Microtubules

Microtubules

sive recent literature , the field of microtubule research . This study is put in its proper perspective by the fact that the author has followed this work closely over several decades . It is hoped that by covering in one monograph ...

Author: Pierre Dustin

Publisher: Springer

ISBN: UCAL:B4344181

Category: Medical

Page: 476

View: 371

The author of this remarkably comprehensive review, PIERRE DUSTIN, has performed an invaluable service in bringing to gether in one volume the observations and theory on micro tubules that have accumulated over the last fifteen years. He has understood the magnitude of the task from the beginning and has met it thoroughly and, I must say, courageously. From here on, and for many years to come, young investiga tors, and some not so young, will have a ready reference as they seek to discover what has been done and remains to be done in achieving a better understanding of these important cell components. Since the early 1960's when it became clear that the fila ments (micro tubules) making up the 9 + 2 complex of cilia and flagella were to be found very widely in cells, microtub ules have attracted an ever-increasing amount of attention. Now it is known, as reviewed in this volume, that they influ ence the morphogenesis of anisometry in the shapes of cells and cell extensions; that they function as frames for the intra cellular movement of granules and chromosomes; that they are subject to control in their assembly and disassembly by externally applied substances such as colchicine and cyclic AMP; and that they display abnormalities in their numbers and orientations in transformed (malignant) cells, to mention only a few of their several functions.
Categories: Medical

Microtubules and Microtubule Inhibitors 1980

Microtubules and Microtubule Inhibitors  1980

Numerous cytoplasmic microtubules can be seen in these amoebae, many appearing to arise from the pericentriolar region of the cell (Fig. 1 (a)). It therefore seemed to us that the myxamoeba might be an interesting source of lower ...

Author: M. de Brabander

Publisher: North-Holland

ISBN: CORNELL:31924001957723

Category: Microtubules

Page: 600

View: 180

Categories: Microtubules

The Role of Microtubules as Mechanotransducers in Smooth Muscle Cells

The Role of Microtubules as Mechanotransducers in Smooth Muscle Cells

Embo J 18: 578-85, 1999. 4. Waterman-Storer, C. M., R. A. Worthylake, B. P. Liu, K. Burridge, and E. D. Salmon. Microtubule growth activates Racl to promote lamellipodial protrusion in fibroblasts [see comments]. Nat Cell Biol 1: 45-50, ...

Author: Andrew J. Putnam

Publisher:

ISBN: UOM:39015049505905

Category:

Page:

View: 474

Categories:

The Role of Microtubules in Cell Biology Neurobiology and Oncology

The Role of Microtubules in Cell Biology  Neurobiology  and Oncology

The Importance of Microtubule Dynamics to Mitosis is Central to the Chemotherapeutic Mechanism of a Large Class of Cancer Drugs The success of many microtubule-active agents as anticancer drugs is owing to their ability to affect ...

Author: Antonio Tito Fojo

Publisher: Springer Science & Business Media

ISBN: 9781597453363

Category: Medical

Page: 587

View: 850

This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.
Categories: Medical

Plant Microtubules

Plant Microtubules

P. Nick: Plant Microtubules DOI 10.1007/7089_2007_146/Published online: 24 January 2008 © Springer-Verlag Berlin Heidelberg 2008 ... the cytoskeleton comprises distinct and highly dynamic arrays of microtubules and actin microfilaments.

Author: Peter Nick

Publisher: Springer Science & Business Media

ISBN: 9783540771784

Category: Science

Page: 269

View: 986

Since the publication of the first edition of Plant Microtubules in 2000, our understanding of microtubules and their manifold functions have advanced substantially. This revised edition highlights the morphogenetic potential of plant microtubules from three general viewpoints: Microtubules and Morphogenesis, Microtubules and Environment, Microtubules and Evolution. The book is an invaluable source of information for researchers as well as for graduate and advanced students.
Categories: Science

Microtubules in vitro

Microtubules  in vitro

Already, modeling has been used to address basic questions like the function of dynamic instability and the mechanism of persistent microtubule growth in vivo. In the near future, iterative modeling and experiment will be required to ...

Author: Leslie Wilson

Publisher: Academic Press

ISBN: 0080888585

Category: Science

Page: 699

View: 189

There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This volume (complemented by the forthcoming companion volume by Cassimeris and Tran) brings together current research and protocols in the field of microtoubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. * Chapters reflect both experimental procedures and new developments in the field of microtubule in vitro research. * Combines classical approaches and modern technologies * Presents easy-to-use protocols and thorough background information, compiled by leaders in the field
Categories: Science

Microtubules in vivo

Microtubules  in vivo

The preprocessing step of our microtubule detection algorithm finds points that are likely to be inside microtubules. However, at this stage, we have not identified which points are contained in the same microtubule.

Author:

Publisher: Academic Press

ISBN: 0123813506

Category: Science

Page: 552

View: 903

Microtubules: in vivo includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton. The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation. Includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation
Categories: Science

Biological Functions of Microtubules and Related Structures

Biological Functions of Microtubules and Related Structures

serve to anchor organelles to microtubules in order to position them within the cytoplasm or to orient them with respect to other motile machinery. It is certain that the bridges link organelles to microtubules, and it is likely that ...

Author: Hikoichi Sakai

Publisher: Academic Press

ISBN: 9781483272207

Category: Science

Page: 474

View: 265

Biological Functions of Microtubules and Related Structures is a compendium of papers presented at the 13th Oji International Seminar on The Biological Functions of Microtubules and Related Structures, held at Komaba Eminence in Tokyo in November, 1981. The papers discuss the molecular function of tubulin in various biological processes or events. The book is divided into six sections focusing on the various aspects of the functions and structures of microtubules -- the biochemistry and molecular biology of tubulin, including regulation of microtubule assembly; microtubule-dynein systems and other proteins in cell motility; microtubules and related proteins in mitosis; the interactions of cytoskeletal components; the cytoskeleton; and microtubules in membrane functions and transport. Biochemists, biologists, and molecular biologists will find the book interesting.
Categories: Science

Annual Review of Biochemistry

Annual Review of Biochemistry

subunits, making it a good candidate to increase microtubule instability during mitosis (34a, 35). ... disassembly of the interphase array of microtubules in preparation for the reorganization of microtubules into the mitotic spindle.

Author:

Publisher:

ISBN: UCAL:B4943229

Category: Biochemistry

Page: 1262

View: 472

Categories: Biochemistry