Molecular Biology and Brain Ischemia

Molecular Biology and Brain Ischemia

An especially important feature of this book is the new insight it provides into the molecular neurobiology of neurotransmission, the functional structures of glutaminergic receptors, the functional proteins of synapses, and synaptic ...

Author: Koji Shimoji

Publisher: Springer Science & Business Media

ISBN: 9784431684671

Category: Medical

Page: 164

View: 922

The latest advances in molecular neurobiology have contributed significantly to understanding the pathophysiology of brain ischemia/hypoxia and have led to more effective measures to protect against ischemic brain damage. An especially important feature of this book is the new insight it provides into the molecular neurobiology of neurotransmission, the functional structures of glutaminergic receptors, the functional proteins of synapses, and synaptic plasticity. Recent progress is reported in elucidating the pathophysiological roles of NO, free radicals, and intracellular pH and calcium ions in brain ischemia/hypoxia, and a unique approach for protective and therapeutic measures against this condition is described. Molecular Neurobiology and Brain Ischemia will be of special interest to researchers and practitioners in neurobiology and related fields, including neurosurgeons.
Categories: Medical

Stroke Genomics

Stroke Genomics

Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes in gene expression to physiological endpoints-such as functional imaging paradigms-to produce a more holistic approach in which ...

Author: Simon J. Read

Publisher: Springer Science & Business Media

ISBN: 9781592598366

Category: Medical

Page: 351

View: 851

Leading experts explore the pragmatic application of the tools of genomic and molecular biology research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes in gene expression to physiological endpoints-such as functional imaging paradigms-to produce a more holistic approach in which molecular biology goes hand-in-hand with stroke pathophysiology. Topics of special interest include stem cell transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery.
Categories: Medical

Molecular Genetic And Cellular Advances In Cerebrovascular Diseases

Molecular  Genetic  And Cellular Advances In Cerebrovascular Diseases

This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation.

Author: Su Hua

Publisher: World Scientific

ISBN: 9789814723312

Category: Science

Page: 320

View: 601

This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed. Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan) Readership: Neurologists, neurobiologists, neuroscientists. Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0
Categories: Science

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS

This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field.

Author: Christian Alzheimer

Publisher: Springer Science & Business Media

ISBN: 9781461501237

Category: Medical

Page: 501

View: 639

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
Categories: Medical

Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care ...

Author: Alexander Baethmann

Publisher: Springer Science & Business Media

ISBN: 9783709194652

Category: Medical

Page: 124

View: 604

The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.
Categories: Medical

Molecular Genetics of Stroke

Molecular Genetics of Stroke

Stroke is an important clinical problem because of its large contribution to mortality.

Author: Yoshiji Yamada

Publisher: Biota Publishing

ISBN: 9781615043712

Category: Science

Page: 82

View: 148

Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.
Categories: Science

Maturation Phenomenon in Cerebral Ischemia II

Maturation Phenomenon in Cerebral Ischemia II

This book contains the presentations of the 2nd International Symposium held in Tokyo in April 1996.

Author: Umeo Ito

Publisher: Springer Science & Business Media

ISBN: 9783642605468

Category: Medical

Page: 225

View: 946

Many nerve cells of the brain which are not killed outright may suffer delayed death or recovery after ischemic insult. This fact has led to the concept of "maturation phenomenon" of neuronal injuries. Since the 1st International Symposium on Maturation Phenomenon in 1990, new developments, particularly in molecular biology, have been rapidly bringing new information about molecular nature and mechanisms of cell death. This book contains the presentations of the 2nd International Symposium held in Tokyo in April 1996. The latest developments in maturation phenomenon and the present status of investigation are described and further stimulation of research in this field is provided.
Categories: Medical

Precision Medicine in Stroke

Precision Medicine in Stroke

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine.

Author: Ana Catarina Fonseca

Publisher: Springer Nature

ISBN: 9783030707613

Category: Medical

Page: 339

View: 293

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.
Categories: Medical

Brain Injury

Brain Injury

This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke.

Author: Robert S.B. Clark

Publisher: Springer Science & Business Media

ISBN: 9781461517214

Category: Medical

Page: 384

View: 671

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.
Categories: Medical