Chiral Separations by Chromatography

Chiral Separations by Chromatography

" "This book will be a reliable guide for those just starting out in pharmaceutical and related industries, as well as those with experience in the field."--Jacket.

Author: Satinder Ahuja

Publisher: Amer Chemical Society

ISBN: UOM:39015042594211

Category: Science

Page: 244

View: 358

A large number of examples are given that will assist in the selection of a method, including thin-layer chromatography, capillary electrophoresis and membrane separations." "This book will be a reliable guide for those just starting out in pharmaceutical and related industries, as well as those with experience in the field."--Jacket.
Categories: Science

Chiral Separations By Liquid Chromatography And Related Technologies

Chiral Separations By Liquid Chromatography And Related Technologies

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid ...

Author: Hassan Y. Aboul-Enein

Publisher: CRC Press

ISBN: 9781135530754

Category: Science

Page: 400

View: 462

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography
Categories: Science

Chiral Separations

Chiral Separations

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale.

Author: Gerald Gübitz

Publisher: Springer Science & Business Media

ISBN: 9781592596485

Category: Science

Page: 448

View: 815

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.
Categories: Science

Chiral Separations by Liquid Chromatography

Chiral Separations by Liquid Chromatography

Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques.

Author: Satinder Ahuja

Publisher: Amer Chemical Society

ISBN: UOM:39015024892864

Category: Science

Page: 239

View: 966

A definitive reference for researchers working on problems involving chirality. Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques. Four chapters provide a detailed review of the commonly used columns: brush type, cyclodextrin, polysaccaride carbonate, and protein. Many of the papers focus on HPLC, a technique which is also ideally suited for large scale preparation of optical isomers. In addition, the volume provides significant discussion on the use of chiral discriminators or selectors.
Categories: Science

A Practical Approach to Chiral Separations by Liquid Chromatography

A Practical Approach to Chiral Separations by Liquid Chromatography

A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field.

Author: G. Subramanian

Publisher: Wiley-VCH

ISBN: UOM:39015040130901

Category: Science

Page: 405

View: 506

Both analytical and preparative-scale enantioseparation techniques are covered in a down-to-earth practical way. The most important aspects of design, economics and safety are considered with emphasis on current European and North American legislation. In addition, the theory of chiral separation is covered in sufficient detail to guide the practising chromatographer interested in developing new techniques. A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field.
Categories: Science

Thin Layer Chromatography in Chiral Separations and Analysis

Thin Layer Chromatography in Chiral Separations and Analysis

A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo

Author: Teresa Kowalska

Publisher: CRC Press

ISBN: 9780849343964

Category: Medical

Page: 436

View: 831

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo
Categories: Medical

Chiral Separations

Chiral Separations

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987.

Author: D. Stevenson

Publisher: Springer Science & Business Media

ISBN: 9781461566342

Category: Science

Page: 206

View: 447

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.
Categories: Science

Chiral Chromatography

Chiral Chromatography

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc.

Author: Thomas E. Beesley

Publisher: John Wiley & Sons

ISBN: 0471974277

Category: Science

Page: 522

View: 120

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included: * chiral separations involving both gas and liquid chromatography * descriptions of the apparatus used for both techniques * detailed discussion on the retention mechanism that results in chiral selectivity * the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography * preparative applications for large scale purification of enantiomers * applications of capillary electrophoresis and capillary electrochromatography. In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.
Categories: Science

Chiral Separations By Liquid Chromatography And Related Technologies

Chiral Separations By Liquid Chromatography And Related Technologies

In its systematic description of the types, structures and properties of chiral stationary phases (CSPs) and their preparation, application and future scope, this volume highlights an assortment of liquid chromatographic, including sub- and ...

Author: Hassan Y. Aboul-Enein

Publisher: CRC Press

ISBN: 9780824755768

Category: Science

Page: 400

View: 805

In its systematic description of the types, structures and properties of chiral stationary phases (CSPs) and their preparation, application and future scope, this volume highlights an assortment of liquid chromatographic, including sub- and super-critical fluid chromatograph.
Categories: Science

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development.

Author: Satinder Ahuja

Publisher: John Wiley & Sons

ISBN: 1118097750

Category: Science

Page: 400

View: 338

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.
Categories: Science

Chiral Separation Techniques

Chiral Separation Techniques

This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor.

Author: G. Subramanian

Publisher: Wiley-VCH

ISBN: UOM:39015053518059

Category: Science

Page: 350

View: 155

This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst
Categories: Science

Recent Advances in Chiral Separations

Recent Advances in Chiral Separations

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989.

Author: Derek Stevenson

Publisher: Springer

ISBN: 146848284X

Category: Medical

Page: 242

View: 453

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989. Like the preceding meeting, it was jointly organised by the Chromatographic Society and the Robens Institute of the University of Surrey in response to the continued interest in this area of separation science. Of particular interest to the organisers was the very clear change in the nature of the delegates attending this second symposium as compared with the first. At the previous meeting the majority of the delegates were composed of chromatographers with problems in the area of chiral separations who were keen to learn as much as possible about these techniques from the handful of recognised experts in this area. In this second symposium the divide between expert and novice was much less apparent, with the latter providing many interesting and useful contributions to the scientific programme in termt; of both oral and poster presentations.
Categories: Medical

Recent Advances in Chiral Separations

Recent Advances in Chiral Separations

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989.

Author: D. Stevenson

Publisher: Springer Science & Business Media

ISBN: 9781468482829

Category: Medical

Page: 230

View: 601

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989. Like the preceding meeting, it was jointly organised by the Chromatographic Society and the Robens Institute of the University of Surrey in response to the continued interest in this area of separation science. Of particular interest to the organisers was the very clear change in the nature of the delegates attending this second symposium as compared with the first. At the previous meeting the majority of the delegates were composed of chromatographers with problems in the area of chiral separations who were keen to learn as much as possible about these techniques from the handful of recognised experts in this area. In this second symposium the divide between expert and novice was much less apparent, with the latter providing many interesting and useful contributions to the scientific programme in termt; of both oral and poster presentations.
Categories: Medical

Chiral Separations by Liquid Chromatography

Chiral Separations by Liquid Chromatography

In addition, the volume provides significant discussion on the use of chiral discriminators or selectors."--Publisher description (LoC).

Author:

Publisher:

ISBN: OCLC:641423053

Category: Enantiomers

Page: 239

View: 262

Categories: Enantiomers

Chiral Separations by Capillary Electrophoresis

Chiral Separations by Capillary Electrophoresis

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary ElectrophoresisSince the 1980s, modern analytical tools have enabled capillary electrophoresis to become a ...

Author: Ann Van Eeckhaut

Publisher: CRC Press

ISBN: 1420069349

Category: Science

Page: 543

View: 933

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist’s toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.
Categories: Science

Modified Cyclodextrins for Chiral Separation

Modified Cyclodextrins for Chiral Separation

This is in marked contrast to this volume which focuses on the research endeavors concerning the development of cyclodextrin derivatives specifically as either chiral mobile phases for capillary electrophoresis, or chiral stationary phases ...

Author: Weihua Tang

Publisher: Springer Science & Business Media

ISBN: 9783642376481

Category: Science

Page: 258

View: 437

Modified Cyclodextrins for Chiral Separation offers a review of the latest advances in developing modified cyclodextrins as chiral selectors for various chromatographic and electromigration techniques. Over the years, many descriptions of chiral separation have appeared in academic journals and books, but most of them have been devoted to either the development of analytical methods and protocols or the summary of different chiral selectors, including cyclodextrins for chiral separation applications. This is in marked contrast to this volume which focuses on the research endeavors concerning the development of cyclodextrin derivatives specifically as either chiral mobile phases for capillary electrophoresis, or chiral stationary phases for various chromatographic techniques including gas chromatography, or high-performance liquid chromatography and supercritical fluid chromatography. The ongoing thread in this book is the synthesis of structurally-defined cyclodextrin derivatives and their applications in enantiomer separation by means of different analytical techniques. Modified Cyclodextrins for Chiral Separation is intended for those who are interested in expanding their knowledge of cyclodextrin chemistry and chiral separation, and in what cyclodextrin modification can be made to suit the needs of chiral selectors for different analytical techniques. It primarily focuses on the state-of-the-art cyclodextrin chemistry which is the basis for all chiral selectors used in these chiral separation techniques. Weihua Tang, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China. Siu-Choon Ng, PhD, is a professor at the Division of Chemical and Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. Dongping Sun, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China.
Categories: Science

Liquid Chromatography

Liquid Chromatography

After a short historical overview, the materials and technologies used for analytical and preparative scale separation of enantiomers in high-performance liquid chromatography, nano liquid chromatography, simulated moving-bed chromatography ...

Author: B. Chankvetadze

Publisher: Elsevier Inc. Chapters

ISBN: 9780128071090

Category: Science

Page: 688

View: 642

This chapter summarizes major developments in the field of liquid chromatographic separation of enantiomers. After a short historical overview, the materials and technologies used for analytical and preparative scale separation of enantiomers in high-performance liquid chromatography, nano liquid chromatography, simulated moving-bed chromatography, and supercritical fluid chromatography are briefly discussed. In the final part, some future trends in liquid chromatographic separation of enantiomers are overviewed.
Categories: Science

Chiral Separations

Chiral Separations

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987.

Author: Derek Stevenson

Publisher: Springer

ISBN: 1461566355

Category: Science

Page: 206

View: 306

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.
Categories: Science

Chiral Separations by HPLC

Chiral Separations by HPLC

Author: Ante M. Krstulović

Publisher: Prentice Hall

ISBN: 0470212993

Category: Biomolecules

Page: 548

View: 767

Categories: Biomolecules

Design of Chiral Separations by Liquid Chromatography and Capillary Electrophoresis for Amlodipine and Derivatives

Design of Chiral Separations by Liquid Chromatography and Capillary Electrophoresis for Amlodipine and Derivatives

The design of chiral separations in liquid chromatography (LC) and capillary electrophoresis (CE) involves the selection of chiral selectors and eluent parameters, often on a purely empirical basis.

Author: Tracy Sharon Small

Publisher:

ISBN: OCLC:1179621948

Category:

Page: 224

View: 859

The design of chiral separations in liquid chromatography (LC) and capillary electrophoresis (CE) involves the selection of chiral selectors and eluent parameters, often on a purely empirical basis. It would be desirable if rapid screening methods could be designed to rationalise the choice of these chiral selectors. With reference to the use of cyclodextrin (CD) derivatives as chiral selectors, nuclear magnetic resonance spectroscopy (NMR) can play an important role in screening the extent of interactions with chiral solutes, and in probing the nature of the stereoselective interactions involved. Data from high-field NMR on drugs and their derivatives have been explored for screening a number of potential chiral recognition agents, as an aid to the rational design of chiral separations by LC and CE, based on cyclodextrins (alpha, beta, gamma, hydroxypropyl-beta and hydroxyethyl-beta) bonded to silica (LC) and in free solution (CE). In this investigation high-field FT-NMR is used to examine the interaction mechanism between these cyclodextrins and the calcium channel blocker Amlodipine together with a series of its structural analogues. Enantiomeric interactions between the cyclodextrins and Amlodipine are explored using ROESY (rotating frame nuclear Overhauser effect spectroscopy) in order to determine the inclusion mechanism involved......
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