Targeting Cellular Signalling Pathways in Lung Diseases

Targeting Cellular Signalling Pathways in Lung Diseases

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the ...

Author: Kamal Dua

Publisher: Springer Nature

ISBN: 9789813368279

Category: Medical

Page: 926

View: 625

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
Categories: Medical

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

... Oligonucleotide therapy: an emerging focus area for drug delivery in chronic infiammatory respiratory diseases. Chem Biol Interact 308:206–215 Mehta M, Dhanjal DS, Paudel KR et al (2020b) Cellular signalling pathways mediating the ...

Author: Dinesh Kumar Chellappan

Publisher: Springer Nature

ISBN: 9789811643927

Category: Medical

Page: 655

View: 349

This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
Categories: Medical

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Airway remodeling contributes to the progressive loss of lung function in asthma, an overview. ... Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update.

Author: Kamal Dua

Publisher: Academic Press

ISBN: 9780128208885

Category: Business & Economics

Page: 616

View: 413

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)
Categories: Business & Economics

Medicinal Plants for Lung Diseases

Medicinal Plants for Lung Diseases

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections.

Author: Kamal Dua

Publisher: Springer Nature

ISBN: 9789813368507

Category: Medical

Page: 622

View: 917

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.
Categories: Medical

Vitamin E in Health and Disease

Vitamin E in Health and Disease

2006;25(57):7461-7468 Rao TP, Kuhl M. An updated overview on Wnt signaling pathways: A prelude for more. ... mechanisms of action of dietary phytochemicals for cancer prevention by targeting cellular signaling transduction pathways.

Author: Jose Antonio Morales-Gonzalez

Publisher: BoD – Books on Demand

ISBN: 9781789842456

Category: Science

Page: 110

View: 175

In this book, Vitamin E in Health and Disease, the chapter by Dr Lisa Schmölz et al., The Hepatic Fate of Vitamin E, includes the hepatic metabolism of vitamin E, its storage, release, distribution, and its effects on the metabolism in great detail, as well as its effect on the prevention of diseases, in addition to its role in anti-aging. The chapter by Dr Rusu Anca Elena reports on the effect of vitamin E in patients with hemodialysis. In a similar manner, the chapter of Drs Rayan Ahmed and Paul W. Sylvester describe g-Tocotrienol, a natural isoform within the vitamin E family of compounds, which displays potent antiproliferative, apoptotic and reversal of epithelial-to-mesenchymal-transition activity against breast cancer, employing treatment doses that have little or no effect on normal cell viability. The chapter by Milka Mileva and Angel S. Galabov describes how vitamin E could be recommended as a reliable agent, indeed as a component in multiorgan flu therapy. Last, Dr Juan José Godina-Nava et al. describe the cytoprotector effect of the 120-Hz electromagnetic fields in early hepatocarcinogenesis.
Categories: Science

Mitochondrial Function in Lung Health and Disease

Mitochondrial Function in Lung Health and Disease

Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and ...

Author: Viswanathan Natarajan

Publisher: Springer

ISBN: 9781493908295

Category: Medical

Page: 222

View: 657

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
Categories: Medical

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases.

Author: Sajal Chakraborti

Publisher: Springer Nature

ISBN: 9789813293663

Category: Science

Page: 488

View: 485

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.
Categories: Science

Cellular Signal Transduction in Toxicology and Pharmacology

Cellular Signal Transduction in Toxicology and Pharmacology

Notch signaling in lung diseases: focus on Notch1 and Notch3. Ther. Adv. Respir. Dis. 10 (5): 468–484. 13 Barnes, P.J. (2016). Kinases as novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Pharmacol. Rev.

Author: Jonathan W. Boyd

Publisher: John Wiley & Sons

ISBN: 9781119060161

Category: Science

Page: 336

View: 991

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques
Categories: Science

New Drugs and Targets for Asthma and COPD

New Drugs and Targets for Asthma and COPD

Hansel TT, Barnes PJ (eds): New Drugs and Targets for Asthma and COPD. ... Gq and G12/13 is thus able to signal via a number of signaling pathways (including PLC/PKC, MAPK, JNK and NF-B pathways) to mediate pluripotent cellular effects ...

Author: T.T. Hansel

Publisher: Karger Medical and Scientific Publishers

ISBN: 9783805595674

Category: Medical

Page: 324

View: 115

Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.
Categories: Medical

Pharmacology for Pharmacy and the Health Sciences

Pharmacology for Pharmacy and the Health Sciences

Like erlotinib it has also been associated with interstitial lung disease, and it can cause visual disturbances. Drugs targeting tumour intracellular pathways: tyrosine kinase inhibitors ...

Author: Michael Boarder

Publisher: Oxford University Press

ISBN: 9780198728832

Category:

Page: 712

View: 509

Pharmacology for Pharmacy and the Health Sciences introduces pharmacology in a way that is tailored to the needs of pharmacy and health care students. It provides an understanding of drug action at the cellular and molecular level, which is interfaced seamlessly with an explanation of the clinical use of drugs to treat common conditions. Taking a novel patient-centred approach, the book features a series of embedded workbooks which explore clinical topics in the context of individual patients and their experience of illness, and so relate the scientific basis of pharmacology to real-life pharmacy practice. The workbooks help you to interpret presenting symptoms, hospital clinical clerking, and patient history notes, and to understand the therapeutic strategy and clinical outcome, all within a simple reader-friendly format. Pharmacology for Pharmacy and the Health Sciences is the perfect course companion for anyone needing to develop a solid understanding of pharmacology and its impact on pharmacy and clinical practice. Online Resource Centre The Online Resource Centre to accompany Pharmacology for Pharmacy and the Health Sciences features: For registered adopters: - Figures from the book, available to download - PDF versions of all workbooks appearing in the text - Suggested answers to questions posed within the workbooks
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