Author: Mary Mehrnoosh Eshaghian-WilnerPublish On: 2016-06-09
10.5.1 Immunostimulation If medical nanorobots are not appropriately biocompatible, there is a risk of a number of complications within the host. The two very broad categories of immune responses to nanoparticles are immunostimulation ...
Author: Mary Mehrnoosh Eshaghian-Wilner
Publisher: John Wiley & Sons
Provides a comprehensive overview of wireless computing in medicine, with technological, medical, and legal advances This book brings together the latest work of leading scientists in the disciplines of Computing, Medicine, and Law, in the field of Wireless Health. The book is organized into three main sections. The first section discusses the use of distributed computing in medicine. It concentrates on methods for treating chronic diseases and cognitive disabilities like Alzheimer’s, Autism, etc. It also discusses how to improve portability and accuracy of monitoring instruments and reduce the redundancy of data. It emphasizes the privacy and security of using such devices. The role of mobile sensing, wireless power and Markov decision process in distributed computing is also examined. The second section covers nanomedicine and discusses how the drug delivery strategies for chronic diseases can be efficiently improved by Nanotechnology enabled materials and devices such as MENs and Nanorobots. The authors will also explain how to use DNA computation in medicine, model brain disorders and detect bio-markers using nanotechnology. The third section will focus on the legal and privacy issues, and how to implement these technologies in a way that is a safe and ethical. Defines the technologies of distributed wireless health, from software that runs cloud computing data centers, to the technologies that allow new sensors to work Explains the applications of nanotechnologies to prevent, diagnose and cure disease Includes case studies on how the technologies covered in the book are being implemented in the medical field, through both the creation of new medical applications and their integration into current systems Discusses pervasive computing’s organizational benefits to hospitals and health care organizations, and their ethical and legal challenges Wireless Computing in Medicine: From Nano to Cloud with Its Ethical and Legal Implications is written as a reference for computer engineers working in wireless computing, as well as medical and legal professionals. The book will also serve students in the fields of advanced computing, nanomedicine, health informatics, and technology law.
More recently, endogenous host products which can play a role in nonspecific immunity, such as thymic hormones, have also been identified, produced and used both experimentally and clinically. It therefore seemed worthwile to Drs.
Author: L. Chedid
Publisher: Springer Science & Business Media
The discovery of specifically acquired immunity which followed the major contributions of Louis Pasteur completely over-shadowed the first studies of the host's natural resistance. Later, the exquisite sensitivity and precision of antigen-antibody reactions made the study of immunochemistry much more attractive than the rather primitive and ambiguous field of non-specific immunity. Neverthe less, during the last three decades, a considerable body of informa tion was developed and also means by which natural resistance could be enhanced or depressed by exogenous agents such as lipopolysaccharides or BCG. An important advance was the chemical recognition of the biologically active components of these agents which in turn allowed the synthesis or" analogues. More recently, endogenous host products which can play a role in nonspecific immunity, such as thymic hormones, have also been identified, produced and used both experimentally and clinically. It therefore seemed worthwile to Drs. Miescher and Mueller-Eberhard to devote two volumes of Seminars in Immunopathology to the topic of Immunostimuhltion. Because of the good response obtai ned from readers, Springer Verlag decided to issue a hard cover book and asked their guest editor to make a preface. Prefaces, although they are found in the opening pages, are always written after the first issue has been completed.
... Hypersensitivity Unintended immunostimulation or immunosuppression Unintended immunostimulation or immunosuppression Type II hypersensitivity Unintended immunostimulation or immunosuppression Unintended immunostimulation or ...
Author: Shayne Cox Gad
Publisher: John Wiley & Sons
Drug Safety Evluation Comprehensive and practical guide presenting a roadmap for safety assessment as an integral part of the development of drugs and therapeutics This fourth edition of Drug Safety Evaluation maintains the central objective of presenting an all-inclusive practical guide for those who are responsible for ensuring the safety of drugs and biologics to patients, healthcare providers, those involved in the manufacture of medicinal products, and all those who need to understand how the safety of these products is evaluated and shepherding valuable candidates to market. Individual chapters address specific approaches to evaluation hazards, including problems that are encountered and their solutions. Also covered are the scientific and philosophical bases for evaluation of specific concerns (e.g., carcinogenicity, development toxicity, etc.) to provide both understanding and guidance for approaching the new problems that have come to face both our society and the new challenges they brought. The many changes in regulatory requirements, pharmaceutical development, technology, and the effects of Covid on our society and science have required both extensive revision to every chapter and the addition of four new chapters. Specific sample topics covered in Drug Safety Evaluation include: The drug development process and the global pharmaceutical marketplace and regulation of human pharmaceutical safety Sources of information for consideration in study and program design and in safety evaluation Electronic records, reporting and submission, screens in safety and hazard assessment, and formulations, routes, and dosage regimens Mechanisms and endpoints of drug toxicity, pilot toxicity testing in drug safety evaluation, and repeat dose toxicity Genotoxicity, QSAR tools for drug safety, toxicogenomics, nonrodent animal studies, and developmental and reproductive toxicity testing An appendix which provides an up to date guide to CROs for conducting studies Drug Safety Evaluation was written specifically for the pharmaceutical and biotechnology industries, including scientists, consultants, and academics, to show a utilitarian yet scientifically valid path to the everyday challenges of safety evaluation and the problem solving that is required in drug discovery and development.
11.2.2 Unintended Immunostimulation As for immunosuppression, immunostimulation may be an intended primary pharmacodynamic action of drugs. Immunostimulation may be a well justified therapeutic measure in situations of selective ...
Author: Shayne Cox Gad
Publisher: John Wiley & Sons
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Statistical analysis showed statistically significant differences in TLR4 mRNA expression after immunostimulation. The initial expression of TLR7 mRNA before first suckling was higher in Group C. In Group E, the highest level of ...
Author: Bianca Castiglioni
Wood surface attributes can be established by examining its several different physical or chemical properties. Differences in the wood surfaces occur between the manufacturing and post-treatment processes as well. Understanding how their unique anisotropic molecular organization, chemical linkages, branching, and other molecular features govern micro- and macroscale accessibility is essential for coating and complex modification processes. It is therefore important for scientific as well as practical reasons to qualify and quantify the effects of wood surface treatments and modifications. Challenges still exist to fully understanding the effect of the numerous applied chemicals and the wide range of treatment processes on wood surfaces.
This is because immunostimulation from an ingested RNA would require absorption of a sufficient concentration for induction of the response, a phenomenon that is improbable given the multitude of biological barriers to the attainment of ...
Dermatomyositis C Thymus extract is of interest for treatment of dermatomyositis (inflammation of the muscles) because of its role in immunostimulation. However, clinical evidence is insufficient to support this use.
Author: Natural Standard
Publisher: Elsevier Health Sciences
Covering 400 herbs and supplements, Natural Standard Herb & Supplement Guide: An Evidence-Based Reference provides the high-quality, up-to-date, unbiased information you need to advise your patients. No other book can match its expertise and attention to evidence! Each monograph is concise and easy to read, and includes uses, dosage information, safety considerations, and interactions with drugs and other herbs and supplements. At-a-glance research summaries and an alphabetical organization allow for quick lookup in busy settings! Monographs for the 400 most commonly used and prescribed herbs and supplements — such as arnica, ginseng, lavender, glucosamine, and blue cohosh — provide the information you need for effective clinical decision-making. A unique, evidence-based A-F grading scale evaluates the efficacy of each herb and supplement. Unique! Rating scales show at a glance the quality of available evidence. Updates are peer-reviewed, and include new scientific evidence, dosage recommendations, and more. Dosing information includes dosages for adults and children, and methods for administering. Coverage of allergies, side effects/warnings, and pregnancy/breast-feeding promotes safety by indicating when specific herbs and supplements should not be used, or when caution is required. A review of evidence includes detailed explanations of clinical trials cited and conclusions drawn, especially as they relate to specific diseases and conditions. Evidence tables summarize clinical trial data and provide a quick reference for clinical decision-making. Unique! Cross-referencing by condition and scientific evidence grade provides a convenient decision support tool, making it easy to find the herbs and supplements that may be used for the treatment of particular conditions.
LA : Fr XS : LI TI 283E9 638 AU со LA : 8 8 DOCUMENT NUMBER AGR84-093647 IN NO Fr Recent advances in cattle immunology , practical applications ( vaccination immunostimulation , immunodepression ) ( 6-7 October 1983 , Lyon ( France ) ) ...
Immunostimulation. by. RNA. RNA-based therapeutic strategies include gene silencing with siRNA and modulating immunity with immunostimulatory RNA (isRNA). The development of RNA-based drugs needs to address pharmacokinetics, ...
Author: Stefan Bauer
Publisher: Springer Science & Business Media
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.