Emerging Trends in Antibacterial Discovery

Emerging Trends in Antibacterial Discovery

"A major reference volume on antibacterial discovery from basic science to its impact on public health, this book is essential reading for everyone working in antibacterial research" -- Back cover.

Author: Alita A. Miller

Publisher: Horizon Scientific Press

ISBN: 1904455891

Category: Science

Page: 460

View: 825

"A major reference volume on antibacterial discovery from basic science to its impact on public health, this book is essential reading for everyone working in antibacterial research" -- Back cover.
Categories: Science

Emerging Trends in Antibacterial Discovery

Emerging Trends in Antibacterial Discovery

In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials.

Author: Alita A. Miller

Publisher:

ISBN: 1912530589

Category:

Page: 470

View: 167

In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and micr.
Categories:

New Strategies Combating Bacterial Infection

New Strategies Combating Bacterial Infection

Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here.

Author: Iqbal Ahmad

Publisher: John Wiley & Sons

ISBN: 9783527622948

Category: Science

Page: 322

View: 667

Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.
Categories: Science

Drug Discovery from Natural Products

Drug Discovery from Natural Products

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development.

Author: Olga Genilloud

Publisher: Royal Society of Chemistry

ISBN: 9781849734950

Category: Science

Page: 432

View: 203

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.
Categories: Science

Multiple Action Based Design Approaches to Antibacterials

Multiple Action Based Design Approaches to Antibacterials

Nat Rev Drug Disc 18:169–170 Silver LL (2011) Challenges of antibacterial discovery. Clin Microbiol Rev 24 (1):71–109 Silver LL (2012) Polypharmacology as an emerging trend in antibacterial discovery.

Author: John Bremner

Publisher: Springer Nature

ISBN: 9789811609992

Category: Technology & Engineering

Page: 193

View: 104

This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
Categories: Technology & Engineering

Antibiotics

Antibiotics

Mining bacterial cell division for new antibacterial drugs, p 35–75. In Miller AA, Miller PF (ed), Emerging Trends in Antibacterial Discovery: Answering the Call to Arms. Caister Academic Press, Wymondham, United Kingdom.

Author: Christopher Walsh

Publisher: John Wiley & Sons

ISBN: 9781555819316

Category: Medical

Page: 477

View: 177

A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Categories: Medical

Antibiotics

Antibiotics

Trends Pharmacol. Sci., 29 (3), 143—150. 10. Hu, Y., Shamaei-Tousi, A., Liu, Y., and Coates, A. (2010) A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal ...

Author: Claudio O. Gualerzi

Publisher: John Wiley & Sons

ISBN: 9783527659708

Category: Medical

Page: 576

View: 115

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Categories: Medical

Springer Handbook of Marine Biotechnology

Springer Handbook of Marine Biotechnology

27(1), 45–52 (2008) 27.3 R.J. Quinn, J.E. Janso: Recent developments in natural products: Potential impact on antibacterial drug discovery. In: Emerging Trends in Antibacterial Discovery: Answering the Call to Arms, ed. by A.A. Miller, ...

Author: Se-Kwon Kim

Publisher: Springer

ISBN: 9783642539718

Category: Science

Page: 1512

View: 224

This Springer Handbook provides, for the first time, a complete and consistent overview over the methods, applications, and products in the field of marine biotechnology. A large portion of the surface of the earth (ca. 70%) is covered by the oceans. More than 80% of the living organisms on the earth are found in aquatic ecosystems. The aquatic systems thus constitute a rich reservoir for various chemical materials and (bio-)chemical processes. Edited by a renowned expert with a longstanding experience, and including over 60 contributions from leading international scientists, the Springer Handbook of Marine Biotechnology is a major authoritative desk reference for everyone interested or working in the field of marine biotechnology and bioprocessing - from undergraduate and graduate students, over scientists and teachers, to professionals. Marine biotechnology is concerned with the study of biochemical materials and processes from marine sources, that play a vital role in the isolation of novel drugs, and to bring them to industrial and pharmaceutical development. Today, a multitude of bioprocess techniques is employed to isolate and produce marine natural compounds, novel biomaterials, or proteins and enzymes from marine organisms, and to bring them to applications as pharmaceuticals, cosmeceuticals or nutraceuticals, or for the production of bioenergy from marine sources. All these topics are addressed by the Springer Handbook of Marine Biotechnology. The book is divided into ten parts. Each part is consistently organized, so that the handbook provides a sound introduction to marine biotechnology - from historical backgrounds and the fundamentals, over the description of the methods and technology, to their applications - but it can also be used as a reference work. Key topics include: - Marine flora and fauna - Tools and methods in marine biotechnology - Marine genomics - Marine microbiology - Bioenergy and biofuels - Marine bioproducts in industrial applications - Marine bioproducts in medical and pharmaceutical applications - and many more...
Categories: Science

Drug Selectivity

Drug Selectivity

cytoplasm at relevant concentration in order to exert their antibacterial activity, and hurdles to overcome are ... 6 Silver, L.L. (2012) Polypharmacology as an emerging trend in antibacterial discovery, in Polypharmacology in Drug ...

Author: Norbert Handler

Publisher: John Wiley & Sons

ISBN: 9783527335381

Category: Medical

Page: 536

View: 618

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Categories: Medical

Superbugs

Superbugs

Jawetz tookstock of the progress: E. Jawetz, “Antimicrobial Chemotherapy,” Annual Review of Microbiology 10 (1956): ... eds., Emerging Trends in Antibacterial Discovery: Answering the Call to Arms (Norfolk, UK; Caister Academic Press, ...

Author: Matt McCarthy

Publisher: Penguin

ISBN: 9780735217522

Category: Medical

Page: 304

View: 985

International Bestseller "An amazing, informative book that changes our perspective on medicine, microbes and our future." --Siddhartha Mukherjee, MD, New York Times bestselling author of The Emperor of All Maladies A New York Times bestselling author shares this exhilarating story of cutting-edge science and the race against the clock to find new treatments in the fight against the antibiotic-resistant bacteria known as superbugs. Physician, researcher, and ethics professor Matt McCarthy is on the front lines of a groundbreaking clinical trial testing a new antibiotic to fight lethal superbugs, bacteria that have built up resistance to the life-saving drugs in our rapidly dwindling arsenal. This trial serves as the backdrop for the compulsively readable Superbugs, and the results will impact nothing less than the future of humanity. Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more. The proverbial ticking clock will keep readers on the edge of their seats. Can Dr. McCarthy save the lives of his patients infected with the deadly bacteria, who have otherwise lost all hope?
Categories: Medical