New Approaches to Drug Discovery

New Approaches to Drug Discovery

AAPS J 15 (3):629–645 Reichel A (2009) Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept. Chem Biodivers 6(11):2030–2049 Reichel A (2014) Integrated approach to ...

Author: Ulrich Nielsch

Publisher: Springer

ISBN: 9783319289144

Category: Medical

Page: 341

View: 878

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.
Categories: Medical

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery

The use of experimental HTS screens as well as in silico methods for predicting polypharmacology of known drugs (Reker et al., 2014) and new molecules by means of structure-based (molecular docking, binding-site structural similarity, ...

Author: Bhushan Patwardhan

Publisher: Academic Press

ISBN: 9780128018224

Category: Medical

Page: 480

View: 836

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Categories: Medical

New Approaches Against Drug Resistant M tuberculosis

New Approaches Against Drug Resistant M  tuberculosis

published: 15 April 2021 doi: 10.3389/fmicb.2021.681420 Editorial: New Approaches Against Drug-Resistant M. ... papers and reviews describing novel approaches for drug discovery, target identification and mechanisms of drug resistance.

Author: Maria Rosalia Pasca

Publisher: Frontiers Media SA

ISBN: 9782889668694

Category: Science

Page:

View: 297

Categories: Science

Fragment based Approaches in Drug Discovery

Fragment based Approaches in Drug Discovery

Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, and HarrenJhoti 10.1 Introduction The past two decades have seen considerable interest in new approaches to smallmolecule drug discovery, aimed at expediting the identification of ...

Author: Wolfgang Jahnke

Publisher: John Wiley & Sons

ISBN: 9783527608607

Category: Science

Page: 391

View: 367

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Categories: Science

New Approaches in Cancer Pharmacology Drug Design and Development

New Approaches in Cancer Pharmacology  Drug Design and Development

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer.

Author: Paul Workman

Publisher: Springer Science & Business Media

ISBN: 9783642778742

Category: Medical

Page: 103

View: 559

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.
Categories: Medical

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery

Virtual screening: methods, expectations, and reality. Current Drug Discovery, 2, 24–28. Eckert, H., Bajorath, J. (2007). Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches.

Author: Zoran Rankovic

Publisher: John Wiley & Sons

ISBN: 0470584165

Category: Medical

Page: 308

View: 380

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Categories: Medical

New Approaches in Cancer Pharmacology Drug Design and Development

New Approaches in Cancer Pharmacology  Drug Design and Development

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer.

Author: Paul Workman

Publisher: Springer

ISBN: 3642790909

Category: Medical

Page: 97

View: 368

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.
Categories: Medical

New Approaches to Natural Anticancer Drugs

New Approaches to Natural Anticancer Drugs

The specialists in this area believe that integrating pharmacognosy and reverse pharmacognosy may provide an efficient and rapid tool for natural drug discovery, especially when the pharmaceutical industries need new drug candidates in ...

Author: Soodabeh Saeidnia

Publisher: Springer

ISBN: 9783319140278

Category: Medical

Page: 106

View: 394

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
Categories: Medical