The book (i) blends basic and clinical sciences needed to effectively demonstrate the importance of the field; (ii) includes full-color illustrations to facilitate the understanding of the essential concepts; (iii) cites references mostly ...
Author: Robert Z. Hopkins
Written in an accessible style and consistent format, "Essentials of Free Radical Biology and Medicine" takes a unique approach to integrating the fundamental principles with high quality cutting-edge research discoveries, and the basic bioscience with clinical medicine so as to provide the reader a comprehensive picture of the field in a concise manner. The book (i) blends basic and clinical sciences needed to effectively demonstrate the importance of the field; (ii) includes full-color illustrations to facilitate the understanding of the essential concepts; (iii) cites references mostly from highly influential journals to ensure the top quality of the information; (iv) uses self-assessment questions and glossary to enhance the assimilation of the cutting-edge knowledge; and (v) serves as a valuable reference or textbook for students, faculty, and other professionals in the fields of biology, pharmaceutical science, biomedical science, and clinical medicine.
New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers.
Author: Barry Halliwell
Publisher: Oxford University Press, USA
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Journal of Bioenergetics and Biomembranes. 2016 Apr 18;48(2):169-174 de
Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP. Biomarkers of free radical damage. Free Radical Biology & Medicine. 1999;26(1–2):202-226 Banes
Author: Yannis Dionyssiotis
Publisher: BoD – Books on Demand
Spinal cord injury is a severe condition leading to serious neurological dysfunctions and changes a person's life in a sudden way. Understanding the pathophysiology of spinal cord injury will improve the prognosis and reintegration to the society of spinal cord-injured subjects. The book Essentials in Spinal Cord Injury Medicine includes seven chapters with valuable information addressing hot topics related to spinal cord injury, ranging from pathophysiology, nontraumatic spinal cord injury, complications to exoskeletons, and research therapies with mesenchymal stem cells. The book could be a valued reference for physiatrists, neurosurgeons, orthopedic surgeons, neurologists and physical therapists.
Free Radical Biology & Medicine, 2009;47(12):1742-52). For more information,
contact J.S. ... cell. death. A new study, 'Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death,' is now available. “Previously, we
Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Discovery, Experimental, and Laboratory Medicine. The editors have built Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Discovery, Experimental, and Laboratory Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Discovery, Experimental, and Laboratory Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Sliskovic and colleagues published their study in Free Radical Biology and Medicine (Analysis of the mechanism by which ... For additional information,
contact I. Sliskovic, Wayne State University, Sch Medical, Dept. of Obstet &
Gynecol, CS ...
Essential Amino Acids: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Essential Amino Acids. The editors have built Essential Amino Acids: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Essential Amino Acids in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Essential Amino Acids: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Free radical Biology and Medicine 27.3/4 (1999): 309–314. Jariwalla, R.J., et al.
2008. Restoration of blood total glutathione status and lymphocyte function
following alpha-lipoic acid supplementation in patients with HIV infection. J Altern
Author: Lesley Braun
Category: Alternative medicine
Essential Herbs and Natural Supplements is an evidence-based quick reference guide. This go-to resource is essential for safe and effective clinical recommendations of herbal medicines and natural supplements. It provides current, evidence-based monographs on the 50 most commonly used herbs, nutrients and food supplements. It emphasises safe practice with strategies to prevent adverse drug reactions, guidelines in assessing benefit, risk and harm and the evaluation of research. 50 evidence-based monographs on the most used herbs and natural supplements Up-to-date evidence on the latest research impacting on herbal and natural medicine by top leaders within the fields of Pharmacy, Herbal Medicine and Natural Medicine Considerations of herbs and natural supplements in pregnancy
The biologic importance of MnSOD has been clearly demonstrated in many
studies: expression of MnSOD is essential for the ... other reactive species and
disease; in Halliwell B, Gutterridge JMC (eds): Free Radicals in Biology and Medicine.
Author: Yuji Naito
Publisher: Karger Medical and Scientific Publishers
There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.
Nebraska,. Lincoln: Proline. dehydrogenase. is. essential. for. proline. protection.
against. hydrogen. peroxide-induced. cell. death. By a News ... (Elsevier - www.
elsevier.com; Free Radical Biology & Medicine - http: //www . elsevier ...
Imino Acids—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Imino Acids—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Imino Acids—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
OXYGEN BIOLOGY AND MEDICINE Through evolution, oxygen—itself a free radical—was chosen as the terminal ... It has been established that low levels of
oxygen free radicals and reactive oxygen species are essential for some cell ...
Author: Emily Ho
Publisher: CRC Press
Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.
IOS Press Guest Editorial Free Radicals in Biology and Medicine : From
Inflammation to Biotechnology Okezie I. Aruomaa ... Whilst their production by
phagocytic cells is , of course , essential for the eradication of invading
pathogens , and the ...
Author: Okezie I. Aruoma
Publisher: IOS Press
"Oxidative stress and inflammatory cell death / tissue damage have been implicated in a wide array of human diseases, including cancer, neurodegenerative diseases, diabetes, inflammatory joint diseases,; cardiovascular dysfunctions as well as ageing. Oxidative stress mediates the activation of transcription factors such as NF?B that, in turn, induce the transcription of certain genes promoting cytokine production. Release of these cytokines results in the enhancement of inflammatory responses and activation of endothelial cells in distant organs. The inflammatory cascade is then triggered by the induction of adhesion molecules and the generation of cytokines and other inflammatory mediators. Given that reactive oxygen and nitrogen species (ROS and RNS respectively) generated by infiltrated neutrophils into distant organs act directly as noxious agents reacting with molecular components, thereby enhancing inflammatory processes and therefore influencing cell viability, ROS and RNS have become potential therapeutic targets for prophylactic biofactors. Whilst their production by phagocytic cells is, of course, essential for the eradication of invading pathogens, and the capacity of selected chemotherapeutic agents to generate such species in specific `target' cells is well known in cancer research, the novel therapeutic actions and potential mechanisms of action of ozone as a microbicidal agent in clinical dentistry are now being advocated. The focus of this publication prominently encompasses the pivotal roles of ROS and RNS in the pathogenesis of many clinical conditions (together with their involvement in the ageing process of lower (yeast) cells, and higher organisms including plants), and discusses the potential applications of dietary-derived antioxidants to interfere with the biomolecular mechanisms of these processes and hence offer realistic therapeutic or prophylactic potentials."
So that it is impossible to eliminate the active oxygen free radicals and peroxides
, and oxidative damage occurs in membrane ... The CL as a boundary lipid of
CCO in inner membrane of mitochondria is essential for maintaining the normal ...
OXYGEN BIOLOGY AND MEDICINE Through evolution, oxygen—itself a free radical—was chosen as the terminal electron acceptor for ... Other oxygen-
derived free radicals such as superoxide anion or hydroxyl radicals formed
during metabolism or by ionizing ... Their proper balance is essential for ensuring
Author: Lester Packer
Publisher: CRC Press
Micronutrients and Brain Health addresses cutting-edge research related to processes of oxidative stress that affect brain function, an area of increasing significance for those concerned and involved with public health and translational medicine. Edited by four leading micronutrient researchers, the book brings together the investigative work of more than 70 leading researchers from across the world. Chapters identify brain-specific micronutrients that support function as well as the molecular mechanisms underlying their neuroprotectant activity. These explore age-related metabolic pathways, mitochondrial nutrients, neurodegeneration and micronutrients, cell signaling, and neuronal functions. General chapters are included on brain structure, function, and metabolism, while several other chapters are devoted to the role of specific micronutrients. The book explores how brain micronutrients are found to be both metabolic and redox regulators, thereby establishing a cross-talk between the major pathways involved in modulation of cell signaling and gene expression. Specific areas of research covered include: Uses of nutritional interventions to target age-related neuronal and behavioral deficits Effects of various micronutrients on Alzheimer’s disease, including lipoic acid, green tea, and Ginkgo biloba extracts Nutrients specific to essential mitochondrial functions Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age Omega-3 fatty acids and their relation to brain function in the elderly Challenges inherent in the development of neuroprotective-neurorescue drugs This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.
In the treatment of diabetic neuropathy, the recommended dose is now 400 to
800 mg/day. For the ... Bustamante, J., et al., “Alpha-Lipoic Acid in Liver
Metabolism and Disease,” Free Radical Biology and Medicine 24: 1023–39,
1998. 5. Cameron, N. E., et al., “Effects of Alpha-Lipoic Acid in Neurovascular
Function in Diabetic Rats; Interaction with Essential Fatty Acids,” Diabetologia 41:
390–99, 1998. 6.
Author: Frank Murray
Publisher: McGraw Hill Professional
Category: Sports & Recreation
Although humans can't live forever, life can be prolonged by paying more attention to diet, lifestyle, exercise, and the supplements that are the cornerstone of today's modern medicine. 100 Super Supplements for a Longer Life highlights the many vitamins, minerals, herbs, amino acids, phytonutrients, and other natural substances that are being used to prevent and/or treat heart disease, stroke, cancer, high blood pressure, diabetes, Alzheimer's disease, aging, and other debilitating illnesses. The book includes the most up-to-date information from medical journals, scientific symposia, and other resources from around the world.
The publisher's contact information for the journal Free Radical Biology and Medicine is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-
1710, USA. (ZOlOAUG 17) Widener University, Chester: Ripples From a Stone ...
Huntington Disease: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Huntington Disease in a concise format. The editors have built Huntington Disease: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Huntington Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Huntington Disease: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Pathophysiology and Roles in Clinical Medicine David F. Horrobin ... Free Radicals in Biology and Medicine . ” Oxford : Oxford University Press , 1985 . 2 .
Horrobin DF , Begin ME . Essential fatty acids : metabolism and clinical use . In
Author: David F. Horrobin
Category: Essential fatty acids
Containing essays by leading investigators in Europe and
Author: American Institute of PhysicsPublish On: 2007-11-29
Fourth International Summer School on Nuclear Physics Methods and
Accelerators in Biology and Medicine American Institute of ... Free Radicals , Life
and Radiation Ryszard Krzyminiewski Division of Medical Physics , Faculty of
Physics , Adam Mickiewicz ... This is called metabolism and it is , of course , essential .
Author: American Institute of Physics
Publisher: Amer Inst of Physics
These proceedings are a collection of manuscripts of the lectures given at the Fourth International Summer School on Nuclear Physics Methods and Accelerators in Biology and Medicine. They provide a broad up-to-date review of the current knowledge and methods of Nuclear Physics and Particle Accelerators and their applications in medicine and biology. The material here will be of huge interest to university students of engineering, physics, medicine, and biology.
The enterosalivary concentration and circulation of nitrate and ultimately nitrite
provides an essential pathway for ... He is an active member of the Nitric Oxide
Society, Society for Free Radical Biology and Medicine and the American Heart ...
Author: Nathan S. Bryan
Publisher: DEStech Publications, Inc
This book provides a scientific analysis of the effects of foods and nutrients on the NO pathway in humans. Contributors to the book clarify novel chemical and biochemical connections between dietary intake and nitric oxide, particularly in cases of NO deficiency. In this context, the book addresses how specific foods can restore nitric oxide production and bioactivity—without medical interventions. A variety of evidential data is presented showing how NO-rich dietary elements are implicated in disease prevention and modulation. The book offers new knowledge for food technologists, food manufacturers, nutrition researchers, and healthcare practitioners. From the Foreword by Louis J. Ignarro, Nobel Laureate in Physiology/Medicine "The body of work contained in this volume, linking NO to food and nutrition, may have revolutionary implications in terms of developing strategies to combat heart disease and many other contemporary diseases associated with NO deficiency. Proving that a natural and inexpensive regimen of foods rich in nitric oxide activity does restore NO homeostasis can have profound effects on human health…The research presented in this text provides an important expansion of NO work…(and) Dr. Nathan Bryan, the editor…is to be congratulated for…communicating new knowledge and assembling the world's experts in their fields."
THE BIOLOGY OF AGING The relatively static nature of ... The free radical theory
of aging proposes that oxidative metabolism results in an excess of highly
reactive byproducts, called oxygen free radicals, which damage proteins, DNA,
Author: Ivor Benjamin
Publisher: Elsevier Health Sciences
Students, residents, and instructors swear by Andreoli and Carpenter’s Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to know to succeed on a medical rotation or residency. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the integration of molecular biology and other new horizons in medicine, familiarize you with the most current clinical concepts. An expanded International Editorial Board provides increased input from respected practitioners worldwide. Excellent images and clinical photographs vividly illustrate the appearance and clinical features of disease. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible.
Clinical , Biochemical , and Nutritional Aspects of Trace Elements . Alan R . Liss ,
Inc . N . Y . , 1982 . Aust , S . D , White , B . C : Iron Chelation Prevents Tissue
Injury Following Ischemia . Advances in Free Radical Biology and Medicine Vol .
The important developments in biochemistry presented here impinge not only on
fundamental biology, but are also of primary concern to clinical medicine and
human nutrition. Free radicals are essential to a number of normal biochemical
Author: C.A. Rice-Evans
This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.