"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that ...

Author: Edward A. Dennis

Publisher: Academic Press

ISBN: 9780123822154

Category: Science

Page: 550

View: 345

Download »

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Cell Signaling Collection Edward A. Dennis, Ralph A. Bradshaw. Since cell signaling is a major area of biomedical/ biological research and continues to advance at a very rapid pace, scientists at all levels, including researchers, ...

Author: Edward A. Dennis

Publisher: Academic Press

ISBN: 9780123822161

Category: Science

Page: 540

View: 416

Download »

Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Cell Signaling Collection Edward A. Dennis, Ralph A. Bradshaw ... Transduction Mechanisms in Cellular Signaling, Regulation of Organelle and Cell Compartment Signaling, and Intercellular Signaling in Development and Disease.

Author: Edward A. Dennis

Publisher: Academic Press

ISBN: 9780123838629

Category: Science

Page: 604

View: 178

Download »

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Cell Signaling Collection Ralph A. Bradshaw, Edward A. Dennis ... Transduction Mechanisms in Cellular Signaling, Regulation of Organelle and Cell Compartment Signaling, and Intercellular Signaling in Development and Disease.

Author: Ralph A. Bradshaw

Publisher: Academic Press

ISBN: 9780123822147

Category: Science

Page: 550

View: 443

Download »

This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix

Cell Signaling Collection Ralph A. Bradshaw, Edward A. Dennis ... Transduction Mechanisms in Cellular Signaling, Regulation of Organelle and Cell Compartment Signaling, and Intercellular Signaling in Development and Disease.

Author: Ralph A. Bradshaw

Publisher: Academic Press

ISBN: 9780123822123

Category: Science

Page: 456

View: 374

Download »

A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

“Wnt signaling in development,” in Intercellular Signaling in Development and Disease: Cell Signaling Collection, Chap. 21, eds E. A. Dennis and R. A. Bradshaw (San Diego: Academic Press), 215–220. Sadowska, G. B., Malaeb, S. N., ...

Author: Nicholas Barnes

Publisher: Frontiers Media SA

ISBN: 9782889638567

Category:

Page: 286

View: 689

Download »

I am delighted to write a preface for this Celebratory eBook published in the Specialty Section Neuropharmacology, within the journal Frontiers in Pharmacology. The eBook delivers a compendium of high impact papers published previously in the journal over the last ten years; at the time of writing this collection of 20 papers has been viewed 700k times with over 75k downloads. Clearly this Section is delivering a useful resource to the scientific and medical research community! The scope of the Specialty Section Neuropharmacology is deliberately broad. We encourage submission of high quality and impactful papers in the field of neuropharmacology along the full length of the translational escalator; from cellular and molecular investigations to clinical trials. I believe this is a real strength of the Section and helps attract a diverse readership that builds the stakeholder network to promote further engagement of the Section with the research community. I have no doubt that this has contributed to the growth of the Section with submissions and accepted papers displaying 10-year (2009-2019) compound annual growth rates (CAGRs) of 58% and 78%, respectively. Vitaly, high quality, scientific rigour and impact are fundamental to a paper being accepted and this inevitably leads to a relatively high level of rejection, but the transparency of the review process means a fair decision is reached. Essential for the handling and considered review of submitted papers, the Specialty Section Neuropharmacology has a dynamic cohort of Associate Editors that have been selected carefully (81 at the time of writing) that represent the full spectrum of neuropharmacology as well as being widespread geographically around the globe. The Associate Editors are supported by nearly 500 Review Editors that ensures informed review – indeed the relatively open and interactive review process often adds considerably to the accepted version of the paper. As we celebrate the success of Frontiers in Pharmacology and the Specialty Section Neuropharmacology with this eBook, we must also recognise and be thankful for the hard work and dedication of those in the Editorial Office; their enthusiasm and willingness to help is outstanding and they form an integral component of the overall team that delivers the success. I look forward to further success for the Specialty Section Neuropharmacology. Happy reading! Professor Nicholas M. Barnes, FBPhS Specialty Chief Editor, Neuropharmacology

This book is the first of its kind to highlight the recent progress in understanding gap junction structure, and discuss the specific roles of individual connexins.

Author: Gail Cardew

Publisher: John Wiley & Sons

ISBN: 9780470515594

Category: Science

Page: 296

View: 238

Download »

Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases.

Author:

Publisher: Academic Press

ISBN: 9780128155622

Category: Medical

Page: 462

View: 833

Download »

Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more. Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms Targeted to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and tables

The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling.

Author: Sajal Ray

Publisher: BoD – Books on Demand

ISBN: 9781838800659

Category: Science

Page: 85

View: 285

Download »

Intracellular signal transduction is an important topic of research in cell and molecular biology. It has a wide range of implications in growth, differentiation, development, animal polarity, cellular response monitoring, and many disease processes, including cancer. The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling. Issues such as information thermodynamics, master regulation of immune tolerance, genetically encoded reporter circuits and their applications, hypoxia, and vitamin K2 mediated signaling processes are addressed and discussed by eminent researchers of the field.

Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.

Author: Elke Winterhager

Publisher: Springer Science & Business Media

ISBN: 9783540286219

Category: Science

Page: 289

View: 292

Download »

Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.