Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the ...

Author: Kamal Dua

Publisher: Springer Nature

ISBN: 9789813368279

Category: Medical

Page: 926

View: 112

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
Categories: Medical

Medicinal Plants for Lung Diseases

Medicinal Plants for Lung Diseases

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections.

Author: Kamal Dua

Publisher: Springer Nature

ISBN: 9789813368507

Category: Medical

Page: 622

View: 438

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.
Categories: Medical

Biomedical Translational Research

Biomedical Translational Research

In: Dua K, Löbenberg R, Malheiros Luzo ÂC, Shukla S, Satija S (eds) Targeting cellular signalling pathways in lung diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6827-9_37 Li SN, Xu YY, Gao JY, Yin HR, Zhang SL, ...

Author: R.C. Sobti

Publisher: Springer Nature

ISBN: 9789811692321

Category: Medical

Page: 597

View: 499

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
Categories: Medical

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

... Oligonucleotide therapy: an emerging focus area for drug delivery in chronic infiammatory respiratory diseases. Chem Biol Interact 308:206–215 Mehta M, Dhanjal DS, Paudel KR et al (2020b) Cellular signalling pathways mediating the ...

Author: Dinesh Kumar Chellappan

Publisher: Springer Nature

ISBN: 9789811643927

Category: Medical

Page: 655

View: 273

This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
Categories: Medical

Nanotechnology for Drug Delivery and Pharmaceuticals

Nanotechnology for Drug Delivery and Pharmaceuticals

Natural compounds targeting major signal- ing pathways in lung cancer. Targeting Cellular Signalling Pathways in Lung Diseases (pp. 821À846). Available from https://link.springer.com/chapter/10.1007/978-981-33-6827-9_37.

Author: Ravindra Pratap Singh

Publisher: Elsevier

ISBN: 9780323953269

Category: Business & Economics

Page: 474

View: 709

Nanotechnology for Drug Delivery and Pharmaceutical Sciences presents various drug-delivery techniques that utilize nanotechnology for the biomedical domain, highlighting both therapeutic and diagnostic applications. The book provides important facts and detailed studies on different promising nanocarriers like liposomes, exosomes and virus-based nanocarriers. Moreover, it explores these nanocarriers' utilization in the therapeutic applications of various diseases such as cancer, inflammation, neurodegenerative disorders like Huntington’s disease, Alzheimer's disease, human immunodeficiency virus (HIV), and inflammatory bowel disease. In addition, the book describes how nanotechnology has efficiently overtaken conventional dosage forms and provided comfort and ease to patients. Relevant information regarding market trends, patents and social-economic factors are also provided, making this the perfect reference for doctors, researchers and scientists working in the fields of medicine, biochemistry, biotechnology, nanobiotechnology and the pharmaceutical sciences. Gives a brief description of the utilization of nanotechnology in the drug-delivery domain Highlights the properties of nanocarriers, their diagnostic and imaging applications, and their potential role in clinical diagnosis Focuses on future developments and possibilities, allowing readers to enhance and explore the remaining gaps
Categories: Business & Economics

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Airway remodeling contributes to the progressive loss of lung function in asthma, an overview. ... Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update.

Author: Kamal Dua

Publisher: Academic Press

ISBN: 9780128208885

Category: Business & Economics

Page: 616

View: 854

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)
Categories: Business & Economics

Signalling Molecules as Targets in Cancer Therapy

Signalling Molecules as Targets in Cancer Therapy

This book presents state-of-the-art information on the molecules of cell signalling pathways that represent actual or future targets for cancer therapy.

Author: Vittorio de Franciscis

Publisher: Nova Publishers

ISBN: 1600212433

Category: Health & Fitness

Page: 240

View: 397

This book presents state-of-the-art information on the molecules of cell signalling pathways that represent actual or future targets for cancer therapy. By giving an update of the most promising approaches in this rapidly evolving field, the book contributes to the translation of the recent advances in the knowledge of intracellular signalling into the generation of innovative biomolecules as specific tools to target the most promising tumour-specific candidates. The book begins logically with the molecules first encountered along the signalling pathways, the membrane receptors for growth factors (Part I). Next, Part II presents several examples of intracellular molecular targets that are situated one step beyond in the pathways, while Part III addresses the difficult task of tuning the delicate balance between cell death and survival. In Part IV, the reader is taken into the practical problems raised by the therapy of specific cancers (glioma, childhood leukaemia), and into an original strategy from the field of nuclear medicine with the potential to generate innovative molecular-targeted cancer therapies.
Categories: Health & Fitness

Extracellular Targeting of Cell Signaling in Cancer

Extracellular Targeting of Cell Signaling in Cancer

Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than ...

Author: James W. Janetka

Publisher: John Wiley & Sons

ISBN: 9781119300205

Category: Science

Page: 488

View: 553

International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.
Categories: Science

Vitamin E in Health and Disease

Vitamin E in Health and Disease

2006;25(57):7461-7468 Rao TP, Kuhl M. An updated overview on Wnt signaling pathways: A prelude for more. ... mechanisms of action of dietary phytochemicals for cancer prevention by targeting cellular signaling transduction pathways.

Author: Jose Antonio Morales-Gonzalez

Publisher: BoD – Books on Demand

ISBN: 9781789842456

Category: Science

Page: 111

View: 178

In this book, Vitamin E in Health and Disease, the chapter by Dr Lisa Schmölz et al., The Hepatic Fate of Vitamin E, includes the hepatic metabolism of vitamin E, its storage, release, distribution, and its effects on the metabolism in great detail, as well as its effect on the prevention of diseases, in addition to its role in anti-aging. The chapter by Dr Rusu Anca Elena reports on the effect of vitamin E in patients with hemodialysis. In a similar manner, the chapter of Drs Rayan Ahmed and Paul W. Sylvester describe g-Tocotrienol, a natural isoform within the vitamin E family of compounds, which displays potent antiproliferative, apoptotic and reversal of epithelial-to-mesenchymal-transition activity against breast cancer, employing treatment doses that have little or no effect on normal cell viability. The chapter by Milka Mileva and Angel S. Galabov describes how vitamin E could be recommended as a reliable agent, indeed as a component in multiorgan flu therapy. Last, Dr Juan José Godina-Nava et al. describe the cytoprotector effect of the 120-Hz electromagnetic fields in early hepatocarcinogenesis.
Categories: Science

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases

23.6 Concluding Remarks The xenobiotic-metabolizing pathways and pathways of cellular signaling that lead to an ... In the search for the lung molecular pathways and targets in pulmonary damage and carcinogenesis, ROS, CYP450, COX, ...

Author: Sajal Chakraborti

Publisher: Springer Nature

ISBN: 9789811384134

Category: Science

Page: 491

View: 158

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.
Categories: Science