Signal Transduction in Mast Cells and Basophils

Signal Transduction in Mast Cells and Basophils

This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that ...

Author: Ehud Razin

Publisher: Springer Science & Business Media

ISBN: 0387986251

Category: Medical

Page: 454

View: 656

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.
Categories: Medical

Signal Transduction in Mast Cells and Basophils

Signal Transduction in Mast Cells and Basophils

Interleukin-3 16 Assessing the Role of IL-3 in Mouse Mast Cell and Basophil Development Using IL-3–/– Mice 17 Kit"/Kit", IL-3–/– Mice Exhibit a Profound Impairment of Mucosal Mast Cell Development and Immunity, During Infection with ...

Author: Ehud Razin

Publisher: Springer Science & Business Media

ISBN: 9781461221548

Category: Science

Page: 423

View: 524

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.
Categories: Science

IgE Receptor Fc RI Function in Mast Cells and Basophils

IgE Receptor  Fc  RI  Function in Mast Cells and Basophils

KNOWN SIGNAL TRANSDUCTION EVENTS IN HUMAN CELLS INTRODUCTION There are an enormous number of signal transduction biochemistries known to operate in a wide variety of cell types. While a good number of these have been studied in RBL-2H3 ...

Author: Majed M. Hamawy

Publisher: Springer Science & Business Media

ISBN: 9783662220221

Category: Medical

Page: 292

View: 798

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
Categories: Medical

Mast Cells and Basophils

Mast Cells and Basophils

Galli, S. J. Signals in the regulation of mast cell growth and development: a perspective. In: Signal Transduction in Mast Cells and Basophils (Razin, E., Pecht, I. and Rivera, J. eds), in press.

Author: Gianni Marone

Publisher: Academic Press

ISBN: 9780080535852

Category: Medical

Page: 707

View: 372

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Categories: Medical

IgE Receptor Fc RI Function in Mast Cells and Basophils

IgE Receptor  Fc  RI  Function in Mast Cells and Basophils

Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Author: Majed M. Hamawy

Publisher: Springer

ISBN: 3662220245

Category: Medical

Page: 292

View: 244

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases. Written by leading scientists in the field, this book is the first comprehensive monograph to cover various aspects of FceRI structure, signal transduction and function. Thus, the book is valuable for researchers/students working on FceRI and on other receptors. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.
Categories: Medical

Mast Cells and Basophils

Mast Cells and Basophils

Presentations on early events in FceRI-mediated activation of mast cells and basophils will focus on the molecular ... include major molecules and their interactions that govern the signalling pathways stimulated by FceRI in mast cells.

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

ISBN: 9780470030516

Category: Medical

Page: 274

View: 913

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
Categories: Medical

Protein Kinases in Blood Cell Function

Protein Kinases in Blood Cell Function

I. Chapter 4 THE ROLE OF PROTEIN KINASES IN MAST CELL AND BASOPHIL FUNCTION John R. White Introduction . ABC A. B. C. D. B. C. D. E. Mast Cell Heterogeneity Receptors on the Surface of Mast Cells Signal Transduction Pathways 1 . 2 . 3 .

Author: Chi-Kuang Huang

Publisher: CRC Press

ISBN: 0849363535

Category: Medical

Page: 322

View: 123

Protein Kinases in Blood Cell Function provides an up-to-date, comprehensive review of protein kinases in various types of blood cell function. Blood cells discussed include T lymphocytes, B lymphocytes, platelets, mast cells, neutrophils, and macrophages. The book will interest pathologists, physiologists, oncologists, hematologists, leukocyte biologists, and immunologists. It will also benefit anyone interested in signal transduction and blood cell functions such as host defense, hemostasis, and immune response.
Categories: Medical

Allergy and Allergic Diseases

Allergy and Allergic Diseases

Razin E, Pecht I, Rivera J (1995) Signal transduction in the activation of mast cells and basophils. Immunol Today 16:370–373. . Siraganian RP, Hook WA, Levine BB (1975) Specific in vitro histamine release from basophils by bivalent ...

Author: Judah A. Denburg

Publisher: Springer Science & Business Media

ISBN: 9781475727760

Category: Medical

Page: 599

View: 429

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.
Categories: Medical

Wintrobe s Clinical Hematology

Wintrobe s Clinical Hematology

switching , must be recognized in any analysis of basophil and mast cell lineages . ... roles to c - kit and its ligand in signal transduction and transcription factor regulation of basophil and mast cell differentiation ( 106 ) .

Author: John P. Greer

Publisher: Lippincott Williams & Wilkins

ISBN: 0781765072

Category: Medical

Page: 1358

View: 227

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology continues to be an industry leader with its ability to correlate basic science with the clinical practice of hematology. With the first edition of Wintrobe's Clinical Hematology published in 1942 clearly establishing hematology as a distinct subspecialty of Internal Medicine, the latest edition continues the influence of the Wintrobe name and helps to set this book apart from the competition.With its strong focus on the clinical aspects of hematology, the book has generated a strong following among internists and general practitioners who want a single resource to consult for their patients who present any blood related disorder. The Twelfth Edition is in full color for the first time, boasts a new editorial team, and includes expanded coverage of new medications and four new chapters on Newborn Anemias, Pathology of LHC, Spleen Tumors, and Myeloproliferative Disorders and Mast Cell Disease. A companion Website will offer the fully searchable text and an image bank.
Categories: Medical

Patterson s Allergic Diseases

Patterson s Allergic Diseases

... of one extracellular subunit, a, which binds to IgE, and two intracellular subunits, P and y, which are associated with enzymes and are essential in the subsequent signal transduction on the activation of mast cells and basophils.

Author: Leslie C. Grammer

Publisher: Lippincott Williams & Wilkins

ISBN: 9781451148633

Category: Medical

Page: 736

View: 802

Revised and updated for its Seventh Edition, this highly acclaimed volume is a complete, current, and practical guide to the diagnosis and treatment of allergic disorders. This comprehensive yet concise reference will remain the first choice for residents and practitioners who need guidance to identify an allergy, confirm a diagnosis, or find effective therapies. It will also be an excellent aid for board review. This edition includes discussions of clinical trials in asthma and significant updates on drug allergy, imaging, occupational allergy, and immune deficiency evaluation. A Companion Website will include the fully searchable text and additional illustrations and tables.
Categories: Medical