Proteins Structure Function and Engineering

Proteins  Structure  Function  and Engineering

ter by Fink deals with compact intermediate states of protein folding, which have now been universally recognized as ... Affinity labeling is a technique that still holds great promise, not only for protein structure function analysis, ...

Author: B.B. Biswas

Publisher: Springer Science & Business Media

ISBN: 9781489917270

Category: Science

Page: 436

View: 783

Here, researchers review the latest breakthroughs in protein research. Their contributions explore emerging principles and techniques and survey important classes of proteins that will play key roles in the field's future. Articles examine the possibility of a Boltzman-like distribution in protein substructures, the new technique of Raman spectroscopy, and compact intermediate states of protein folding. This well-illustrated volume also features coverage of proteins that bind nucleic acids.
Categories: Science

Introduction to Proteins

Introduction to Proteins

These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale ...

Author: Amit Kessel

Publisher: CRC Press

ISBN: 9781498747189

Category: Computers

Page: 932

View: 725

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercies, and References. New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Each chapter includes a Summary, Exercies, and References Approximately 300 color images Downloadable solutions manual available at www.crcpress.com For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website: http://ibis.tau.ac.il/wiki/nir_bental/index.php/Introduction_to_Proteins_Book. Praise for the first edition "This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012
Categories: Computers

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research

protein structure R37GM - 30804-21 Theoretical studies of biomolecules RO1GM - 30861-09 Molecular basis of calcium ... Structural studies of protein recognition PO1GM - 37641-05 0005 Protein structure , function , and engineering at ...

Author:

Publisher:

ISBN: MINN:31951P000792327

Category: Medicine

Page:

View: 642

Categories: Medicine

Research Awards Index

Research Awards Index

S0000105 ** POIGM - 37641-02 0003 Protein structure , function , and engineering at MIT Protein stability and det.S0000105 ** PO1GM - 37641-02 0004 Protein structure , function , and engineering at MIT - Structural studies of pro.

Author:

Publisher:

ISBN: UOM:39015014022589

Category: Medicine

Page:

View: 141

Categories: Medicine

Statistical Mechanics Protein Structure and Protein Substrate Interactions

Statistical Mechanics  Protein Structure  and Protein Substrate Interactions

J. Boberg, T. Salakoski and M. Vihinen, Selection of a representative set of structures from the Brookhaven protein databank, PROTEINS: Structure, Function and Genetics, 14: 265 (1992). C. Chothia and A. M. Lesk, The relationship ...

Author: Sebastian Doniach

Publisher: Springer Science & Business Media

ISBN: 9781489913494

Category: Science

Page: 406

View: 217

A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.
Categories: Science

Protein Engineering and Design

Protein Engineering and Design

Proteins possess a broad range of structural and functional properties that are unmatched by any other class of ... Engineering an arbitrary protein structure or function remains a formidable challenge, because the rules defining ...

Author: Sheldon J. Park

Publisher: CRC Press

ISBN: 1420076590

Category: Medical

Page: 416

View: 311

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science
Categories: Medical

Protein Structure Function Relationships in Foods

Protein Structure Function Relationships in Foods

It is the goal of this book to aid in better defining these relationships.

Author: Rickey Y. Yada

Publisher: Springer Science & Business Media

ISBN: 9781461526704

Category: Technology & Engineering

Page: 202

View: 293

Food proteins constitute a diverse and complex collection of biological macro molecules. Although contributing to the nutritional quality of the foods we con sume, proteins also act as integral components by virtue of their diverse functional properties. The expression of these functional properties during the preparation, processing and storage of foods is largely dictated by changes to the structure or structure-related properties of the proteins involved. Therefore, germane to the optimal use of existing and future food protein sources is a thorough understanding of the nature of the relationships between structure and function. It is the goal of this book to aid in better defining these relationships. Two distinct sections are apparent: firstly, those chapters which address struc ture-function relationships using a variety of food systems as examples to demonstrate the intricacies of this relationship, and secondly, those chapters which discuss techniques used to either examine structural parameters or aid in establishing quantitative relationships between protein structure and function. The editors would like to thank all contributors for their assistance, co-operation and, above all, their patience in putting this volume together, and the following companies/organizations for their financial support without which it would not have been the success it was: Ault Foods Limited, Best Foods Canada Limited, Natural Sciences and Engineering Research Council of Canada, Ontario Ministry of Agriculture and Food, Quest International Canada Inc., and University of Guelph. R.Y.Y. R.LJ.
Categories: Technology & Engineering