Intracellular Messengers

Intracellular Messengers

However, after depletion by agonist stimulation, the pool could be rapidly replenished from outside the cell, even in the absence of agonists and (presumably) intracellular messengers, such as Ins(1,4,5)P3 (Aub et al., 1982).

Author: C.M. Taylor

Publisher: Newnes

ISBN: 9780080966946

Category: Science

Page: 508

View: 841

This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers". Extracellular stimuli ("first messengers") bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers ("second messengers") which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers", and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.
Categories: Science

Extracellular and Intracellular Messengers in the Vertebrate Retina

Extracellular and Intracellular Messengers in the Vertebrate Retina

... pages 269-300 1989 Alan R. Liss , Inc. LIPID - DERIVED METABOLITES AS POSSIBLE RETINA MESSENGERS : ARACHIDONIC ... of biologically active metabolites that perform intracellular or intercellular roles as mediators or messengers .

Author: Dianna A. Redburn

Publisher:

ISBN: UOM:39015013207934

Category: Cell interaction

Page: 336

View: 440

Categories: Cell interaction

Lipid Second Messengers

Lipid Second Messengers

Messengers generated from lipids can function either as intracellular or intercellular messengers. In each case, the signal is generated by an enzyme catalyzing the conversion of the “reservoir” lipid to the messenger.

Author: Robert M. Bell

Publisher: Springer Science & Business Media

ISBN: 9781489913616

Category: Science

Page: 316

View: 314

Lipids traditionally have been viewed as serving two functions: to form cellular membranes and to serve as energy stores. During the last two decades, a new role for lipids has taken center stage: lipids can act as signalling molecules. This book deals with a variety of lipids that have been shown to be messengers. Leading scientists explore all known lipid classes except steroid hormones. Researchers and educators in biochemistry as well as in molecular and cellular biology will appreciate this volume.
Categories: Science

From Messengers to Molecules

From Messengers to Molecules

Introduction Ca2 + , a ubiquitous intracellular messenger , controls almost everything we do ( from fertilization to death ) , including how our minds organize thoughts sufficiently well to investigate our own existence , and for an ...

Author: Gernot Riedel

Publisher: Springer Science & Business Media

ISBN: 0306478625

Category: Medical

Page: 646

View: 994

The decade of the brain has brought us a few steps closer to some of the key questions in neuroscience. The complexity of memory is seen on the systems and cellular level, and different types of memory are implemented in several cellular changes that can interact, or work independently. From Messengers to Molecules: Memories are Made of These, follows the arguments from different research teams for their particular area of expertise. All chapters are written to stand-alone and provide an up-to-date introduction to the topic for both specialists and novices alike. As a result, a comprehensive compendium covering cellular mechanisms contributing to memory formation in an unusual breadth has emerged. This books will be of interest to researchers working on the pharmacology, physiology and genetics of memory formation, clinicians memory disorders, industry and students in advanced courses in Neuroscience or Pharmacology.
Categories: Medical

Biochemical Messengers

Biochemical Messengers

The alternative mechanism, used in a few cases for Ca2+-mediated processes, is that an intracellular messenger binds directly to a target protein, or to a binding protein (e.g. calmodulin) which itself binds to a target protein.

Author: D. Hardie

Publisher: Springer Science & Business Media

ISBN: 9789401131087

Category: Science

Page: 311

View: 534

The central theme of this book is that systems of cell-cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believe it to be unfortunate that there is not a collective term to describe neurotransmitters, hormones, local mediators and growth factors, other than clumsy phrases such as "extracellular signal molecule". The lack of a short and distinctive word for these entities genuinely hampers people from thinking about them in an integrated way. Having decided that it was presumptuous to invent a new term, I have chosen in this book the term first messenger to cover all types of extracellular signal molecule, because of the widespread acceptance of the term second messenger to represent the intracellular signal molecules that are produced in response to many of them. I have given the book the title "biochemical messengers", which is a global term to cover both first and second messengers. The impetus for writing the book came, as must often be the case, when I had to put together a course on cell-cell signalling for biochemistry students at the University of Dundee.
Categories: Science

Fundamentals of Intracellular Calcium

Fundamentals of Intracellular Calcium

Thus, IP3 the 'second' messenger, extracellular histamine or ATP being the first, the primary stimulus. ... Other intracellular messengers include cyclic GMP, nicotinic acid adenine dinucleotide phosphate (NAADP), cyclic ADP ribose, ...

Author: Anthony K. Campbell

Publisher: John Wiley & Sons

ISBN: 9781118942024

Category: Science

Page: 464

View: 778

The definitive text on the key component for cell functions—intracellular calcium This comprehensive book reveals the evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells. It shows how the components required for calcium signaling are named and classified; covers the technology that has been developed to study intracellular calcium; describes how calcium is regulated inside cells and how it works to trigger an event; explains the role of intracellular calcium in disease, cell injury, and cell death; reveals how many drugs work through the calcium signaling system; and demonstrates how intracellular calcium is involved in the action of many natural toxins. The book also illustrates how the intracellular calcium signaling system has evolved over millions of years, showing why it was crucial to the origin of life. Additionally, the book promotes the importance of the molecular variation upon which the intracellular calcium signalling system depends. Featuring more than 100 figures (including detailed chemical structures as well as pictures of key pioneers in the field), a bibliography of some 1000 references, and a detailed subject index, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond. Emphasizes two key scientific principles—the first to show how intracellular Ca2+ acts as a switch, to activate a wide range of cellular events, and the second demonstrating how an analogue mechanism can be superimposed on such a process Written by an internationally recognized expert in the field Filled with images and references to facilitate learning Fundamentals of Intracellular Calcium is an all-important text for post-graduate students and researchers working in biomedicine and biochemistry. It is also essential for undergraduate lecturers and their students in physiology, medicine, pharmacy, and the biosciences.
Categories: Science

Cell Signal Transduction Second Messengers and Protein Phosphorylation in Health and Disease

Cell Signal Transduction  Second Messengers  and Protein Phosphorylation in Health and Disease

Thus, phospholipase C-8 activation, through G protein-coupled receptor, and phospholipase C-y activation, tyrosine kinase mediated, produce intracellular second messengers, namely inositol 1,4,5-triphosphate (IP3) and diacylglycerols ...

Author: A.M. Municio

Publisher: Springer Science & Business Media

ISBN: 9781461518792

Category: Science

Page: 256

View: 794

It is the great glory as it is also the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute. Peter Medawar, "The Threat and the Glory" An international symposium on "Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease" was held at EI Escorial (Spain) from July 5-9, 1993 as a summer course of the Complutense University in Madrid. The lectures were delivered by renowned scientists from Europe, America, and Asia and attended by a large number of young scientists and graduate students from many countries. During evolution multicellular organisms have developed the most sophisticated and heterogeneous signals to maintain in harmony their multiple functions. The latest and most controversial aspects and developments in signal transduction were the main focus of this course. The communication among participants was extremely fluid, alive, and warm. This allowed the understanding of the key steps in cellular communication, from their original and historical sources to the main present hypothesis in the borderline of the latest scientific discoveries in this field. Without any doubt, the special atmosphere of the place, the monuments and the old granite stones, the "patio" with the fountain and the rose garden were responsible for the cordial meeting. This book comprises the manuscripts of the participants and we hope it will contribute to our knowledge of cellular signal transduction and be of value to a wider scientific community.
Categories: Science

Salivary Gastric Pancreatic and Hepatobiliary Secretion

Salivary  Gastric  Pancreatic  and Hepatobiliary Secretion

Because cellular regulation of pancreatic secretion in its main steps (i.e., receptor binding, intracellular messenger action, and cellular protein phosphorylation) are reviewed in the chapter by Williams, Burnham, and Hootman in this ...

Author: John G. Forte

Publisher: Amer Physiological Society

ISBN: 0195208161

Category: Science

Page: 800

View: 698

The third volume in The Gastrointestinal System reflects the expansion of knowledge of the cell physiology of secretion. Each chapter, grouped by traditional anatomical location, was written emphasizing the cellular bases of secretion and includes a review of the broader as well as the more integrative aspects of secretion.
Categories: Science

Excitatory Amino Acids and Second Messenger Systems

Excitatory Amino Acids and Second Messenger Systems

12 Regulation of Glial Kainate Receptor Function by Extracellular Ligands and Intracellular Messengers* Arturo Ortega, Maria L. Cotrina and Vivian I. Teichberg 12.1 Introduction 12.2 Phosphorylation and Sensitization of the KA Receptor ...

Author: Vivian I. Teichberg

Publisher: Springer Science & Business Media

ISBN: 9783662226667

Category: Medical

Page: 186

View: 875

This book deals with the mechanisms through which glutamate, the principal excitatory neurotransmitter in the mammalian central nervous system, modifies neuronal membrane functions and intraneuronal functions. Discussed are the hypothesis that the glutamate receptor signal may be processed by archidonic acid, nitric oxide, Ca 2+ and protein kinases. A key routefor glutamate receptors in synaptic plasticity and neuronal degeneration is beeing increasingly recognized. This is one of the most important new areas of endeavor by neurobiologists. The book, written by some of the most wellknown scientists in this field, provides a comprehensive reviewof conceptual approaches along with experiments showing a link between excitation mediated by glutamate and second messenger systems.
Categories: Medical

The Neurobiology of Cocaine

The Neurobiology of Cocaine

Molecular neuroscience has constructed a complex view of synaptic transmission which includes intracellular messenger systems involving coupling factors ( G proteins ) , second messengers ( e.g. , cAMP , cGMP , Ca2 + , NO , and ...

Author: Ronald P. Hammer, Jr.

Publisher: CRC Press

ISBN: 0849383110

Category: Science

Page: 286

View: 306

Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation. This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.
Categories: Science