Molecular Mechanisms of Membrane Fusion

Molecular Mechanisms of Membrane Fusion

A recent symposium which took place at the Center for Tomorrow, State University of New York at Buffalo, New York, April 27-29, 1987, was the first meeting of its kind to specifically address the molecular mechanisms of membrane fusion.

Author: Shinpei Ohki

Publisher: Springer Science & Business Media

ISBN: 9781461316596

Category: Science

Page: 588

View: 506

Membrane fusion is an important molecular event which plays a pivotal role in many dynamic cellular processes, such as exocytosis, endocytosis, membrane biogenesis, fertilization, etc. While many reports on the physico-chem1cal process involved in membrane fusion have appeared in the literature and much information has accumulated, there has been no comprehensiv~ meeting of workers in the field. A recent symposium which took place at the Center for Tomorrow, State University of New York at Buffalo, New York, April 27-29, 1987, was the first meeting of its kind to specifically address the molecular mechanisms of membrane fusion. The Symposium consisted of oral, workshop and poster presentation sessions. The papers presented in the oral and workshop sessions are collected here and arranged approximately in the order presented at the Symposium. These papers are the most up-to-date and representative work at the for front of each aspect of membrane fusion. Although the readers may find some differences in interpretations regarding the molecular mechanisms of membrane fusion, there is an over all concensus that increased hydrophobicity and dehydration of the membrane surface are essential physico-chemical factors for membrane fusion to occur. We trust that these papers will contribute to your further understanding of the mechanisms of membrane fusion.
Categories: Science

Molecular Mechanisms of Exocytosis

Molecular Mechanisms of Exocytosis

This book examines the role of key components in the exocytotic process, not only in neuronal and endocrine cells but in a variety of other relevant cell systems.

Author: Romano Regazzi

Publisher: Springer Science & Business Media

ISBN: 9780387399614

Category: Science

Page: 178

View: 743

This book examines the role of key components in the exocytotic process, not only in neuronal and endocrine cells but in a variety of other relevant cell systems. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. The book collects up-to-date reviews from the forefront of this fascinating and rapidly evolving field.
Categories: Science

Molecular Mechanisms of Membrane Traffic

Molecular Mechanisms of Membrane Traffic

This book provides a collection of participant contributions from the 1992 Summer Research Conference, "Mol ecul ar Mechani sms of Membrane Traffi c, " jointly sponsored with NATO by the American Society of Cell Biology.

Author: D. James Morre

Publisher: Springer

ISBN: 3662029308

Category: Science

Page: 418

View: 439

The study of membrane traffic in reconstituted cell-free systems has generated an unprecedented amount of new information on the biochemistry, molecular biology and genetics of membrane-based molecular events that underly normal and abnormal cellular function. Many of the individual steps have now been isolated and dissected in simple systems that permit detailed molecular analyses of transport mechanisms and their regulation. Reconstituted events of intercompartment transport include inter-membrane recognition, and controlled membrane fusion-fission reactions. Among the many advances is the growi ng awareness of a remarkabl e evolutionary conservation of many of the components involved in the many steps of membrane traffic, this realization has accelerated greatly the pace of progress in the field. This book provides a collection of participant contributions from the 1992 Summer Research Conference, "Mol ecul ar Mechani sms of Membrane Traffi c, " jointly sponsored with NATO by the American Society of Cell Biology. The conference was held May 9-13, at the Airlie Conference Center in the Virginia countryside, near Warrenton. The conference was attended by 158 scientists. A unique feature was the high proportion of young scientists among the participants. Approximately 65% were students, postdoctoral fe 11 ows and young investigators. Each attendee contri buted to the conference with either a pl atform or poster presentation.
Categories: Science

Molecular Mechanisms of Membrane Fusion at the Synapse

Molecular Mechanisms of Membrane Fusion at the Synapse

Membrane fusion is a fundamental biophysical process that facilitates synaptic transmission in both the pre- and postsynaptic terminals.

Author: John Jacob Peters

Publisher:

ISBN: OCLC:1266867606

Category:

Page:

View: 549

Membrane fusion is a fundamental biophysical process that facilitates synaptic transmission in both the pre- and postsynaptic terminals. Neurotransmitters are released from the presynaptic terminal via synaptic vesicle (SV) fusion with the presynaptic plasma membrane, while postsynaptically, neurotransmitter receptors are inserted via fusion of trafficking vesicles with the postsynaptic membrane. While the key molecules involved in SV fusion, including neuronal SNARES, the calcium sensors synaptotagmins, Munc13, Munc18, complexin, NSF, SNAPs, and many other synaptic proteins have been identified and atomic-resolution structures of some of their complexes determined, much is yet unknown about the architecture of the synaptic proteins in their native environment at the SV docking site. Recently some of the SV fusion proteins have also been found to be important for the insertion of the ionotropic, glutamatergic AMPA receptors (AMPARs) via AMPAR trafficking vesicle (ATV) fusion. However, at present, understanding of the regulation of AMPAR insertion is much more limited compared to SV fusion. In this this, I investigate the mechanisms of membrane fusion both pre- and postsynaptically.
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