Synthetic Chemistry of Stable Nitroxides

Synthetic Chemistry of Stable Nitroxides

Conception of nitroxide chemistry consists of the experimental methods and theoretical notions and includes as major parts 1. 2. 3. Synthesis, isolation, and purification of individual nitroxides Determination of their structure ...

Author: L. B. Volodarsky

Publisher: CRC Press

ISBN: 9781351357425

Category: Science

Page: 236

View: 115

This important book is devoted to covering the synthetic aspects of nitroxide chemistry. The problems of application and physicochemical properties of nitroxides are considered in the context of the choice of necessary radical structures, convenient precursors, and strategy of the synthesis. The book offers comparisons of the concrete classes of nitroxides to help reveal the structural peculiarities and synthetic abilities of compounds of different classes. It also summarizes data on the magneto-structural correlation for the metal complexes with 3-imidazoline nitroxides and considers the ways in which the molecular design of 2- and 3-dimensional heterospin compounds is capable of magnetic phase transfer in a ferromagnetic state. The book will be a significant reference for chemists, biochemists, spectroscopists, and other users of nitroxides, spin labels, probes, and paramagnetic ligands.
Categories: Science

Nitroxides

Nitroxides

2.3.1 Influence of Structural Factors upon Redox Properties of Nitroxides: The Fight for Stability in Biological Systems Redox properties of nitroxides play a very important role and are exploited in various applications.

Author: Didier Gigmes

Publisher: Royal Society of Chemistry

ISBN: 9781788017527

Category: Science

Page: 592

View: 862

This book covers synthesis, physicochemical studies and applications of nitroxides, showcasing the developments which have occurred in recent years.
Categories: Science

Nitroxides

Nitroxides

Gertz I. Likhtenshtein 7.1 Nitroxide Redox Probes 7.1.1 Introduction Redox reactions play a key role in fundamental chemical, photochemical, and biological processes and in the provision of energy in living organisms, in particular.

Author: Gertz I. Likhtenshtein

Publisher: John Wiley & Sons

ISBN: 9783527621750

Category: Science

Page: 438

View: 456

Covering all aspects of this field, this volume also critically discusses recent results obtained with the use of nitroxides, while providing an analysis of future developments. Written by a group of scientists with long-term experience in investigating the chemistry, physicochemistry, biochemistry and biophysics of nitroxides, the book is not intended as an exhaustive survey of each topic, but rather a discussion of their theoretical and experimental background, as well as recent advances. The first four chapters expound the general theoretical and experimental background and the advantages of modern ESR technique. Chapter 5 focuses on fundamentals and recent results in the preparation and basic chemical properties, while the next two chapters briefly outline principles and current results in nitroxides as spin probes, and as redox probes and spin traps. These chapters form the basis for the subsequent more detailed studies of nitroxides in physicochemistry, while the final chapters concentrate on the advantages of magnetic materials on the basis of nitroxides. Finally, the concluding chapter considers the rapidly developing field of biomedical, therapeutic and clinical applications. With more than 1,100 references to essential literature, this volume provides fundamental knowledge of instrumentation, data interpretation, capacity and recent advantages of nitroxide applications, allowing readers to understand how nitroxides can help them in solving their own problems.
Categories: Science

Nitroxide Spin Labels

Nitroxide Spin Labels

but the reduction rates showed the same dependence on the localization of the nitroxide moiety in the micelles as for the quenching rate constants of the merocyanine triplet state.427 In the case of 1 - dimethylaminonaphthalene - 5 ...

Author: Nickolai Kocherginsky

Publisher: CRC Press

ISBN: 084934204X

Category: Science

Page: 288

View: 430

Extending the use of nitroxides as probes into more complex systems such as viable cells and whole animals requires greater knowledge of their interactions in functioning biological systems and appropriate model systems. Nitroxide Spin Labels: Reactions in Biology and Chemistry presents information essential for research in this area. Nitroxide research offers the promise of important new ways of measuring metabolism and will be useful in the diagnosis of important disease categories such as cancer, inflammation, and ischemia.
Categories: Science

Nitroxides

Nitroxides

Beginning with an overview of the basic methodology and nitroxides’ 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field.

Author: Gertz I. Likhtenshtein

Publisher: Springer Nature

ISBN: 9783030348229

Category: Science

Page: 316

View: 935

Written by a pioneer in the development of spin labeling in biophysics, this expert book covers the fundamentals of nitroxide spin labeling through cutting-edge applications in chemistry, physics, materials science, molecular biology, and biomedicine. Nitroxides have earned their place as one of the most popular organic paramagnets due to their suitability as inhibitors of oxidative processes, as a means to polarize magnetic nuclei, and, in molecular biology, as probes and labels to understand molecular structures and dynamics AS DRAGS FOR CANCER AND OTHER DISEASES. Beginning with an overview of the basic methodology and nitroxides’ 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field.
Categories: Science

Nitroxides

Nitroxides

Chapters in this book cover the synthesis of nitroxides, EPR studies and magnetic resonance applications, physiochemical studies, and applications including in batteries, imaging and organic synthesis.

Author: Olivier Ouari

Publisher: Royal Society of Chemistry

ISBN: 9781788019668

Category: Science

Page: 592

View: 567

Nitroxides are versatile small organic molecules possessing a stabilised free radical. With their unpaired electron spin they display a unique reactivity towards various environmental factors, enabling a diverse range of applications. They have uses as synthetic tools, such as catalysts or building blocks; imaging agents and probes in biomedicine and materials science; for medicinal antioxidant applications; and in energy storage. Polynitroxides (polymers bearing pendant nitroxide sidechains) have been used in organic radical batteries, oxidation catalysts and in exchange reactions for constructing complex architectures. Chapters in this book cover the synthesis of nitroxides, EPR studies and magnetic resonance applications, physiochemical studies, and applications including in batteries, imaging and organic synthesis. With contributions from leaders in the field, Nitroxides will be of interest to graduate students and researchers across chemistry, physics, biology and materials science.
Categories: Science

Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

Nitroxide spin-labels (NSL) are stable free radicals which have one unpaired electron localized in a ... The two major classes of nitroxides tested for NMR imaging are the five-membered ring pyrrolidine nitroxides (2) and the ...

Author:

Publisher: Academic Press

ISBN: 0080583644

Category: Medical

Page: 351

View: 411

Annual Reports in Medicinal Chemistry
Categories: Medical

Nitrones Nitronates and Nitroxides Updates

Nitrones  Nitronates and Nitroxides Updates

Molecular orbitals of nitroxides using linear combination of atomic orbitals . the new bond cannot compensate for the loss of delocalization energy for the two nitroxide molecules . The gain in energy from delocalization compared to a ...

Author: Eli Breuer

Publisher: John Wiley & Sons Incorporated

ISBN: UVA:X001507540

Category: Science

Page: 435

View: 379

The structure of nitrones and the role in synthesis of nitronic acid derivatives are among the many related topics discussed in this collection of essays, focusing on the latest experimentation in nitrone research.
Categories: Science

Advances in Magnetic Resonance Imaging

Advances in Magnetic Resonance Imaging

For all of these aspects the interconversions between the nitroxides and hydroxylamines need to be considered in detail . The available data , while still insufficient for making a final decision on the pharmacological feasibility of ...

Author: Ephraim Feig

Publisher: Intellect Books

ISBN: 0893914452

Category: Medical

Page:

View: 137

Categories: Medical

The Chemistry of Radical Polymerization

The Chemistry of Radical Polymerization

1 N itroxides A wide range of nitroxides and derived alkoxyamines has now been explored for application in NMP. ... the combination:disproportionation ratio for the reaction of the nitroxide with the propagating radical (Section ...

Author: Graeme Moad

Publisher: Elsevier

ISBN: 9780080442884

Category: Science

Page: 639

View: 195

This book commences with a general introduction outlining the basic concepts of radical polymerization. This is followed by a chapter on radical reactions that is intended to lay the theoretical ground-work for the succeeding chapters on initiation, propagation and termination.
Categories: Science