Targeted Drug Delivery Concepts and Design

Targeted Drug Delivery   Concepts and Design

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body.

Author: Padma V. Devarajan

Publisher: Springer

ISBN: 9783319113555

Category: Medical

Page: 790

View: 220

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Categories: Medical

Advanced Drug Delivery

Advanced Drug Delivery

The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad ...

Author: Ashim Mitra

Publisher: John Wiley & Sons

ISBN: 9781118662847

Category: Medical

Page: 530

View: 728

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical sciences,chemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases. Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts: Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stability,transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell research,cell-based therapeutics, tissue engineering, and molecularimaging Each chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book. Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.
Categories: Medical

Drug Targeting And Delivery

Drug Targeting And Delivery

This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport.

Author: H.E. Junginger

Publisher: CRC Press

ISBN: 0132204681

Category: Medical

Page: 276

View: 262

This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport. It discusses a range of concepts for drug delivery systems, treating the routes of drugs with regard to their characteristics: function, structure, uptake, mechanism and effect. The book also explores the interface between pharmaceutical technology and physiological principles in drug design, a field of increased importance to industry.
Categories: Medical

Smart Polymeric Nano Constructs in Drug Delivery

Smart Polymeric Nano Constructs in Drug Delivery

The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications.

Author: Suresh P Vyas

Publisher: Academic Press

ISBN: 9780323913997

Category: Business & Economics

Page: 626

View: 243

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications
Categories: Business & Economics

Biomedical Composites

Biomedical Composites

Pattni BS, Torchilin VP (2015) Targeted drug delivery: concepts and design. In: Targeted drug delivery: concepts and design, pp 3–38 11. Alemán J et al (2007) Definitions of terms relating to the structure and processing of sols, gels, ...

Author: Amit Kumar Nayak

Publisher: Springer Nature

ISBN: 9789813347533

Category: Technology & Engineering

Page: 222

View: 961

This book provides an overview of biocomposite chemistry, chemical modifications, characterization and applications in biomedicine, with emphasis on recent advances in the field. Authored by experts, the chapters discuss the design, development and selection of biomedical composites for a particular therapeutic application, as well as providing insight into the regulatory and clinical aspects of biomedical composite use. While this book is primarily intended for scientists from the fields of medical, pharmaceutical, biotechnological and biomedical engineering, it is also useful as an advanced text for students and research scholars.
Categories: Technology & Engineering

Targeted Drug Delivery

Targeted Drug Delivery

Magic bullets fly again. Sci. Am. 285: 34–41. 3 Pattni, B.S. and Torchilin, V.P. (2015). Targeted drug delivery systems: strategies and challenges. In: Targeted Drug Delivery: Concepts and Design, Advances in Delivery Science ...

Author: Yogeshwar Bachhav

Publisher: John Wiley & Sons

ISBN: 9783527347810

Category: Science

Page: 468

View: 442

Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field. The following key topics are addressed: Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.
Categories: Science

Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I

Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I

[http://dx.doi.org/10.1016/j.addr.2012.11.006] [PMID: 23280371] [14] Thanki K, Kushwah V, Jain S. Recent advances in tumor targeting approaches. In: Devarajan PV, Jain S. Targeted drug delivery: concepts and design Springer Publishing, ...

Author: Swarnlata Saraf

Publisher: Bentham Science Publishers

ISBN: 9789815036527

Category: Medical

Page: 325

View: 241

This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery. Part I covers the following topics: - Introduction to nanotechnology and herbal-based nanoparticulate systems - Nucleic acid-based therapeutic drug delivery systems - Herbal bioactives: a booster dose for advanced pharmaceutical nanoscience - Pulmonary nano-drug delivery systems - Application of nano-drug delivery systems in improving the therapeutic efficacy of bioactive natural products - PEGylated liposomes - Insulin liposomes - Aquasomes: a promising novel drug carrier - Nanoparticle-aided herbal drugs: therapeutic implications on cholinergic dysfunction with relevance to Alzheimer’s disease - Vitamins based nanomedicine approach - Recent advances in tumor targeting drug delivery systems: fundamentals of advanced pharmaceutical nanoscience - Niosomes: a revolutionary progress in the field of pharmaceutical sciences - Infectious diseases: pharmaceutical nanoscience for targeted drug delivery This reference is a valuable resource for scholars that creates awareness of novel drug delivery systems as well as their promising applications in drug targeting, and nanotherapeutics for specific diseases.
Categories: Medical

Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery

Targeted drug delivery: Concepts and design. Springer; 2015. p. 3–38. [5] Patel S, Patel B, Patel Z, Pardeshi C. Nanocarriers as novel nose-to-brain targeted drug delivery platforms. Indian J Novel Drug Deliv 2012;4:243–51.

Author: Chandrakantsing Pardeshi

Publisher: Academic Press

ISBN: 9780128225233

Category: Business & Economics

Page: 554

View: 798

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals
Categories: Business & Economics

Retrometabolic Drug Design and Targeting

Retrometabolic Drug Design and Targeting

Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different ...

Author: Nicholas Bodor

Publisher: John Wiley & Sons

ISBN: 9781118407769

Category: Science

Page: 418

View: 793

Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Categories: Science

Drug Delivery with Targeted Nanoparticles

Drug Delivery with Targeted Nanoparticles

Adv. Drug Deliv. Rev., 65(1), 21–23. 3. Santos, H. A., et al. (2015). Inorganic nanoparticles in targeted drug delivery and imaging. In Devarajan, P. V., Jain, S. (eds.), Targeted Drug Delivery: Concepts and Design, ...

Author: Yılmaz Çapan

Publisher: CRC Press

ISBN: 9781000375305

Category: Medical

Page: 654

View: 538

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.
Categories: Medical