Cell Kinetic Modelling and the Chemotherapy of Cancer

Cell Kinetic Modelling and the Chemotherapy of Cancer

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed.

Author: Helmut Knolle

Publisher: Springer

ISBN: 3540501533

Category: Medical

Page: 157

View: 416

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).
Categories: Medical

Cell Kinetic Modelling and the Chemotherapy of Cancer

Cell Kinetic Modelling and the Chemotherapy of Cancer

Putten LM van (1974): Are cell kinetic data relevant for the design of tumor chemotherapy schedules? Cell T is s. Kin. 7,493-504 Rubi now SI (1968) : A maturity – time representation for cell populations. Biophys.

Author: Helmut Knolle

Publisher: Springer Science & Business Media

ISBN: 9783642456510

Category: Medical

Page: 157

View: 712

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).
Categories: Medical

Cancer Chemotherapy Reports

Cancer Chemotherapy Reports

BERTALANFFY , F. D. , and NAGY , K. P. Mitotic activity and renewal rate of the epithelial cells of the human duodenum . Acta Anat 45 : 362–370 , 1961 . 10. LIPKIN , M. , BELL , B. , and SHERLOCK , P. Cell proliferation kinetics in the ...

Author:

Publisher:

ISBN: MINN:31951M01252696K

Category: Antineoplastic agents

Page:

View: 454

Categories: Antineoplastic agents

The Theoretical Foundations of Cancer Chemotherapy Introduced by Computer Models

The Theoretical Foundations of Cancer Chemotherapy Introduced by Computer Models

Describes the principles of cancer chemotherapy quantitatively, using computer modelling. The book includes a computer program on disk to allow the user to model tumour biology and drug effects.

Author: Robert C. Jackson

Publisher:

ISBN: UOM:39015028470212

Category: Cancer

Page: 447

View: 741

Describes the principles of cancer chemotherapy quantitatively, using computer modelling. The book includes a computer program on disk to allow the user to model tumour biology and drug effects. This allows a trial and error approach to understanding the principles of chemotherapy.
Categories: Cancer

Mathematical Models of Cancer and Different Therapies

Mathematical Models of Cancer and Different Therapies

L.G.D. Pillis, A. Radunskaya, A mathematical tumor model with immune resistance and drug therapy: an optimal control approach. Comput. Math. Methods Med. 3(2), 79–100 (2001) 5. H. Knolle, Cell Kinetic Modelling and the Chemotherapy of ...

Author: Regina Padmanabhan

Publisher: Springer Nature

ISBN: 9789811586408

Category: Biomathematics

Page: 256

View: 591

This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.
Categories: Biomathematics

The Chemotherapy Source Book

The Chemotherapy Source Book

Single - agent hormonal therapy for metastatic breast or prostate cancer often produces excellent responses and disease control , sometimes for prolonged periods . COMBINATION CHEMOTHERAPY Cancer Cell Growth Kinetics and Drug Resistance ...

Author: Michael Clinton Perry

Publisher: Lippincott Williams & Wilkins

ISBN: 0781773288

Category: Medical

Page: 779

View: 438

The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.
Categories: Medical

The Mechanics and Biophysics of Hearing

The Mechanics and Biophysics of Hearing

58 : C. A. Macken , A. S. Perelson , Branching Processes Applied to Cell Surface Aggregation Phenomena . ... Pattern Learning in Neural Models . ... 75 : H. Knolle , Cell Kinetic Modelling and the Chemotherapy of Cancer .

Author: Peter Dallos

Publisher:

ISBN: 3540974733

Category: Audition (Physiologie) - Congrès

Page: 418

View: 664

Categories: Audition (Physiologie) - Congrès

Biomathematical Problems in Optimization of Cancer Radiotherapy

Biomathematical Problems in Optimization of Cancer Radiotherapy

Knolle, H. (1988) Cell Kinetic Modelling and the Chemotherapy of Cancer, Lecture Notes in Biomathematics 75, Springer-Verlag, Berlin. 40. Kosevich, A. M. and Kruglikov, I. L. (1986) Mathematical model of interphase cell death, ...

Author: A.Y. Yakovlev

Publisher: CRC Press

ISBN: 9781000142396

Category: Mathematics

Page: 144

View: 172

Biomathematical Problems in Optimization of Cancer Radiotherapy provides insight into the role of cell population heterogeneity in the optimal control of fractionated irradiation of tumors. The book emphasizes the mathematical modeling aspect of the problem and presents the state of the art in the stochastic description of irradiated cell survival. Some of the results are of general theoretical interest and can be applied to other areas of optimal control methodology. Detailed explanations of all mathematical statements are provided throughout the text. The book is excellent for biomathematicians, radiotherapists, oncologists, health physicists, and other researchers and students interested in the topic.
Categories: Mathematics

Recent Trends in Differential Equations

Recent Trends in Differential Equations

M. Gyllenberg and G. F. Webb, A nonlinear structured population model of tumor growth with quiescence, J. Math. ... H. Knolle, Cell Kinetic Modelling and the Chemotherapy of Cancer, Lecture Notes in Biomathematics, Vol.

Author: R P Agarwal

Publisher: World Scientific

ISBN: 9789814505628

Category: Mathematics

Page: 600

View: 316

This series aims at reporting new developments of a high mathematical standard and of current interest. Each volume in the series shall be devoted to mathematical analysis that has been applied, or potentially applicable to the solutions of scientific, engineering, and social problems. The first volume of WSSIAA contains 42 research articles on differential equations by leading mathematicians from all over the world. This volume has been dedicated to V Lakshmikantham on his 65th birthday for his significant contributions in the field of differential equations. Contents:Semilinear and Quasilinear Stochastic Differential Equations in Banach Spaces (N U Ahmed)Asymptotic Behaviour of the Nonoscillating Solutions of First Order Linear Nonautonomous Neutral Equations (D Bainov & V Petrov)Boundary and Angular Layer Behavior in Singularly Perturbed Quasilinear Systems (K W Chang & G X Liu)Singular Perturbation for a System of Differential-Difference Equations (S-N Chow & W Huang)Bounds for Solutions Sets of Multivalued ODES (K Deimling)Comparison of Eigenvalues for a Class of Multipoint Boundary Value Problems (P W Eloe & J Henderson)A Solution to the General Bessel Moment Problem (W D Evans et al.)Boundedness in Linear Functional Differential Equations with Infinite Delay (J Kato)Foundation of Invariant Manifold Theory for Ordinary Differential Equations (H W Knobloch)and other papers Readership: Mathematicians and engineers. keywords:Differential Equations
Categories: Mathematics

Computer Modeling and Simulations of Complex Biological Systems 2nd Edition

Computer Modeling and Simulations of Complex Biological Systems  2nd Edition

Potten , C. S. , Stem Cells , Churchill Livingstone , Edingburgh , 1983 . 27. Düchting , W. and Vogelsaenger , T. , Three ... Knolle , H. , Cell Kinetic Modelling and the Chemotherapy of Cancer , Springer - Verlag , Berlin , 1989 . 35.

Author: S. Sitharama Iyengar

Publisher: CRC Press

ISBN: 0849379628

Category: Medical

Page: 208

View: 738

This unique text explores the use of innovative modeling techniques in effecting a better understanding of complex diseases such as AIDS and cancer. From a way of representing the computational properties of protein-folding problems to computer simulation of bimodal neurons and networks, Computer Modeling and Simulations of Complex Biological Systems examines several modeling methodologies and integrates them across a variety of disciplines. This interdisciplinary approach suggests new ways to solve complex problems pertaining to biological systems. Written in clear and simple terms appropriate for both the novice and the experienced researcher, the book presents a step-by-step approach to the subject and includes numerous examples that explain the concepts presented in the text.
Categories: Medical