Haemoglobinopathy Diagnosis

Haemoglobinopathy Diagnosis

This important text: Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders Includes "test-yourself" questions and provides an indispensable tool for learning and teaching Presents new ...

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781119579953

Category: Medical

Page: 448

View: 291

An updated, essential guide for the laboratory diagnosis of haemoglobin disorders This revised and updated third edition of Haemoglobinopathy Diagnosis offers a comprehensive review of the practical information needed for an understanding of the laboratory diagnosis of haemoglobin disorders. Written in a concise and approachable format, the book includes an overview of clinical and laboratory features of these disorders. The author focuses on the selection, performance, and interpretation of the tests that are offered by the majority of diagnostic laboratories. The book also explains when more specialist tests are required and explores what specialist referral centres will accomplish. The information on diagnosis is set in a clinical context. The third edition is written by a leading haematologist with a reputation for educational excellence. Designed as a practical resource, the book is filled with illustrative examples and helpful questions that can aide in the retention of the material presented. Additionally, the author includes information on the most recent advances in the field. This important text: • Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders • Includes “test-yourself” questions and provides an indispensable tool for learning and teaching • Presents new material on antenatal screening/prenatal diagnostic services • Offers myriad self-assessment case studies that are ideal for the trainee Written for trainees and residents in haematology, practicing haematologists, and laboratory scientists, Haemoglobinopathy Diagnosis is an essential reference and learning tool that provides a clear basis for understanding the diagnosis of haemoglobin disorders.
Categories: Medical

Haemoglobinopathy Diagnosis

Haemoglobinopathy Diagnosis

diagnostic. service. General. principles. The organisation of a haemoglobinopathy service depends on the ethnic mix of the population served and also on ...

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781119579991

Category: Medical

Page: 448

View: 389

An updated, essential guide for the laboratory diagnosis of haemoglobin disorders This revised and updated third edition of Haemoglobinopathy Diagnosis offers a comprehensive review of the practical information needed for an understanding of the laboratory diagnosis of haemoglobin disorders. Written in a concise and approachable format, the book includes an overview of clinical and laboratory features of these disorders. The author focuses on the selection, performance, and interpretation of the tests that are offered by the majority of diagnostic laboratories. The book also explains when more specialist tests are required and explores what specialist referral centres will accomplish. The information on diagnosis is set in a clinical context. The third edition is written by a leading haematologist with a reputation for educational excellence. Designed as a practical resource, the book is filled with illustrative examples and helpful questions that can aide in the retention of the material presented. Additionally, the author includes information on the most recent advances in the field. This important text: • Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders • Includes “test-yourself” questions and provides an indispensable tool for learning and teaching • Presents new material on antenatal screening/prenatal diagnostic services • Offers myriad self-assessment case studies that are ideal for the trainee Written for trainees and residents in haematology, practicing haematologists, and laboratory scientists, Haemoglobinopathy Diagnosis is an essential reference and learning tool that provides a clear basis for understanding the diagnosis of haemoglobin disorders.
Categories: Medical

Variant Haemoglobins

Variant Haemoglobins

This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas.

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781444347678

Category: Medical

Page: 260

View: 509

Variant Haemoglobins – A Guide to Identification is based on the premise that any single diagnostic technique offers only a very provisional identification of a variant haemoglobin. In routine diagnostic practice two techniques are needed as a minimum, with the results being interpreted in the light of the clinical details, blood count, blood film and ethnic origin. This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas. The introductory chapters cover the genetics of haemoglobin synthesis the principles of tests employed for identification common haemoglobins of major clinical or diagnostic importance thalassaemias and related conditions The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces. For ease of reference, the atlas pages are arranged according to the retention time of each haemoglobin on HPLC, this becoming increasingly the primary technique employed in haemoglobin identification. Bringing a mix of necessary scientific expertise and clinical knowledge, each author has more than 30 years experience in the diagnosis of variant haemoglobins. Providing otherwise unavailable information, this unique and practical guide is illustrated with over 700 high quality colour digital images plus flow charts and line diagrams covers common and important haemoglobin variants, in addition to many rarer ones is an essential reference source for diagnosis in the haematology laboratory A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.
Categories: Medical

Practical Management of Haemoglobinopathies

Practical Management of Haemoglobinopathies

Bain J. Haemoglobinopathy Diagnosis. Blackwell Science, 2001. 17. British Committee for Standards in Haematology. Oxford: Guidelines on the laboratory ...

Author: Iheanyi Okpala

Publisher: John Wiley & Sons

ISBN: 9781405140201

Category: Medical

Page: 256

View: 471

Presents a comprehensive picture of care, including diagnostic, therapeutic, and psychosocial aspects. The contributors cover basic science and epidemiological aspects of the public health challenge, but maintain a focus on the day to day issues encountered in dealing with affected people. Containing clear, practical advice, this text is an essential, practical resource to bridge the gap between expensive reference texts and smaller manuals. Practical Management of Haemoglobinopathies is an ideal for; Trainees and residents in haematology Hematologists in practice Healthcare professionals treating those with sickle cell disease and thalassaemia Why Buy This Book? Deals with practical problems encountered in the comprehensive care of affected individuals Each chapter written by an expert in the field Comprehensive coverage of basic science, laboratory diagnosis, psychosocial support and community care
Categories: Medical

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies

... haemoglobinopathies by high performance liquid chromatography (HPLC): Diagnostic utility of different approaches in resource-poor settings. Clin. Chem.

Author: Stephan Lobitz

Publisher: MDPI

ISBN: 9783039216147

Category: Medical

Page: 162

View: 598

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
Categories: Medical

Frontiers in Hemoglobinopathies New Insights and Methods

Frontiers in Hemoglobinopathies  New Insights and Methods

NGS has enabled researchers to diagnose and understand complex diseases through ... Capillary zone electrophoresis for haemoglobinopathy diagnosis. J. Clin.

Author: Roberta Risoluti

Publisher: Frontiers Media SA

ISBN: 9782889667628

Category: Science

Page:

View: 764

Categories: Science

Clinical Biochemistry

Clinical Biochemistry

LABORATORY. DIAGNOSIS. OF. HAEMOGLOBINOPATHIES. The primary investigation of a haemoglobinopathy should include a full blood count, peripheral blood film ...

Author: William J. Marshall

Publisher: Elsevier Health Sciences

ISBN: 9780443101861

Category: Medical

Page: 984

View: 423

Now fully revised and updated, Clinical Biochemistry, third edition is essential reading for specialty trainees, particularly those preparing for postgraduate examinations. It is also an invaluable current reference for all established practitioners, including both medical and scientist clinical biochemists. Building on the success of previous editions, this leading textbook primarily focuses on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management - including nutritional disorders, diabetes, inherited metabolic disease, metabolic bone disease, renal calculi and dyslipidaemias. The acquisition and interpretation of clinical biochemical data are also discussed in detail. Expanded sections on haematology and immunology for clinical biochemists provide a thorough understanding of both laboratory and clinical aspects New chapters are included on important evolving areas such as the metabolic response to stress, forensic aspects of clinical biochemistry and data quality management An extended editorial team - including three expert new additions - ensures accuracy of information and relevance to current curricula and clinical practice A superb new accompanying electronic version provides an enhanced learning experience and rapid reference anytime, anywhere! Elsevier ExpertConsult.com Enhanced eBooks for medical professionals Compatible with PC, Mac®, most mobile devices and eReaders, browse, search, and interact with this title - online and offline. Redeem your PIN at expertconsult.com today! Straightforward navigation and search across all Elsevier titles Seamless, real-time integration between devices Adjustable text size and brightness Notes and highlights sharing with other users through social media Interactive content
Categories: Medical

Laboratory Hematology Practice

Laboratory Hematology Practice

Diagnosis of hemoglobinopathies: electrophoresis vs. ... five dedicated automatic devices for haemoglobinopathy diagnostics in multi-ethnic populations.

Author: Kandice Kottke-Marchant

Publisher: John Wiley & Sons

ISBN: 9781405162180

Category: Medical

Page: 770

View: 484

Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.
Categories: Medical

Midwife s Guide to Antenatal Investigations

Midwife s Guide to Antenatal Investigations

... and effects of haemoglobinopathies, how and when test results will be available, the meaning of the results and how a fetal diagnosis would be obtained.

Author: Amanda Sullivan

Publisher: Elsevier Health Sciences

ISBN: 9780702032745

Category: Medical

Page: 212

View: 304

This book serves as a guide to a comprehensive range of diagnostic screenings and tests used during pregnancy. It links routine antenatal care with specialist investigations, describing when follow up is required and how to interpret the results. Designed for ease of reference, this resource helps midwives make informed, evidence-based clinical decisions. It also provides guidance about how best to discuss sensitive issues with mothers and how to provide support to parents receiving bad news. This book is an essential resource for midwives and other health professionals involved in delivering antenatal care to women and their families. Expert contributors ensure that the information is reliable and up-to-date, and the easy-to-use format guides practitioners through each procedure, interpretation of results, and appropriate interventions. The only book of its kind, developed to provide midwives with a comprehensive guide to antenatal investigations in an accessible format. Includes a range of clinical scenarios and considers the parents' point of view, which brings the tests to life and helps midwives understand the clinical application and impact of investigations. A chapter written by the national charity ARC (Antenatal Results and Choices) relates first-hand accounts from parents whose newborns have been diagnosed with an abnormality, providing insight into how best to provide sensitive care to parents facing difficult situations. Extensive illustrations, diagrams, summary tables and ultrasound scan images make the information in the book clear and understandable. Best practice guidance from National Screening Committee (NSC) are provided to ensure all practitioners are aware of the NSC policy. Clinical guidance is supported by explanations of common and specialist terminology and developments in technology. The fundamental principles underlying genetic and chromosomal testing are described. The historical and cultural aspects of antenatal investigations are discussed, as well as the potential impact of these technologies on the future role of the midwife.
Categories: Medical

Henry s Clinical Diagnosis and Management by Laboratory Methods E Book

Henry s Clinical Diagnosis and Management by Laboratory Methods E Book

Capillary zone electrophoresis for haemoglobinopathy diagnosis, J Clin Pathol 66:29–39, 2013. Bottomley SS: Sideroblastic anaemia, Clin Haematol 11:389–409, ...

Author: Richard A. McPherson

Publisher: Elsevier Health Sciences

ISBN: 9780323755085

Category: Medical

Page: 1618

View: 889

For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.
Categories: Medical

Diagnostic Techniques in Genetics

Diagnostic Techniques in Genetics

As a consequence, a haemoglobinopathy can result either from a qualitative ... Phenotypic diagnosis of haemoglobinopathies The phenotypic diagnosis of ...

Author: Jean-Louis Serre

Publisher: John Wiley & Sons

ISBN: 9780470870266

Category: Science

Page: 270

View: 363

Recent developments within molecular biology and genetic engineering have led to huge advances and changes within the biological sciences especially within the field of human genetics. Diagnostic Techniques in Genetics offers an important overview of how DNA or RNA technology may be applied to a large set of genetic diagnoses. The first part of the book focuses on DNA/RNA applications and includes many of the latest developments in the field combined with routine procedures of genetic diagnoses, for example cloning and sequencing DNA. The DNA applications presented in the first chapter are then each applied to a specific kind of genetic diagnosis and the text concludes with a chapter devoted to population genetics. First published in French by Dunod in 2002, this book is an excellent reference for students taking courses in molecular biology, medicine and medical genetics. It is also a useful introduction for postgraduate students and researchers in the field who require a general overview of genetic diagnoses.
Categories: Science

The Midwives Guide to Key Medical Conditions

The Midwives  Guide to Key Medical Conditions

While diagnosis and management of anaemia and haemoglobinopathies are ... in the Community 8(l):57-69 Bain B J 2001 Haemoglobinopathy diagnosis: The a, b, ...

Author: Linda Wylie

Publisher: Elsevier Health Sciences

ISBN: 9780443103872

Category: Medical

Page: 178

View: 134

Collects relevant clinical information on common medical problems that can affect the pregnancy. This book covers conditions as diverse as epilepsy, lupus, diabetes and HIV. It is suitable for all health professionals dealing with childbearing women.
Categories: Medical

The Midwives Guide to Key Medical Conditions E Book

The Midwives  Guide to Key Medical Conditions E Book

While diagnosis and management of anaemia and haemoglobinopathies are ultimately the ... European Haemoglobinopathy Register 2003 Haematology Department, ...

Author: Linda Wylie

Publisher: Elsevier Health Sciences

ISBN: 9780702039850

Category: Medical

Page: 188

View: 686

The only book of its kind, this essential reference offers quick access to information on the effects medical conditions can have on pregnancy and childbirth. Coverage includes a brief overview of normal anatomy and physiology with concise, practical guidelines for managing disorders commonly seen in women of childbearing age. From mild diseases such as asthma to serious conditions such as heart lesions, this indispensable guide will help you manage pregnancy and childbirth in women with systemic disease, recognize the early onset of disease-related pregnancy complications, and determine when it may be necessary to refer patients to a specialist. Offers complete coverage of normal pathophysiology in both the general population and in the context of pregnancy and childbirth. Provides comprehensive midwifery management guidelines. Outlines potential consequences of disease-related complications for the fetus or neonate.
Categories: Medical

Haematology

Haematology

It can also be used for fetal diagnosis of haemoglobinopathy. The general area of molecular genetics is intensely technical and so very demanding of skilled ...

Author: Gary Moore

Publisher: Oxford University Press

ISBN: 9780199668861

Category:

Page: 728

View: 901

Haematology provides a broad-ranging overview of the study of blood, the dynamic fluid that interfaces with all organs and tissues to mediate essential transport and regulatory functions. Written with the needs of the biomedical scientist centre-stage, it provides a firm grounding in the physiology of blood, and the key pathophysiological states that can arise. It demonstrates throughout how an understanding of the physiologyunderpins the key investigations carried out by a biomedical scientist to forge a clear link between science and practice. The second edition includes a new chapter on acquired disorders of haemostasis.
Categories:

Clinical Diagnostic Tests

Clinical Diagnostic Tests

Haemoglobinopathy Diagnosis. 2nd ed. oxford, uK: Blackwell Publishing; 2006. Beck CE, Hall m. Rheumatoid factor and anti-CCP autoantibodies in rheumatoid ...

Author: Michael Laposata, MD, PhD

Publisher: Springer Publishing Company

ISBN: 9781617052620

Category: Medical

Page: 310

View: 941

Clinical Diagnostic Tests is a convenient, quick-reference guide to common errors and pitfalls in test selection and result interpretation for practitioners and trainees in all areas of clinical medicine. Authored by recognized experts and educators in laboratory medicine, it provides timely, practical guidance about what to doóand what not to doófor practitioners ordering or interpreting clinical tests. Each topic features a concise overview and summary followed by a list of bulleted ìstandards of careî that will enable practitioners to quickly recognize and avert a potential problem. Organized for easy access to critical information, this pithy guide addresses all major issues practitioners are likely to encounter during their day-to-day clinical work. It is intended for practitioners in pathology, laboratory medicine, primary care as well as nurse practitioners and physician assistants. It is also a valuable resource for clinical trainees and students who need to learn effective, efficient use of the clinical lab in practice. Key Features: Provides practical guidance for avoiding common errors and pitfalls in lab test selection and interpretation Includes pithy overviews and recommendations for quick reference Written by expert authors and educators in laboratory medicine Presents bulleted ìstandards of careî Serves as a concise, to-the-point teaching guide About the Author: Michael Laposata, MD, PhD , is Chair of Pathology, Director of Division of Laboratory Medicine and Clinical Laboratories, University of Texas Medical Branch, Galveston
Categories: Medical

Diagnostic Molecular Pathology in Practice

Diagnostic Molecular Pathology in Practice

Bain BJ (2006) Haemoglobinopathy diagnosis, 2nd edn. Blackwell Science, Oxford Clinical Background A 10-year-old Caucasian male returned with his parents 22 ...

Author: Iris Schrijver

Publisher: Springer Science & Business Media

ISBN: 3642196772

Category: Medical

Page: 339

View: 102

This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.
Categories: Medical

Molecular Diagnostics

Molecular Diagnostics

Ever since their introduction and further development, molecular diagnostic technologies have played a crucial role in the diagnosis of haemoglobinopathies.

Author: E. van Pelt-Verkuil

Publisher: Springer

ISBN: 9789811045110

Category: Medical

Page: 237

View: 434

This two volume book set provides a comprehensive and practical overview of the state-of-the-art molecular biological diagnostic strategies that are currently used in a wide variety of disciplines. The volumes cover: Clinical microbiology and virology Clinical chemistry Pathology Veterinary medicine Plant Pathology Food safety The two volumes are written by experts in their respective fields, who have, together with the editors, combined years of experience in the development, application and quality control of molecular diagnostic methods. The first book is devoted to the theory and backgrounds of molecular techniques, amplification technology, next generation sequencing and bioinformatics for molecular laboratory diagnostics. As a fundament of reliable molecular diagnostic assays, the quality control required for validation, implementation and performance of molecular diagnostic assays is extensively discussed. The second book highlights the applications of these methods in the various diagnostic laboratories. These two full-colour well-illustrated volumes are particularly valuable for students, clinicians, scientists and other professionals who are interested in (designing) molecular diagnostic tests and for those who wish to expand their knowledge on the current molecular biological revolution. The extensive information in both books highlights the current trend of the integration of multiple (clinical) disciplines into one universal molecular laboratory.
Categories: Medical