Extrahepatic Manifestations in Liver Diseases

Extrahepatic Manifestations in Liver Diseases

The liver is of central importance to the entire organism due to its diverse functions in metabolism, its ability to detoxify and excrete, the hepatic formation and inactivation of mediators, and its involvement in non-specific defence ...

Author: R. Schmid

Publisher: Springer

ISBN: UCLA:L0067279943

Category: Medical

Page: 402

View: 277

The liver is of central importance to the entire organism due to its diverse functions in metabolism, its ability to detoxify and excrete, the hepatic formation and inactivation of mediators, and its involvement in non-specific defence mechanisms. Thus, extrahepatic manifestations of liver disease are often decisive for the disease course. In the last few years, knowledge about interaction between the liver and other organs or systems - e.g. kidneys, GI tract, skeleton, endocrine, haematopoietic and nervous sytems - has increased considerably. Thus many extrahepatic manifestations of liver disease can now be better understood and are more accessible to diagnosis and therapy. The IXth International Congress on Liver Diseases brought together experts from around the world to give information on new developments in this field which are important both for research and clinical work. These proceedings will therefore be required reading for all researchers and clinicians dealing with effectsof liver diseases on the entire organism.
Categories: Medical

Extrahepatic Manifestations of Hepatitis C Virus Infection

Extrahepatic Manifestations of Hepatitis C Virus Infection

Chronic hepatitis C virus (HCV) infection causes progressive liver fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma.

Author: Lucija Virović Jukić

Publisher:

ISBN: OCLC:1154253806

Category: Medicine

Page:

View: 827

Chronic hepatitis C virus (HCV) infection causes progressive liver fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma. Additional to liver damage, HCV infection causes a variety of systemic disorders, some of which sometimes bear more severe morbidity than the liver disease itself. These extrahepatic manifestations represent a wide spectrum of disorders, ranging from the presence of a variety of clinically insignificant autoantibodies to diseases affecting a variety of organ systems. Mixed cryoglobulinemia is a common manifestation, and associated vasculitis can affect many organs (kidney, skin, and joints). The skin can also be affected by porphyria cutanea tarda and lichen planus. Other common extrahepatic manifestations include autoimmune disorders, lymphoproliferative disorders, and a number of neurological and neuropsychiatric disorders such as fatigue, depression, or cognitive impairment. Insulin resistance, diabetes mellitus, accelerated atherosclerosis, and increased cardiovascular disease morbidity and mortality have also been associated with chronic HCV infection. The existence and severity of extrahepatic manifestations do not correlate with the severity of liver disease, and the mainstay of treatment is HCV eradication. Patients with systemic manifestations of HCV infection should be prioritized for treatment, especially in the era of new interferon-free therapies with fewer side effects.
Categories: Medicine

Hepatitis C Infection as a Systemic Disease Extra HepaticManifestation of Hepatitis C An Issue of Clinics in Liver Disease E Book

Hepatitis C Infection as a Systemic Disease Extra HepaticManifestation of Hepatitis C  An Issue of Clinics in Liver Disease  E Book

Dr. Younossi is a highly-esteemed expert in Hepatitis C Virus (HCV), and for the first time in Clinics in Liver Disease, he has compiled articles that specifically address the extrahepatic manifestation of HCV.

Author: Zobair M. Younossi

Publisher: Elsevier Health Sciences

ISBN: 9780323532402

Category: Medical

Page:

View: 850

Dr. Younossi is a highly-esteemed expert in Hepatitis C Virus (HCV), and for the first time in Clinics in Liver Disease, he has compiled articles that specifically address the extrahepatic manifestation of HCV. Articles are specifically devoted to the following topics: Hepatitis C: A Systemic Disease; Rheumatologic Manifestations of HCV; Cardiovascular Manifestations on HCV; Metabolic Manifestations of HCV (DM, Dyslipidemia); Renal Manifestations of HCV; Lymphoproliferative Disorders Associated with HCV; Depression and HCV; Neurologic Manifestations of HCV; Non-HCC Malignancies in HCV; Dermatologic Manifestations of HCV; Fatigue and Patient-reported Outcomes in HCV; Economic Burden of HCV; and Endocrine Manifestations of HCV (non-dabetes). The thorough coverage of systemic issues will give clinicians the information they need to effectively manage the HCV patient with other health issues.
Categories: Medical

Liver Disease in Children

Liver Disease in Children

The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents.

Author: Frederick J. Suchy

Publisher: Cambridge University Press

ISBN: 9781107729094

Category: Medical

Page: 752

View: 626

The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
Categories: Medical

Viral Hepatitis Chronic Hepatitis C

Viral Hepatitis  Chronic Hepatitis C

This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co ...

Author: Resat Ozaras

Publisher: Springer

ISBN: 9783030037574

Category: Medical

Page: 217

View: 834

This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed, and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately, and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.
Categories: Medical

Inflammatory Bowel Disease Pathophysiology as Basis of Treatment

Inflammatory Bowel Disease   Pathophysiology as Basis of Treatment

This book closes the gap between new findings in pathophysiology and treatment in order to better understand our current therapeutic concepts and to develop new strategies for the future.

Author: J. Schölmerich

Publisher: Springer

ISBN: 0792389964

Category: Medical

Page: 584

View: 802

Inflammatory bowel diseases are still a challenging problem in today's gastroenterology. Although their aetiology is still not understood, steady progress has been made recently in the understanding of their pathogenesis, due to the application of innovative molecular and cellular biological methods. Knowledge of the immunology of the gut and the basic mechanisms of inflammatory reactions, especially pro and anti-inflammatory mediators, the characterization of inflammatory cell types and their functions and molecules mediating cell interactions. This book closes the gap between new findings in pathophysiology and treatment in order to better understand our current therapeutic concepts and to develop new strategies for the future. It comprises the proceedings of the 67th Falk Symposium, held in Regensburg, June 1992, and contains sections on aetiology, pathophysiology, extra-intestinal mainfestations, diagnosis and treatment. It is essential reading for all clinicians treating IBD.
Categories: Medical

Schiff s Diseases of the Liver

Schiff s Diseases of the Liver

Imaging is now covered in a separate section. New clinical algorithms and drawings have been created to amplify the text and a two-color design gives the Ninth Edition of this classic a distinctive new look.

Author: Eugene R. Schiff

Publisher: Lippincott Williams & Wilkins

ISBN: 0781730074

Category: Medical

Page: 1757

View: 366

The premier clinical reference in hepatology is now in its thoroughly revised, updated Ninth Edition. More than 100 eminent contributors provide complete, current, clinically focused information on liver diseases and discuss the diagnostic tests and medical and surgical treatment options available. The Ninth Edition includes new chapters on approach to the patient with liver disease, extrahepatic manifestations of viral hepatitis, transplantation in viral hepatitis, and approach to therapy in liver disease. Imaging is now covered in a separate section. New clinical algorithms and drawings have been created to amplify the text and a two-color design gives the Ninth Edition of this classic a distinctive new look.
Categories: Medical

Hepatitis ECAB

Hepatitis   ECAB

Viral hepatitis virtually constitutes a separate etiological group. It causes a set of typical clinical, biochemical, and histological changes with or without icterus resulting from hepatic cell damage. It may be acute or chronic.

Author: Abhijit Chowdhury

Publisher: Elsevier Health Sciences

ISBN: 9788131231869

Category: Medical

Page: 132

View: 117

Hepatitis means inflammation of the liver, which can be classified as acute or chronic depending upon the duration of the condition. Various etiological agents have been correlated with the occurrence of various forms of the disease. The developed countries have a majority of drug-induced and toxic liver injury, while the developing countries like India present with a majority of feco-oral and blood borne transmissions of the disease. Viral hepatitis virtually constitutes a separate etiological group. It causes a set of typical clinical, biochemical, and histological changes with or without icterus resulting from hepatic cell damage. It may be acute or chronic. The acute form causes considerable morbidity and mortality, and the chronic sequelae may prove to be fatal by resulting in liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis A and E are transmitted feco-orally, while B and C are transmitted only through blood/secretions. Hepatitis D occurs only in association with hepatitis B. Morphological pattern of liver injury in acute hepatitis varies with etiology and severity of insult. The typical lesion in all forms of acute viral hepatitis is panlobular infiltration with mononuclear cells, predominantly lymphocytes, hepatic cell necrosis, and variable degree of cholestasis, Kupffer cell hyperplasia. In fulminant hepatic failure, massive hepatic necrosis results in a soft shrunken liver. All forms of acute viral hepatitis run similar clinical course, which include incubation period after infection during which they are asymptomatic, followed by prodromal, icteric, and convalescent phases. Extrahepatic manifestations of viral hepatitis include renal, neurological, and hematological disorders. Most patients with acute viral hepatitis recover with supportive management. Hospitalization is required only in severe cases as evidenced by prolonged PT, altered sensorium, deep jaundice with ascites. Identification of etiology of acute hepatitis is of prime importance for the treatment of hepatitis. Definitive therapy is needed in drug-induced hepatitis. Most mild forms of viral hepatitis resolve with supportive treatment. Progressive liver failure mandates urgent liver transplantation. Prognostic models (Kings’ College criteria, Clichy’s criteria) have been developed for early identification of patients who would require liver transplant.
Categories: Medical

Infections of the Liver and Biliary System An Issue of Gastroenterology Clinics of North America

Infections of the Liver and Biliary System An Issue of Gastroenterology Clinics of North America

Infections of the liver and biliary system are not uncommon, while most of the infections are viral in nature.

Author: Rajender Reddy

Publisher: Elsevier Health Sciences

ISBN: 9780323695664

Category: Medical

Page: 240

View: 591

Infections of the liver and biliary system are not uncommon, while most of the infections are viral in nature. Globally, viral hepatitis is a major public health problem and parallels infections such as HIV and tuberculosis and is associated with significant morbidity and mortality. Rapid advances have been made with HCV therapy at a time when the community focus has shifted to global elimination. This issue highlights some of the areas of considerable advances and challenges in viral hepatitis B and C. In addition, Hepatitis E is resurfacing as an infection of significance, particularly in the Western World where there is a prevalence of chronic infections. Gastroenterologists and hepatologists often think of viral hepatitis as the sole cause of hepatic infections, but there are other infections caused to bacteria, fungi and parasites; this issue highlights these infections as well. Articles are devoted to the following topics: Global epidemiology of viral hepatitis; Update on diagnostics in viral hapatitis; Heptatitis B: Immunization and impact on natural history and cancer incidence; Heptatitis B: Current status of therapy and future therapies; Hepatitis Delta: Prevalence, natural history, and treatment options; Hepatitis C: How good is real-life data and do generics work: Hepatitis C: Does successful treatment alter the natural history and quality of life; Hepatitis E: Epidemiology,clinical course, prevention, and treatment; CMV and EBV infections of the liver; Extrahepatic manifestations of viral hepatitis; Pyogenic and amebic infections of the liver; and Fungal and parasitic infections of the liver.
Categories: Medical