Organometallics in Process Chemistry

Organometallics in Process Chemistry

This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry.

Author: Thomas J. Colacot

Publisher: Springer Nature

ISBN: 9783030279615

Category: Science

Page: 314

View: 651

This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry. This volume starts with an introduction on the historical development of organometallics in process chemistry and is followed by chapters dealing with the last five years’ development in various organometallic reaction types such as the challenging cross coupling process, construction of 3.1.0 bicycles, pressure and transfer hydrogenations of historically challenging compounds such as esters, utilization of carbon dioxide for making organic compounds by flow process, drug synthesis and metal detection and scavenging in the finished APIs. A chapter by Colacot et.al., is also devoted to the process development and structural understanding of organometallic catalysts with particular emphasis to LnPd(0) catalysts. An academia – industry collaborated chapter on the use of water as a solvent for organometallic processes is included in this book.
Categories: Science

Organometallics in Process Chemistry

Organometallics in Process Chemistry

Topics Organomet Chem ( 2004 ) 6 : 97–122 DOI 10.1007 / b94550 Development of Transition Metal - Mediated Cyclopropanation Reactions Albert J. DelMonte · Eric D. Dowdy * . Daniel J. Watson Department of Process Research and Development ...

Author: Rob Larsen

Publisher: Springer Science & Business Media

ISBN: 3540016031

Category: Science

Page: 295

View: 878

The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.
Categories: Science

Organometallics in Process Chemistry

Organometallics in Process Chemistry

This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry.

Author:

Publisher:

ISBN: 3030279626

Category: Organometallic compounds

Page: 334

View: 221

This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry. This volume starts with an introduction on the historical development of organometallics in process chemistry and is followed by chapters dealing with the last five years' development in various organometallic reaction types such as the challenging cross coupling process, construction of 3.1.0 bicycles, pressure and transfer hydrogenations of historically challenging compounds such as esters, utilization of carbon dioxide for making organic compounds by flow process, drug synthesis and metal detection and scavenging in the finished APIs. A chapter by Colacot et.al., is also devoted to the process development and structural understanding of organometallic catalysts with particular emphasis to LnPd(0) catalysts. An academia - industry collaborated chapter on the use of water as a solvent for organometallic processes is included in this book.
Categories: Organometallic compounds

Organometallics as Catalysts in the Fine Chemical Industry

Organometallics as Catalysts in the Fine Chemical Industry

Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.

Author: Matthias Beller

Publisher: Springer

ISBN: 9783642328336

Category: Science

Page: 156

View: 730

Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.
Categories: Science

Organometallic Chemistry in Industry

Organometallic Chemistry in Industry

He is a coauthor of about 100 articles, which include reviews, peer-reviewed publications, and books such as “New Trends in Cross-Coupling: Theory and Applications” (RSC) and “Organometallics in Process Chemistry – Topics in ...

Author: Thomas J. Colacot

Publisher: John Wiley & Sons

ISBN: 9783527345175

Category: Science

Page: 336

View: 150

Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.
Categories: Science

Principles of Organometallic Chemistry

Principles of Organometallic Chemistry

These elementary steps are the basic building blocks of a complex reaction, and cannot be broken down any further. The present book provides an introduction to the principles and general properties of organometallic compounds.

Author: John Baker

Publisher:

ISBN: 1645320316

Category:

Page:

View: 618

Organometallic complexes are commonly used in catalysis. Major industrial processes include hydrogenation, hydrosilylation, hydrocyanation, olefin metathesis, alkene polymerization, alkene oligomerization, hydrocarboxylation, methanol carbonylation, and hydroformylation. Organometallic intermediates are also invoked in many heterogeneous catalysis processes, analogues to those listed above. Additionally, organometallic intermediates are assumed for Fischer-Tropsch process. Organometallic complexes are commonly used in small-scale fine chemical synthesis as well, especially in cross-coupling reactions that form carbon-carbon bonds, e.g. Suzuki-Miyaura coupling, Buchwald-Hartwig amination for producing aryl amines from aryl halides, and Sonogashira coupling, etc. Organometallic compounds are very useful as catalysts or reagents in the synthesis of organic compounds, such as pharmaceutical products. One of the major advantages of organometallic compounds, as compared with organic or inorganic compounds, is their high reactivity. Reactions that cannot be carried out with the usual types of organic reagents can sometimes be easily carried out using one of a wide variety of available organometallics. A second advantage is the high reaction selectivity that is often achieved via the use of organometallic catalysts. Organometallic Compounds are chemical compounds which contain at least one bond between a metallic element and a carbon atom belonging to an organic molecule. Even metalloid elements such as silicon, tin, and boron are known to form organometallic compounds which are used in some industrial chemical reactions. Reaction mechanisms are step-by-step descriptions of what occurs on a molecular level in chemical reactions. Each step of the reaction mechanism is known as an elementary process, a term used to describe a moment in the reaction when one or more molecules changes geometry or is perturbed by the addition or omission of another interacting molecule. Collectively, an overall reaction and a reaction mechanism consist of multiple elementary processes. These elementary steps are the basic building blocks of a complex reaction, and cannot be broken down any further. The present book provides an introduction to the principles and general properties of organometallic compounds. It also supplies practical information about reaction mechanisms, along with the descriptions of contemporary applications to organic synthesis, organized by mechanism and kinetic.
Categories:

Organometallic Chemistry and Catalysis

Organometallic Chemistry and Catalysis

Fe/Cu), natural gas or petroleum residues in the presence of water vapor, which generates a mixture of CO and H2, “syngas”(“Water-Gas-Shift Reaction”, WGSR, see Chap. 20). The main industrial processes involving the use ofCO are: the ...

Author: Didier Astruc

Publisher: Springer Science & Business Media

ISBN: 9783540461296

Category: Science

Page: 608

View: 158

This volume covers both basic and advanced aspects of organometallic chemistry of all metals and catalysis. In order to present a comprehensive view of the subject, it provides broad coverage of organometallic chemistry itself. The catalysis section includes the challenging activation and fictionalization of the main classes of hydrocarbons and the industrially crucial heterogeneous catalysis. Summaries and exercises are provides at the end of each chapter, and the answers to these exercises can be found at the back of the book. Beginners in inorganic, organic and organometallic chemistry, as well as advanced scholars and chemists from academia and industry will find much value in this title.
Categories: Science

Surface and Interfacial Organometallic Chemistry and Catalysis

Surface and Interfacial Organometallic Chemistry and Catalysis

15 , 2005 Transition Metal Arene n - Complexes in Organic Synthesis and Catalysis Volume Editor : E. P. Kündig Vol . 7 , 2004 Palladium in Organic Synthesis Volume Editor : J. Tsuji Vol . 14 , 2005 Organometallics in Process Chemistry ...

Author: C. Copéret

Publisher: Springer Science & Business Media

ISBN: 3540264965

Category: Science

Page: 291

View: 834

With contributions by numerous experts
Categories: Science

Organic Synthesis

Organic Synthesis

If a metal, metal complex, or metal catalyst is used in a reaction, it must be removed from the final product. However, removal of metals to ... 88 Larsen, R. D. Ed. Organometallics in Process Chemistry; Springer: Berlin, 2004, p 264.

Author: Michael B Smith

Publisher: Academic Press

ISBN: 9780128008072

Category: Science

Page: 1106

View: 446

Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors. Fully revised and updated throughout, and teorganized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Lecture presentations and other useful material for qualified course instructors
Categories: Science