Click Triazoles

Click Triazoles

Discovered by Sharpless-Fokin and Meldal a decade ago, the copper-catalyzed azide–alkyne cycloaddition that forms 1,4-disubstituted 1,2,3-triazole, also referred to as Click-Triazole, has found a truly widespread application in diverse ...

Author: Janez Košmrlj

Publisher: Springer

ISBN: 9783642294297

Category: Science

Page: 236

View: 260

B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles.
Categories: Science

Advances in Triazole Chemistry

Advances in Triazole Chemistry

Click triazoles and glycopolymers In recent years, the synthesis of multi-functionalized glycopolymers with interesting properties has become an attractive research area. The CuAAC approach has been found to be a very efficient ...

Author: Tahir Farooq

Publisher: Elsevier

ISBN: 9780128171141

Category: Science

Page: 264

View: 559

Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries. Includes coverage of the role triazoles play in DNA synthesis Features comprehensive information on 1,2,3-triazoles and 1,2,4-triazoles and their subclasses, synthesis, and applications Serves as an ideal reference for researchers and chemists interested in using triazole chemistry for functionalization, modification, and development of target products
Categories: Science

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry

Click triazoles as chemosensors: 12THC(28)109. Click triazoles for bioconjugation: 12THC(28)163. Conversion of triazoles into other heterocyclic systems using transitionmetal-catalyzed denitrogenative transannulation: 12AG(E)862.

Author:

Publisher: Academic Press

ISBN: 9780128028742

Category: Science

Page: 386

View: 110

Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Categories: Science

Chemistry of 1 2 3 triazoles

Chemistry of 1 2 3 triazoles

Med Chem Res 19:589–602. doi:10.1007/s00044-009-92157 KošmrljJ (ed) (2012) Click triazoles. Springer, Berlin Heidelberg Kamijo S, Jin T, Huo Z et al (2002) Regiospecific synthesis of 2-allyl-1,2,3-triazoles by palladium-catalyzed 1 ...

Author: Wim Dehaen

Publisher: Springer

ISBN: 9783319079622

Category: Science

Page: 384

View: 367

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Categories: Science

Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance Spectroscopy

[CrossRef] [PubMed] Hua, Y.; Flood, A.H. Click chemistry generates privileged CH hydrogen-bonding triazoles: The latest addition to anion supramolecular chemistry. Chem. Soc. Rev. 2010, 39, 1262–1271. [CrossRef][PubMed] Lau, Y.H.; ...

Author:

Publisher: MDPI

ISBN: 9783038429937

Category: Science

Page: 308

View: 395

Nuclear Magnetic Resonance (NMR) spectroscopy is a nondestructive technique that can be used to characterize a wide variety of systems. Sustained development of both methodology and instrumentation have allowed NMR to evolve as a powerful technology, with applications in pure sciences, medicine, drug development, and important branches of industry. NMR provides precise structural information down to each atom and bond in a molecule, and is the only method for the determination of structures of molecules in a solution. This book compiles a series of articles describing the application of NMR in a variety of interesting scientific challenges. The articles illustrate the versatility and flexibility of NMR.
Categories: Science

Advances in Organometallic Chemistry

Advances in Organometallic Chemistry

Tornøe CW, Christensen C, Meldal M. Peptidotriazoles on solid phase: [1,2,3]triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar ... (a) Straub BF. μ-Acetylide and μ-alkenylidene ligands in “clicktriazoles syntheses.

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Publisher: Academic Press

ISBN: 9780128050750

Category: Science

Page: 298

View: 989

Advances in Organometallic Chemistry contains authoritative review articles of worldwide known researchers on the field of organometallic chemistry, covering topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. The book will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications. Contains contributions from leading authorities in the field of organometallic chemistry Covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more Informs and updates readers on all the latest developments in the field Carefully edited to provide easy-to-read material
Categories: Science

Click Reactions in Organic Synthesis

Click Reactions in Organic Synthesis

Click-supported MCRs are nowadays recognized as a vital tool for the synthesis of rare and multistep products in onepot, ... We developed a two-step synthetic protocol of morpholine-fused [5,1-c]-triazoles from sugar alkynes.

Author: Srinivasan Chandrasekaran

Publisher: John Wiley & Sons

ISBN: 9783527694181

Category: Science

Page: 360

View: 786

This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
Categories: Science

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry

A copper-catalyzed click reaction of organic azides with terminal alkynes 147 followed by direct arylation provided a modular syntheses of highly functionalized 1,2,3-triazoles 148 <08OL3081>. N-Propynoyl (5R)-5phenylmorpholin-2-one ...

Author: Gordon W. Gribble

Publisher: Elsevier

ISBN: 0080965164

Category: Science

Page: 572

View: 814

Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 21 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review "Biocatalytic approaches to chiral heterocycles" and "Ring-expanded (‘fat’) purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics." As with previous volumes in the series, Volume 21 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format. * Covers the heterocyclic literature published in 2008 * Includes specialized reviews * Features contributions from leading researchers in their fields
Categories: Science

Click Chemistry in Glycoscience

Click Chemistry in Glycoscience

The Huisgen 1,3-dipolar cycloaddition of azides and alkynes [7] to afford triazoles is probably the most powerful “click” reaction to connect two distinct fragments or residues of similar or different nature. Indeed, the reaction has ...

Author: Zbigniew J. Witczak

Publisher: John Wiley & Sons

ISBN: 9781118275337

Category: Science

Page: 375

View: 601

The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept's background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students.
Categories: Science

Photochemistry Volume 45

Photochemistry  Volume 45

The Authors demonstrated that the stepwise substitution of pyridine with ''click'' triazoles had a significant effect on both the thermo- and photoreactivity of the complexes. In particular, in complexes featuring neither steric ...

Author: Angelo Albini

Publisher: Royal Society of Chemistry

ISBN: 9781788010061

Category: Reference

Page: 236

View: 383

Drawing on the wealth of photochemical research, this volume combines reviews on the latest advances in the field of photochemistry with specific topical highlights relevant to a wide range of academic and commercial disciplines.
Categories: Reference