Author: Mark J Mannis, MD, FACSPublish On: 2021-02
Mark J. Mannis, Edward J. Holland, and a team of more than 200 global experts keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management, making this two-volume text ...
Author: Mark J Mannis, MD, FACS
The only reference available that synthesizes this vast subspecialty into a single trustworthy resource, Cornea, 5th Edition, provides state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease. Drs. Mark J. Mannis, Edward J. Holland, and a team of more than 200 global experts keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management, making this two-volume text a must-have resource for residents and fellows, general ophthalmologists, and seasoned cornea specialists. Features more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs that offer superb visual guidance. Contains 14 new chapters, including Nanothin DSAEK, Aqueous Deficiency Dry Eye Syndrome, Evaluation of Recurrent Corneal Erosions, Evaluation of the Corneal Ulcer, Contemporary Approaches to the Biosynthetic Cornea, and Topography Guided Photorefractive Keratectomy, and more. Includes more than 80 video clips of current corneal surgery techniques, including new clips of the application of amniotic membrane penetrating keratoplasty, Descemet rupture management in DALK, and endothelial keratoplasty among others. Covers the latest developments in ocular surface transplantation, including new chapters on Conjunctival Limbal Autograft (CLAU); Living Related Conjunctival Limbal Allograft (Lr-CLAL); Keratolimbal Allograft; Cultivated Limbal Epithelial Transplantation; Simple Limbal Epithelial Transplantation; and Outcomes of Ocular Surface Transplantation. Provides key point overviews in each chapter that offer easier access to crucial information. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author: Robert M. Kliegman, MDPublish On: 2015-04-22
MEGALOCORNEA This is a nonprogressive symmetric condition characterized
by an enlarged cornea (>12 mm in diameter) and an anterior segment in which
there is no evidence of previous or concurrent ocular hypertension. High myopia
Author: Robert M. Kliegman, MD
Publisher: Elsevier Health Sciences
After more than 75 years, Nelson Textbook of Pediatrics remains your indispensable source for definitive, state-of-the-art answers on every aspect of pediatric care. Embracing the new advances in science as well as the time-honored art of pediatric practice, this classic reference provides the essential information that practitioners and other care providers involved in pediatric health care throughout the world need to understand to effectively address the enormous range of biologic, psychologic, and social problems that our children and youth may face. Brand-new chapters and comprehensive revisions throughout ensure that you have the most recent information on diagnosis and treatment of pediatric diseases based on the latest recommendations and methodologies. "The coverage of such a wide range of subjects relating to child health makes this textbook still the gold standard and companion for all pediatricians across the world." Reviewed by Neel Kamal, Sept 2015 "All in all, this is an excellent and detailed paediatric review textbook which represents excellent value for money..truly a textbook for the global community" Reviewed by glycosmedia.com, Sept 2015 Form a definitive diagnosis and create the best treatment plans possible using evidence-based medicine and astute clinical experiences from leading international authors-many new to this edition. A NEW two-volume layout provides superior portability and exceptional ease of use. Gain a more complete perspective. Along with a broader emphasis on imaging and molecular diagnoses and updated references, the new edition includes an increased focus on international issues to ensure relevance in pediatrics practice throughout the world. Effectively apply the latest techniques and approaches with complete updates throughout 35 new chapters, including: Innovations in Addressing Child Health and Survival in Low Income Settings; Developmental Domains and Theories of Cognition; The Reggio Emilia Educational Approach Catatonia ; Refeeding Syndrome; Altitude-associated Illness; Genetic Approaches to Rare and Undiagnosed Diseases; Healthcare?Associated Infections; Intrapartum and Peripartum Infections; Bath salts and other drugs of abuse; Small Fiber Polyneuropathy; Microbiome; Kingella kingae; Mitochondrial Neurogastrointestinal Encephalomyopathy; Nonalcoholic Fatty Liver Disease; Plagiocephaly; CNS Vasculitis; Anterior Cruciate Ligament Rupture; and Sports-Related Traumatic Brain Injury. Recognize, diagnose, and manage genetic and acquired conditions more effectively. A new Rehabilitation section with 10 new chapters, including: Evaluation of the Child for Rehabilitative Services; Severe Traumatic Brain Injury; Spinal Cord Injury and Autonomic Crisis Management; Spasticity; Birth Brachial Plexus Palsy; Traumatic and Sports-Related Injuries; Meningomyelocele; Health and Wellness for Children with Disabilities. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Adipose-derived stem cells are a source for cell therapy of the corneal stroma.
Stem Cells 2008;26(2):570–579. Liu, H., Zhang, J., Liu, C.Y., et al. Cell therapy of
congenital corneal diseases with umbilical mesenchymal stem cells: lumican null
Author: Kerry Atkinson
Publisher: John Wiley & Sons
The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
This updated edition includes 20 brand-new chapters, while an enhanced focus on images provides key visual guidance in this challenging field.
Author: Mark J Mannis
Publisher: Elsevier Health Sciences
Highly praised in its first three editions, Cornea has become a market-leading cornerstone text and the immediate go-to resource for anyone working in this hugely popular and evolving sub-specialty. Offered over two volumes and featuring the knowledge of over 200 experts worldwide, it presents state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic technology, and medical management of corneal and external disease as well as ocular surface disease. This updated edition includes 20 brand-new chapters, while an enhanced focus on images provides key visual guidance in this challenging field. Exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs offer superb visual guidance. 20 brand-new chapters cover the latest advances in the field, such as DMEK, Ultra-Thin DSEK and DSAEK techniques; endothelial cell transplantation; keratoplasty and prosthokeratoplasty techniques; collagen cross-linking; and new refractive surgical techniques (presbyopic implants and SMILE surgery). Boasts over 170 chapters with unique, cutting-edge content, as well as 2,300 clear illustrations – 670 of which are new to this edition. Presents a detailed exposition of the growing number of techniques for lamellar keratoplasty, including outcomes. Includes new sections on the latest developments in the management of ocular surface disease. Key point overviews in each chapter offer easier access to crucial information.
Rosen's Emergency Medicine - Concepts and Clinical Practice, 2-Volume Set
James Adams John A. Marx, Robert S. Hockberger, Ron M. Walls. Figure 69-4.
Severe alkali burn. Note scleral whitening and the cloudy cornea. Severity can be
Author: James Adams
Publisher: Elsevier Health Sciences
Category: Health & Fitness
This reference places the latest information at users' fingertips, and a more streamlined format makes it easy to find the exact information quickly and conveniently. Includes access to a companion Web site for additional resources.
Author: N. Franklin Adkinson, Jr.Publish On: 2013-11-01
Eventually, these changes lead to a malposition of the eyelid margin and
eyelashes become inturned and directed toward the conjunctival and corneal
surfaces. This contact, along with the contact of the keratinized eyelid margin,
leads to a ...
Author: N. Franklin Adkinson, Jr.
Publisher: Elsevier Health Sciences
Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that's suited for clinicians and researchers alike, Middleton's is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients! Stay on top of continuous new developments in clinical allergy and immunology through online access to the Expert Consult site, which will feature regular updates as well as the fully searchable contents.Find all of the information you need quickly and easily with a glossary of allergy and immunology terms; highlighted key points for each chapter; hundreds of crystal-clear images with a full-color format, and access to relevant websites. Apply the latest scientific knowledge and clinical applications with new chapters on Innate and Adaptive Immunity, Immune Tolerance, Immunobiology of IgE and Its Receptors, Resolution of Allergic Inflammation, and Particulate and Allergen Interactions, plus sweeping updates throughout.Take full advantage of the major advances in asthma pathogenesis and management with significant updates on diagnosis, treatment, and special aspects of asthma.Obtain the best results from the newest therapeutics for allergic and immunologic diseases through an expanded discussion of immunotherapy that includes new chapters on Sublingual Immunotherapy, Biologics and Immunosuppressives in Asthma, and Alternative and Complementary Therapies.
Tumors of the conjunctiva and cornea. Surv Ophthalmol. 2004;49:3–24. 5.
Shields CL, Demirci H, Karatza E, et al. Clinical survey of 1643 melanocytic and
nonmelanocytic conjunctival tumors. Ophthalmology. 2004;111:1747–1754. 6.
Author: J. Eduardo Calonje
Publisher: Elsevier Health Sciences
Comprehensive and lavishly illustrated, McKee’s Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You’ll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis – making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies. Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations – the only available reference with this unique combination of features. Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference. Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine. Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics. Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry. Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma. Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors.
Highly praised in its first three editions, "Cornea" has become a market-leading cornerstone text and the immediate go-to resource for anyone working in this hugely popular and evolving sub-specialty. Offered over two volumes and featuring the knowledge of over 200 experts worldwide, it presents state-of-the-art coverage of the expanding range of contemporary corneal surgery, new diagnostic technology, and medical management of corneal and external disease as well as ocular surface disease. This updated edition includes 20 brand-new chapters and 60 video clips, while an enhanced focus on images provides key visual guidance in this challenging field.
Deposition in the cornea produces a benign condition with the appearance of
Kayser–Fleischer rings. If untreated, death ensues from end stage liver disease.
Probably the most significant contribution to cell damage is the generation of
Author: Peter J. O'Brien
Publisher: John Wiley & Sons
Designed as a first-stop reference for researchers and professionals in toxicology, pharmacology and medicine, this handbook is the very first to tie together the knowledge from many disciplines that has so far been available only from widely dispersed sources in the primary literature. As such, it presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures. Clearly divided into four parts, the first systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species. The second discusses the role of genetically determined metabolic malfunctions, such as galactosemia, hyperlipidemia, porphyria, hemochromatosis and related conditions, while part three looks at acquired and chronic diseases caused or exacerbated by endogenous toxins, such as hepatic injury, asthma, rheumatism, colorectal cancer, reperfusion diseases, neurodegneration and aging. The final part reviews currents strategies to control and minimize the effect of endogenous toxins, either by nutritional or pharmacological interventions. With its complete coverage integrating molecular and systemic aspects from the biochemical basis to human disease conditions, this comprehensive reference will appeal to a broad target group of toxicologists, biochemists, nutrition specialists and physicians.
In the spectral range of about 370–1,000 nm, radiation readily penetrates the cornea and the lens reaching the choroid and ... To achieve maximal safety for
the eyes, it is important to adjust the optical filters of the safety goggles to the
Author: Lowell Goldsmith
Publisher: McGraw Hill Professional
The landmark dermatology text that bridges the gap between science and clinical medicine—updated for today’s practice Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick’s as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology—and their practical relevance to general internal medicine—while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. FEATURES More than 3000 full-color photographs DVD with image bank includes downloadable figures from the text New illustration style makes difficult concepts easier to understand Therapeutic ladders with first, second, and third line therapies New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation Expanded medical and surgical therapeutics sections guide you through all treatment options
Lymphedema is a chronic, incurable condition that is characterized by an
abnormal collection of fluid owing to an ... of the central nervous system and cornea.3 Unlike blood capillaries that consist of continuous tubules of endothelial
Author: Terri M. Skirven
Publisher: Elsevier Health Sciences
With the combined expertise of leading hand surgeons and therapists, Rehabilitation of the Hand and Upper Extremity, 6th Edition, by Drs. Skirven, Osterman, Fedorczyk and Amadio, helps you apply the best practices in the rehabilitation of hand, wrist, elbow, arm and shoulder problems, so you can help your patients achieve the highest level of function possible. This popular, unparalleled text has been updated with 30 new chapters that include the latest information on arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management. An expanded editorial team and an even more geographically diverse set of contributors provide you with a fresh, authoritative, and truly global perspective while new full-color images and photos provide unmatched visual guidance. Access the complete contents online at www.expertconsult.com along with streaming video of surgical and rehabilitation techniques, links to Pub Med, and more. Provide the best patient care and optimal outcomes with trusted guidance from this multidisciplinary, comprehensive resource covering the entire upper extremity, now with increased coverage of wrist and elbow problems. Apply the latest treatments, rehabilitation protocols, and expertise of leading surgeons and therapists to help your patients regain maximum movement after traumatic injuries or to improve limited functionality caused by chronic or acquired conditions. Effectively implement the newest techniques detailed in new and updated chapters on a variety of sports-specific and other acquired injuries, and chronic disorders. Keep up with the latest advances in arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management See conditions and treatments as they appear in practice thanks to detailed, full-color design, illustrations, and photographs. Access the full contents online with streaming video of surgical and rehabilitation techniques, downloadable patient handouts, links to Pub Med, and regular updates at www.expertconsult.com. Get a fresh perspective from seven new section editors, as well as an even more geographically diverse set of contributors.
Chapter 21.1 LASERS IN CORNEA 21.1.1 Laser Assisted In Situ Keratomileusis (
LASIK ) R Revathi , M Vanathi ... thus born.1,2 first proposed that the refractive
power of the eye could be altered by subtraction or addition of corneal tissue .
Author: Zia Chaudhuri
Publisher: Wife Goes On
This well-illustrated two volume set covers the field of ophthalmology, from the fundamentals to the most recent advances. Each section is dedicated to a specific area of the eye and covers basic techniques, investigative modules and treatment methods. With the help of 2500 images and illustrations, this book covers topics such as glaucoma, ocular oncology, nystagmus, refractive surgery, strabismus and lasers in ophthalmology. Low vision, medico-legal aspects, operating room sterilisation and ocular emergencies are also discussed.
The gold-standard text in dermatology – completely updated for today’s practice by an all-new editorial board Encyclopedic in scope, yet skillfully edited to make it easy to read and understand, this trusted classic delivers everything clinicians need to know about skin, skin symptoms, and skin diseases. Presented in full color, Fitzpatrick’s covers all the essentials, from the basic science of skin to the day-to-day clinical issues of managing common skin disorders such as acne, skin cancer, and psoriasis. Backed by the expertise of more than 500 world-renowned contributors, and the reference of choice for clinicians, students, and educators, Fitzpatrick’s is enhanced by thousands of full-color photographs and a wealth of newly enhanced tables and diagrams. The Ninth Edition is bolstered by a new global editorial team; a reorganized table of contents; a more simple, readable, and direct writing style, the incorporation of more genetic, syndromic, and treatment information into each chapter; the addition of first, second, and third line treatment options; and improved table presentation. The reorganized table of contents reflects how disease presents rather than its cause.
6.4 DC / APC in the Cornea MHC Class II + DC are resident in the area between
the vascularized conjunctiva and avascular cornea called the limbus . Cells are
recruited into the cornea from this population during inflammatory or pathological
Author: Manfred B. Lutz
Dendritic cells play a key role in human immunoregulation. They are the most potent form of antigen presenting cells, often referred to as "pacemakers of the immune system". The properties of dendritic cells pave the way for multifaceted clinical applications: they can be used to step up immune response to tumor and infectious disease antigens and they are a valuable tool in transplantation medicine. Information available on these important cells continues to escalate, making it almost impossible for anyone working in the field to keep up with developments. This is the most comprehensive handbook on dendritic cells, opening with an introduction by Ralph M. Steinman and written by international experts. It covers all aspects from molecular cell biology to clinical applications and highlights the role of dendritic cells in fighting cancer, virus infections, and autoimmune diseases.
Kfll'alocyde: (Quiescent corneal Mmpha'ga Necivascul anzalion fibroblasts) Fig. 5
. Effects of adenoviral gene transfer of Smad7 on the healing process of an alkali-
burn mouse cornea. (A) At d 20 postalkali burn the control. nonfunctioning.
Author: Sonia B. Jakowlew
Publisher: Springer Science & Business Media
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.
1. Nictitatio irritativa. Winking of the eyes is performed every minute without our
attention, for the purpose of cleaning and moistening the eye-ball; as further
spoken of in Class II. 1. 1.8. When the cornea becomes too dry, it becomes at the
For example, angiogenic factors can stimulate 2 millimeters of capillary outgrowth
in normally avascular tissues (e.g., cornea) under conditions in which cell
proliferation is inhibited; this occurs exclusively through endothelial cell
Author: David Shepro
The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references
Many new developments have taken place in ophthalmology since the publication of the last edition. It therefore became mandatory to revise and update the present edition. To accomplish this many new chapters have been added and the existing ones revised. Thoroughly revised and updated chapters Recent Advances in Lamellar Keratoplasty Principles of Molecular Genetics Intraocular Tumours Recent Advances in Oculoplastic Surgery Ophthalmic Electrodiagnostic Techniques Ultrasonography in Ophthalmology Ocular Coherence Tomography Anterior Segment Trauma Corneal Topography and Wavefront Sensing