In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials.
Author: Alita A. Miller
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and micr.
Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here.
Author: Iqbal Ahmad
Publisher: John Wiley & Sons
Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.
This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development.
Author: Olga Genilloud
Publisher: Royal Society of Chemistry
This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.
This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design.
Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.
Nat Rev Drug Disc 18:169–170 Silver LL (2011) Challenges of antibacterial discovery. Clin Microbiol Rev 24 (1):71–109 Silver LL (2012) Polypharmacology as an emerging trend in antibacterial discovery.
Author: John Bremner
Publisher: Springer Nature
Category: Technology & Engineering
This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
Trends Pharmacol. Sci., 29 (3), 143—150. 10. Hu, Y., Shamaei-Tousi, A., Liu, Y., and Coates, A. (2010) A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal ...
Author: Claudio O. Gualerzi
Publisher: John Wiley & Sons
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Mining bacterial cell division for new antibacterial drugs, p 35–75. In Miller AA, Miller PF (ed), Emerging Trends in Antibacterial Discovery: Answering the Call to Arms. Caister Academic Press, Wymondham, United Kingdom.
Author: Christopher Walsh
Publisher: John Wiley & Sons
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species.
Author: Sadhana Sagar
Publisher: Springer Nature
This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.
cytoplasm at relevant concentration in order to exert their antibacterial activity, and hurdles to overcome are ... 6 Silver, L.L. (2012) Polypharmacology as an emerging trend in antibacterial discovery, in Polypharmacology in Drug ...
Author: Norbert Handler
Publisher: John Wiley & Sons
The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.