Cocktail Therapy

Cocktail Therapy

therapist around. ... Along the way, we discovered that there's a cocktail suited for each and every calamity. ... court or with a good cry, we've concluded that the quickest way to banish the blues is with a delicious drink.

Author: Leanne Shear

Publisher: Simon and Schuster

ISBN: 9781416954781

Category: Cooking

Page: 240

View: 933

Forget crying into your beer. When calamity strikes there's a perfect cocktail to ease your woes. During their bartending years, Leanne Shear and Tracey Toomey were often witness to all kinds of personal crises. And while others may take refuge with their therapist or on the racquetball court, Leanne and Tracey concluded that the quickest way to beat the blues is with a delicious drink (or two). That hot guy from last week still hasn't called? Try a Pomegranate Martini -- bold, tasty, but not so lethal that you'll be tempted to drunk dial him. Gain a few pounds? Indulge in a (nearly) guiltless Sugar-Free Mojito. Credit card bill contains a few nasty surprises? A decadent Bourbon Bee Sting will leave you feeling like a million dollars. As dependable as a good friend and guaranteed not to utter a single "I told you so," Cocktail Therapy proves that when life hands you lemons, the best thing to do is make a rum-soaked Tropical Lemonade.
Categories: Cooking

Attacking AIDS with a Cocktail Therapy Drug Combo Sends Deaths Plummeting

Attacking AIDS with a  Cocktail  Therapy  Drug Combo Sends Deaths Plummeting

Triple combination therapy can be used for all HIV - infected infants , children and adolescents treated with HIV drugs . Infants during the first six weeks of life who have been exposed to HIV but whose HIV status is unknown can be ...

Author:

Publisher: DIANE Publishing

ISBN: 1422326799

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Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance

Importantly, side effects caused by combination therapy were comparable to those triggered by IFN-α, while lamivudine monotherapy resulted in minimal adverse effects (Schalm et al., 2000). Combinatorial use of IFN-α and lamivudine has ...

Author: Mohmmad Younus Wani

Publisher: Academic Press

ISBN: 9780128205785

Category: Business & Economics

Page: 268

View: 858

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria
Categories: Business & Economics

Hurdles for Phage Therapy PT to Become a Reality

Hurdles for Phage Therapy  PT  to Become a Reality

Cocktails—the Power of Many In practice, phage therapy is typically applied in two forms. “Monophage therapy” consisting of a single phage, usually with a broad host range for application against a single species, or a phage cocktail ...

Author: Harald Brüssow

Publisher: MDPI

ISBN: 9783039213917

Category: Science

Page: 484

View: 209

Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.
Categories: Science

Phage Therapy A Practical Approach

Phage Therapy  A Practical Approach

The phage cocktail treatment at a MOI of 10 was able to reduce bacterial viable cells by 2-log when compared with the baseline, and 1-log regarding the controls. The infiuence of immune system in in vivo experiments was demonstrated.

Author: Andrzej Górski

Publisher: Springer Nature

ISBN: 9783030267360

Category: Medical

Page: 385

View: 279

This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.
Categories: Medical

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Due to the physiological complexity of tumors a single drug or even a standalone therapy strategy may not be sufficient for effective treatment [151, 152]. Combination chemotherapy, the simultaneous administration of two or multiple ...

Author: Loutfy H. Madkour

Publisher: Academic Press

ISBN: 9780128197783

Category: Business & Economics

Page: 650

View: 813

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy
Categories: Business & Economics

Enterobacteriaceae Antimicrobial Agents and Resistance Relationship with the Therapeutic Approach

Enterobacteriaceae Antimicrobial Agents and Resistance  Relationship with the Therapeutic Approach

Then, phage therapy continued for another 10 days without antibiotic treatment (Figure 2A). ... Following screening, an adapted phage cocktail containing ФJD905, ФJD907, and ФJD908 for the third therapy via bladder irrigation were ...

Author: Maria Teresa Mascellino

Publisher: Frontiers Media SA

ISBN: 9782889715732

Category: Science

Page:

View: 326

Categories: Science

Advances in Phage Therapy Present Challenges and Future Perspectives

Advances in Phage Therapy  Present Challenges and Future Perspectives

This feature may confer advantage for their therapeutic use as a cocktail, but further work is required to determine this within the genomes of our phage mix. Optimizing our cocktail with diverse phage morphologies concurred with other ...

Author: Andrzej Gorski

Publisher: Frontiers Media SA

ISBN: 9782889711260

Category: Science

Page:

View: 361

This Research Topic is dedicated to Prof. Elisabeth Kutter on the occasion of her 80th birthday. Dr. Kutter’s career as a phage scientist has extended nearly 60 years. She has been a pioneer as a woman in science. She started to work with phage at the University of Rochester, New York working with Dr. Wiberg on radioisotopes making excellent progress in the field – progress which was even cited in Luria’s 1969 Nobel Prize talk. Betty first encountered phage therapy during a visit to Georgia in 1990 which was part of a longer stay in the former Soviet Union under a US-USSR research exchange program. Dr. Kutter was one of the first Americans to advocate for phage therapy in the post antibiotic era. Betty started hosting the Evergreen International Phage meetings in Olympia, Washington, from 1975 onward, which helped to develop a strong phage community with participation increasing over the years to 350 at the 23 rd biannual last year. Betty continues to be an active member in the phage community, sharing her experience and working with all of us toward her ultimate goal of making phage therapy available worldwide thus reducing the burden caused by antibiotic resistant bacterial infections.
Categories: Science

Phage Therapy Past Present and Future

Phage Therapy  Past  Present and Future

All components of a phage or phage product cocktail must have been shown to be acceptable as stated above for single phages. In addition, the dynamics between the individual components of the cocktail should also be assessed prior to ...

Author: Stephen T. Abedon

Publisher: Frontiers Media SA

ISBN: 9782889452514

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Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.
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Bacteriophages Isolation From The Environment And Their Antimicrobial Therapeutic Potential

Bacteriophages Isolation From The Environment And Their Antimicrobial Therapeutic Potential

FIGURE 7 | Comparison of the survival rates of the shrimp in different treatment groups in situ. (A) Survival rates of the shrimp ... G-4: Group IV received treatment of the phage cocktail at the final concentration of 2 × 107 PFU/ml.

Author: Krishna Khairnar

Publisher: Frontiers Media SA

ISBN: 9782889667079

Category: Science

Page:

View: 218

Categories: Science