The Glutamate Receptors

The Glutamate Receptors

An exciting primer to the study of glutamate receptors and their central role in neurotransmission, The Glutamate Receptors covers the extraordinary research and significant developments in the decade since the previous books were published ...

Author: Robert W. Gereau

Publisher: Springer Science & Business Media

ISBN: 9781597450553

Category: Medical

Page: 576

View: 431

This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.
Categories: Medical

Ionotropic Glutamate Receptors Trafficking in Health and Disease

Ionotropic Glutamate Receptors Trafficking in Health and Disease

The knowledge about the properties and importance of ionotropic glutamate receptor trafficking is ever increasing. Importantly, the pace of the progress has been accelerated in recent years.

Author: Milos Petrovic

Publisher: Frontiers Media SA

ISBN: 9782889450893

Category: Electronic book

Page:

View: 532

The knowledge about the properties and importance of ionotropic glutamate receptor trafficking is ever increasing. Importantly, the pace of the progress has been accelerated in recent years. Here, our contributors provide a) reviews on specific topics that present an up-to-date overview of the field, as well as b) original articles with the relevant new findings.
Categories: Electronic book

Glutamate Receptors Advances in Research and Application 2013 Edition

Glutamate Receptors   Advances in Research and Application  2013 Edition

The editors have built Glutamate Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about N-Methyl-D-Aspartate Receptors in this book to be ...

Author:

Publisher: ScholarlyEditions

ISBN: 9781481675970

Category: Medical

Page: 153

View: 373

Glutamate Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about N-Methyl-D-Aspartate Receptors. The editors have built Glutamate Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about N-Methyl-D-Aspartate Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glutamate Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Medical

Glutamate Receptors Advances in Research and Application 2011 Edition

Glutamate Receptors  Advances in Research and Application  2011 Edition

Glutamate Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Glutamate Receptors.

Author:

Publisher: ScholarlyEditions

ISBN: 9781464929212

Category: Medical

Page: 123

View: 771

Glutamate Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Glutamate Receptors. The editors have built Glutamate Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glutamate Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glutamate Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Medical

Glutamate

Glutamate

The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery.

Author: J. Storm-Mathisen

Publisher: Elsevier

ISBN: 0080532578

Category: Medical

Page: 312

View: 678

The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).
Categories: Medical

Ionotropic Glutamate Receptors in the CNS

Ionotropic Glutamate Receptors in the CNS

With contributions by numerous experts

Author: Peter Jonas

Publisher: Springer Science & Business Media

ISBN: 9783662080221

Category: Medical

Page: 535

View: 736

With contributions by numerous experts
Categories: Medical

The Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors

It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research.

Author: P. Jeffrey Conn

Publisher: Humana Press

ISBN: 0896032914

Category: Medical

Page: 277

View: 467

It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.
Categories: Medical

Glutamate Receptors in Peripheral Tissue

Glutamate Receptors in Peripheral Tissue

When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage.

Author: Santokh Gill

Publisher: Springer Science & Business Media

ISBN: 9780306486449

Category: Medical

Page: 420

View: 747

Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.
Categories: Medical