Biomarkers for Endometriosis

Biomarkers for Endometriosis

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine.

Author: Thomas D'Hooghe

Publisher: Springer

ISBN: 3319598546

Category: Health & Fitness

Page: 267

View: 279

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Categories: Health & Fitness

Biomarkers for Endometriosis

Biomarkers for Endometriosis

Lusine Aghajanova, R.O. Burney, N.D. Tran, and Linda C. Giudice Abstract At present, the diagnosis of endometriosis is challenged by the absence of a clinically useful diagnostic biomarker(s). A biomarker is defined as a characteristic ...

Author: Thomas D'Hooghe

Publisher: Springer

ISBN: 9783319598567

Category: Health & Fitness

Page: 267

View: 123

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Categories: Health & Fitness

The Handbook of Biomarkers

The Handbook of Biomarkers

Biomarkers. of. Endometriosis. Endometriosis is a painful, chronic disease that occurs when endometrium (tissue that lines the uterus) is found outside the uterus, usually in the abdomen on the ovaries, fallopian tubes, and ligaments ...

Author: Kewal K. Jain

Publisher: Springer Science & Business Media

ISBN: 9781607616856

Category: Medical

Page: 492

View: 534

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.
Categories: Medical

Endometriosis

Endometriosis

This book provides clinicians with a better insight into early diagnosis and management of endometriosis.

Author: Sajal Gupta

Publisher: Springer

ISBN: 9783319183084

Category: Health & Fitness

Page: 115

View: 268

This SpringerBrief provides an update on endometriosis research -- from the underlying mechanisms, predisposing factors, role of environmental pollutants, treatment options, impact on quality of life, and biomarkers, to emerging treatment modalities in order to help clinicians to pursue a patient-centered approach in managing the disease. This book provides clinicians with a better insight into early diagnosis and management of endometriosis. It explores the possible identification of proteins in different types of endometriosis diseases and at different stages of the progression. This may aid in the discovery of potential biomarkers for non-invasive diagnosis of these diseases. The ability to identify a protein, common between women of different races, ages and in different regions of the world will hopefully contribute to improving women’s health worldwide.
Categories: Health & Fitness

Endometriosis

Endometriosis

This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease. Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer.

Author: Tasuku Harada

Publisher: Springer

ISBN: 9784431544210

Category: Medical

Page: 477

View: 361

Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.
Categories: Medical

Endometriosis

Endometriosis

Exploring this benign but chronic disease, the book covers the different aspects of endometriosis from basic to advanced levels, including diagnoses, management, treatment modalities, complications, and fertility.

Author: Seema Chopra

Publisher: CRC Press

ISBN: 9780429829338

Category: Medical

Page: 184

View: 603

Endometriosis is a complex gynecological disorder with multifactorial etiology. An estrogen-dependent condition, it affects 6% to 10% of women in the general population, and in 35% to 50% of these women often experience pain, and sometimes infertility. Exploring this benign but chronic disease, the book covers the different aspects of endometriosis from basic to advanced levels, including diagnoses, management, treatment modalities, complications, and fertility. Features Provides an overview of the guidelines, expert opinions, and ethical dilemmas involved with endometriosis. Covers the various complications that these women can experience Presents informative illustrations that complement the text discussion An overview of surgery, hormone therapy, and other options is provided In-depth coverage of novel treatments, including alternative medicine, diet, nutrition, and lifestyle modifications
Categories: Medical

Manual of Endometriosis

Manual of Endometriosis

This manual is a practical guide to endometriosis, presenting the clinical, preventative and research aspects of the condition.

Author: Kanthi Bansal

Publisher: JP Medical Ltd

ISBN: 9789350904046

Category: Medical

Page: 220

View: 492

Endometriosis is a common condition in which small pieces of the womb lining (the endometrium) are found outside the womb. This could be in the fallopian tubes, ovaries, bladder, bowel, vagina or rectum. Endometriosis affects around 2 million women in the UK alone with most of them diagnosed between the ages of 25 and 40 (NHS Choices). This manual is a practical guide to endometriosis, presenting the clinical, preventative and research aspects of the condition. Beginning with an introduction to the condition, its structure and diagnosis, the following chapters cover the management of different types of endometriosis and its related conditions including infertility. Key points Practical guide to endometriosis presenting clinical, preventative and research aspects Covers management of all types of endometriosis and related conditions Includes numerous full colour clinical photographs, illustrations and tables Each chapter extensively referenced
Categories: Medical

How to Perform Ultrasonography in Endometriosis

How to Perform Ultrasonography in Endometriosis

An analysis of the DNA methylome in endometrium from women with endometriosis and disease-free individuals revealed ... of aberrant epigenetic regulation of the endometrium in endometriosis [40]. other biomarkers were assessed in single ...

Author: Stefano Guerriero

Publisher: Springer

ISBN: 9783319711386

Category: Medical

Page: 195

View: 270

This structured dynamic book outlines, step by step, an evidence-based systematic approach to the sonographic evaluation of the pelvis in women with suspected endometriosis. This “how to” guide is intended for those with basic ultrasonography skills who want to further develop their capabilities in performing the relevant sonographic techniques to identify endometriosis. Detailed schematics, and corresponding high-resolution ultrasound images and intuitive videos support readers in expanding their technical skills and bridging the gaps in their knowledge of endometriosis ultrasound. The International Deep Endometriosis Analysis (IDEA) group consensus statement was the culmination of the work of 29 authors from 5 continents. With the publication of How to Perform Ultrasonography in Endometriosis the authors intend to provide the basis for quality improvement and benchmarking of ultrasound in the world of endometriosis. This book not only offers sonologists, radiologists and sonographers valuable insights into the field of endometriosis ultrasound, but also enables them to develop their practical skills in assessing women with chronic pelvic pain.
Categories: Medical