Physiology and Pharmacology of Biological Rhythms

Physiology and Pharmacology of Biological Rhythms

This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology.

Author: Peter H. Redfern

Publisher: Springer Science & Business Media

ISBN: 9783662093559

Category: Medical

Page: 668

View: 869

Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is being progressively delineated. A complete picture of the neurochemical and neuroanatomical structure of the mammalian clock is emerging and the complex pattern of control mechanisms involving endogenous clock mechan isms and photic and nonphotic zeitgebers is being built up as a result of behavioral studies. Secondly, in parallel with these exciting developments in basic science, clinical applications are being convincingly demonstrated in the general fields of pharmacology and medicine as well as in specific areas, e.g., jet lag, shiftwork maladaption syndrome, blindness, and cardiovascular system. It is therefore an opportune time to review progress in the field of chronopharmacology and to introduce some of the exciting developments and prospects to a readership beyond the confines of the chronobiological cognoscenti. This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology.
Categories: Medical

Biological Rhythms in Human and Animal Physiology

Biological Rhythms in Human and Animal Physiology

Explores the biological rhythms which govern members of the plant and animal world in their daily activities

Author: Gay Gaer Luce

Publisher:

ISBN: MINN:31951000060024R

Category: Medical

Page: 183

View: 450

Explores the biological rhythms which govern members of the plant and animal world in their daily activities
Categories: Medical

Biological Rhythms and Medicine

Biological Rhythms and Medicine

This volume is divided into seven chapters, each of which is compre hensive in its treatment and includes an extensive bibliography. The book is organized to serve as a textbook and/or reference handbook of modem applied chronobiology.

Author: A. Reinberg

Publisher: Springer Science & Business Media

ISBN: 9781461394969

Category: Medical

Page: 305

View: 897

During the past decade many review papers and books have been devoted to descriptions and analyses of biological rhythms (chronobiology) in plants and animals. These contributed greatly to demonstrating the impor tance of bioperiodicities in living beings in general. However, the practi cal aspects of chronobiology with regard to human health and improving the treatment of disease have not yet been a major focus of publication. One of our aims is to establish the relevance of biological rhythms to the practice of medicine. Another is to organize and convey in a simple fashion information pertinent to health- and life-science professionals so that students, researchers, and practitioners can achieve a clear and pre cise understanding of chronobiology. We have limited scientific jargon to unavoidable basic and well-defined terms and we have emphasized illus trative examples of facts and concepts rather than theories or hypotheti cal mechanisms. This volume is divided into seven chapters, each of which is compre hensive in its treatment and includes an extensive bibliography. The book is organized to serve as a textbook and/or reference handbook of modem applied chronobiology. Chapter 1 describes the historical development of chronobiology and reviews why, when, and how major concepts were introduced, accepted, and transformed.
Categories: Medical

Biologic Rhythms in Clinical and Laboratory Medicine

Biologic Rhythms in Clinical and Laboratory Medicine

But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine.

Author: Yvan Touitou

Publisher: Springer Science & Business Media

ISBN: 9783642787348

Category: Medical

Page: 730

View: 915

Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.
Categories: Medical

Autonomic Nervous System

Autonomic Nervous System

This book discusses the ANS from both an enlarged and a timed perspective. First, it presents how the organization of the ANS is hierarchical into different levels.

Author: Daniel Pedro Cardinali

Publisher: Springer

ISBN: 9783319575711

Category: Medical

Page: 385

View: 394

A traditional view of the Autonomic Nervous System (ANS) considers only its peripheral part: the sympathetic and parasympathetic systems. However, this view misses to consider the most important ANS function: the maintenance of homeostasis. This term is used today to define not only the strategies that allow the body proper response to changes in the environment (reactive homeostasis), but also temporal mechanisms that allow the body to predict the most likely timing of environmental stimuli (predictive homeostasis based on biological rhythms). This book discusses the ANS from both an enlarged and a timed perspective. First, it presents how the organization of the ANS is hierarchical into different levels. Following that, the book discusses how the ANS changes functionally in the three-body configurations (wakefulness, slow sleep, rapid eye movement sleep) found in a 24-hour cycle. Finally, the most important clinical implications of this enlarged and timed vision of ANS will be discussed. Autonomic Nervous System – Basic and Clinical Aspects is a comprehensive text intended for medical students and health professionals who are interested in a deeper approach to this important part of the nervous system. It provides a detailed and complete understanding of the neuroscience behind the ANS, allowing a proper clinical applicability of this knowledge.
Categories: Medical

Sleep and Sleep Disorders

Sleep and Sleep Disorders

Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this book will serve as a foundation for understanding, and ultimately treating, sleep disorders.

Author: Malcolm Lader

Publisher: Springer Science & Business Media

ISBN: 9780387276823

Category: Medical

Page: 309

View: 671

Many recent discoveries in both laboratory and clinical settings have greatly increased our understanding of sleep medicine and the relevant psychopharmacology. This timely book serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine This volume has assembled articles that summarize and review carefully, a chosen selection of the latest discoveries concerning sleep medicine, sleep physiology and sleep pharmacology. Outstanding contributions have been sought from acknowledged experts in their respective fields. The goal of the volume is to present the more recent developments and advances in the fields of sleep and neuropsychopharmacology, as well as to provide a context for considering them both in depth and from multidisciplinary perspectives. This volume brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms. Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this book will serve as a foundation for understanding, and ultimately treating, sleep disorders.
Categories: Medical

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery

Expert Opin Drug Deliv 2:667–681 Redfern PH, Lemmer B (eds) (1997) Physiology and pharmacology of biological rhythms. Springer, Heidelberg Be ́langer PM (1993) Chronopharmacology in drug research and therapy.

Author: Juergen Siepmann

Publisher: Springer Science & Business Media

ISBN: 9781461408802

Category: Medical

Page: 592

View: 492

Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.
Categories: Medical

Biological Rhythms

Biological Rhythms

Conclusion Retinal circadian rhythms in arthropods serve as a useful tool for the neurobiological analysis of the circadian ... Redfern and B. Lemmer (eds) Physiology and Pharmacology of Biological Rhythms, Hb. Exp. Pharmacol. vol. 125.

Author: Vinod Kumar

Publisher: Springer Science & Business Media

ISBN: 9783662060858

Category: Science

Page: 254

View: 986

(Chapters 11 to 14) summarise important features of the biological clock at the level of whole animal covering all vertebrate classes (fish to mammal). Chapters 15 and 16 are on long term (seasonal) rhythms in plants and higher vertebrates. Short term rhythms (ultradian rhythms), the significance of having a clock system in animals living in extreme (arctic) environments, and the diversity of circadian responses to melatonin, the key endocrine element involved in regulation of biological rhythms, have been discussed in Chapters 17 to 19. Finally, a chapter on sensitivity to light of the photoperiodic clock is added which, using vertebrate examples, illustrates the importance of wavelength and intensity of light on circadian and non-circadian functions. A well-known expert writes each chapter. When presenting information, the text provides consistent thematic coverage and feeling for the methods of investigation. Reference citation within the body of the text adequately reflects the literature as subject is developed. A chapter begins with an abstract that enables a reader to know at the first glance the important points covered in that chapter. The chapter concludes with a full citation of references included in the text, which could be useful for further reading. The book ends with a comprehensive subject index that may be useful for quick searches.
Categories: Science

Introducing Biological Rhythms

Introducing Biological Rhythms

Smolensky MH, Halberg F. (1977) Circadian rhythms in airway patency and lung volumes. ... (1989) Chronopharmacology of theophylline and beta-sympathomimetics. ... In: Physiology and Pharmacology of Biological Rhythms.

Author: Willard L. Koukkari

Publisher: Springer Science & Business Media

ISBN: 9781402047015

Category: Science

Page: 656

View: 416

Introducing Biological Rhythms is a primer that serves to introduce individuals to the area of biological rhythms. It describes the major characteristics and discusses the implications and applications of these rhythms, while citing scientific results and references. Also, the primer includes essays that provide in-depth historic and other background information for those interested in more specific topics or concepts. It covers a basic cross-section of the field of chronobiology clearly enough so that it can be understood by a novice, or an undergraduate student, but that it would also be sufficiently technical and detailed for the scientist.
Categories: Science

Nonclinical Drug Administration

Nonclinical Drug Administration

(2010) Biological rhythms in pain analgesi. In: PH Redfern and B Lemmer (Eds.) Physiology and Pharmacology of Biological Rhythm, Handbook of Experimental Pharmacology, Vol. 125. Germany: SpringerVerlag Berlin Heidelberg, pp. 619–650.

Author: Shayne C. Gad

Publisher: CRC Press

ISBN: 9781466502598

Category: Medical

Page: 420

View: 433

If we will ever achieve Paul Ehrlich’s "magic bullet," that is, a molecule which goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body, the practice of safety assessment will have to change. Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems seeks to address a trio of objectives that, though separate, are linked and central to biomedical science and, ultimately, medicine. Rather seeing these as separate "silos," those working in nonclinical safety assessment will have to view these three in an integrated manner and to regularly and thoughtfully incorporate new information and technology. The trio of objectives this book explores are: first, to present how to deliver more of a drug product systemically to facilitate the regulatory need for evaluating safety and efficacy in animal species (at elevated exposure levels) prior to advancing the drug to human testing; second is to achieve better tolerance to therapeutics administration in test animals and humans which achieves objectives 1 and 3; and third, to explore ways to improve on therapeutic target receptor delivery performance, therefore improving both clinical pharmacodynamics bioavailability and specificity. The book’s ten chapters assemble the basic concepts, principles and hypotheses involved in quantitative receptor and chronological organism interaction dynamics central to the successful development of new therapeutics which depend on systemic administration to achieve desired therapeutic goals and in so doing avoid outcomes which limit, marginalize, or preclude the therapeutic use of so many molecules.
Categories: Medical