date diagnostic and treatment options.
Categories: Medical

Endometriosis

Endometriosis

56. endometriosis. In Harada T, ed. Pathogenesis and Treatment. Berlin, Germany: Springer; 2014. Suryawanshi S, Vlad AM, Lin H-M et al. Plasma MicroRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer.

Author: Seema Chopra

Publisher: CRC Press

ISBN: 9780429829338

Category: Medical

Page: 184

View: 249

Endometriosis is a complex gynecological disorder with multifactorial etiology. An estrogen-dependent condition, it affects 6% to 10% of women in the general population, and in 35% to 50% of these women often experience pain, and sometimes infertility. Exploring this benign but chronic disease, the book covers the different aspects of endometriosis from basic to advanced levels, including diagnoses, management, treatment modalities, complications, and fertility. Features Provides an overview of the guidelines, expert opinions, and ethical dilemmas involved with endometriosis. Covers the various complications that these women can experience Presents informative illustrations that complement the text discussion An overview of surgery, hormone therapy, and other options is provided In-depth coverage of novel treatments, including alternative medicine, diet, nutrition, and lifestyle modifications
Categories: Medical

Manual of Endometriosis

Manual of Endometriosis

This manual is a practical guide to endometriosis, presenting the clinical, preventative and research aspects of the condition.

Author: Kanthi Bansal

Publisher: JP Medical Ltd

ISBN: 9789350904046

Category: Medical

Page: 258

View: 722

Endometriosis is a common condition in which small pieces of the womb lining (the endometrium) are found outside the womb. This could be in the fallopian tubes, ovaries, bladder, bowel, vagina or rectum. Endometriosis affects around 2 million women in the UK alone with most of them diagnosed between the ages of 25 and 40 (NHS Choices). This manual is a practical guide to endometriosis, presenting the clinical, preventative and research aspects of the condition. Beginning with an introduction to the condition, its structure and diagnosis, the following chapters cover the management of different types of endometriosis and its related conditions including infertility. Key points Practical guide to endometriosis presenting clinical, preventative and research aspects Covers management of all types of endometriosis and related conditions Includes numerous full colour clinical photographs, illustrations and tables Each chapter extensively referenced
Categories: Medical