Challenges and Conundrums in Cannabinoid Based Treatments for Epilepsy Syndromes and Associated Neurobehavioral Comorbidities

Challenges and Conundrums in Cannabinoid Based Treatments for Epilepsy Syndromes and Associated Neurobehavioral Comorbidities

M186 Sigma–Aldrich) or CB2 receptors (CB65 cat. 2663 Tocris). The total binding was estimated in the absence of the specific agonist, whereas non-specific binding was obtained in the presence of unlabeled GTPγS (100 μM).

Author: Dolores E. López García

Publisher: Frontiers Media SA

ISBN: 9782889719662

Category: Science

Page: 170

View: 367

Categories: Science

Naval Research Reviews

Naval Research Reviews

Blumberg , A.F. , and G.L. Mellor , 1987 : A description of a Mellor , G.L. , T. Ezer , and L.-Y. Oey , 1994 : The pressure three - dimensional coastal ocean circulation model . gradient conundrum of sigma coordinate ocean In : Three ...

Author:

Publisher:

ISBN: IND:30000090252564

Category: Naval research

Page:

View: 799

Categories: Naval research

The Sigma Protocol

The Sigma Protocol

was hardly a moral conundrum. You did whatever you could to stay alive.” Ben had never thought of his father as a young man, frightened and desperate. His mind reeled. His aunt Sarah had died before he was born, but he remembered his ...

Author: Robert Ludlum

Publisher: St. Martin's Press

ISBN: 9781429906708

Category: Fiction

Page: 528

View: 313

Now comes The Sigma Protocol, a new breakneck novel of intrigue, conspiracy, and terrifying deception. American investment banker Ben Hartman arrives in Zurich for a ski holiday, the first time he's been back to Switzerland since his twin brother died there in a tragic accident four years earlier. But his arrival in Zurich triggers something far more sinister than his brother's fate. When Ben chances upon Jimmy Cavanaugh, an old college friend, Cavanaugh promptly pulls out a gun and tries to kill him. In a matter of minutes, several innocent bystanders are dead - as well as Cavanaugh - and Ben has barely managed to survive. Plunged into an unspeakable nightmare, Hartman suddenly finds himself on the run. Department of Justice field agent Anna Navarro is being stalked around the world by a relentless killer, managing to survive the killer's attacks only by a combination of luck, skill and her own quick wits. These attacks are somehow related to her current assignment: investigating the sudden - and seemingly unrelated - deaths of a number of very old men throughout the world. The only thing that connects them is a file in the CIA archives, over a half-century old, marked with the same puzzling code word: SIGMA. But someone or something is always seemingly one step ahead of her, the survivors are rapidly dwindling, and her own life is in ever increasing danger. Brought together by accident, Ben and Anna soon realize that their only hope of survival lies with each other. Together they race to uncover the diabolical secrets long hidden behind the code word, Sigma. Secrets that threaten everything they think they know about themselves, everything they believed true about their friends and families, and everything they were ever taught about history itself. For behind Sigma lies a vast deception that is finally coming to fruition and the fate and future of the world is in their hands.
Categories: Fiction

Ocean Forecasting

Ocean Forecasting

Mellor,G. L., T. Ezer and L. Y. Oey, 1994: The pressure gradient conundrum of sigma coordinate ocean models. J. Atmos. Oceanic. Technol., 11, 1126–1134. Mellor, G.L. andT. Yamada, 1974: A hierarchy of turbulence closure models for ...

Author: Nadia Pinardi

Publisher: Springer Science & Business Media

ISBN: 9783662226483

Category: Science

Page: 472

View: 786

The Advanced Study Courses in the field of Marine Science and Technology were part of the training programme developed from 1989 until 1999 within MAST, the Marine Science and Technology Programme of the European Union. They were related to the core topics of MAST Programme, marine systems research, extreme marine environments, regional Sea research, coastal systems research and engineering, and marine technology. The main objectives of these study courses were to further advance education in topics at the forefront of scien tific and technological development in Europe, and to improve the communication between students and experienced scientists on a European and international level. Over the years the Programme sponsored around 30 Advanced Study Courses. They took place in ten different member states of the European Union and their contribution in the formation of a European scientific community was significant. They also encouraged exchanges and contacts with several countries around the world such as United States, the third Mediterranean countries and others. The Course on Ocean Forecasting was one ofthe most successful with regard to its con tent, number of applications for participation and students satisfaction. When considering the need for the Advanced Study Course on Ocean Forecast ing, it is important to remember that the Oceans and Seas have always played a central role throughout the history of mankind. This is seen from the times of the ancient civilizations ofEgypt and Greece with the Phoenician traders, to the Viking voyages of exploration and discovery in medieval times.
Categories: Science

The Sigma Chi Quarterly

The Sigma Chi Quarterly

The Official Organ of the Sigma Chi Fraternity ... It has been a standing conundrum to those who know him how he finds time to do all that he does , Immediately upon leaving college he studied law and then spent two ...

Author:

Publisher:

ISBN: NYPL:33433076001803

Category: Greek letter societies

Page: 464

View: 272

Categories: Greek letter societies

Modern Approaches to Data Assimilation in Ocean Modeling

Modern Approaches to Data Assimilation in Ocean Modeling

Modeling vertical and horizontal diffusivities with the sigma coordinate system. Monthly Weather Review, 113, 1380-1383. Mellor, G. L., and T. Ezer. 1991. ... The pressure gradient conundrum of sigma coordinate ocean models.

Author: P. Malanotte-Rizzoli

Publisher: Elsevier

ISBN: 0080536662

Category: Science

Page: 452

View: 770

The field of oceanographic data assimilation is now well established. The main area of concern of oceanographic data assimilation is the necessity for systematic model improvement and ocean state estimation. In this respect, the book presents the newest, innovative applications combining the most sophisticated assimilation methods with the most complex ocean circulation models. Ocean prediction has also now emerged as an important area in itself. The book contains reviews of scientific oceanographic issues covering different time and space scales. The application of data assimilation methods can provide significant advances in the understanding of this subject. Also included are the first, recent developments in the forecasting of oceanic flows. Only original articles that have undergone full peer review are presented, to ensure the highest scientific quality. This work provides an excellent coverage of state-of-the-art oceanographic data assimilation.
Categories: Science

Numerical Models of Oceans and Oceanic Processes

Numerical Models of Oceans and Oceanic Processes

The pressure gradient conundrum of sigma coordinate ocean models. J. Atmos. Oceanic Technol. 11, 1126–1134. Mellor, G. L., and T. Azer. 1995. Sea level variations induced by heating and cooling: An evaluation of the Boussinesq ...

Author: Lakshmi H. Kantha

Publisher: Elsevier

ISBN: 9780080512907

Category: Science

Page: 750

View: 828

Oceans play a pivotal role in our weather and climate. Ocean-borne commerce is vital to our increasingly close-knit global community. Yet we do not fully understand the intricate details of how they function, how they interact with the atmosphere, and what the limits are to their biological productivity and their tolerance to wastes. While satellites are helping us to fill in the gaps, numerical ocean models are playing an important role in increasing our ability to comprehend oceanic processes, monitor the current state of the oceans, and to a limited extent, even predict their future state. Numerical Models of Oceans and Oceanic Processes is a survey of the current state of knowledge in this field. It brings together a discussion of salient oceanic dynamics and processes, numerical solution methods, and ocean models to provide a comprehensive treatment of the topic. Starting with elementary concepts in ocean dynamics, it deals with equatorial, mid-latitude, high latitude, and coastal dynamics from the perspective of a modeler. A comprehensive and up-to-date chapter on tides is also included. This is followed by a discussion of different kinds of numerical ocean models and the pre- and post-processing requirements and techniques. Air-sea and ice-ocean coupled models are described, as well as data assimilation and nowcast/forecasts. Comprehensive appendices on wavelet transforms and empirical orthogonal functions are also included. This comprehensive and up-to-date survey of the field should be of interest to oceanographers, atmospheric scientists, and climatologists. While some prior knowledge of oceans and numerical modeling is helpful, the book includes an overview of enough elementary material so that along with its companion volume, Small Scale Processes in Geophysical Flows, it should be useful to both students new to the field and practicing professionals. * Comprehensive and up-to-date review * Useful for a two-semester (or one-semester on selected topics) graduate level course * Valuable reference on the topic * Essential for a better understanding of weather and climate
Categories: Science

Observations and Modeling of the Internal Tide in a Submarine Canyon

Observations and Modeling of the Internal Tide in a Submarine Canyon

... and L.-Y. Oey , The pressure gradient conundrum of sigma coordinate ocean models , J. Atmos . Oceanic Technol . , 11 , 1126-1134 , 1994 . Mellor , G.L. , and T. Yamada , Development of 173.

Author: Emil T. Petruncio

Publisher:

ISBN: UCSD:31822023943376

Category: Internal waves

Page: 181

View: 201

Shipboard ADCP and CTD measurements were conducted in Monterey Submarine Canyon in April and October 1994 to determine the propagation characteristics and energy levels of the semidiurnal internal tide. The measurements reveal a bottom intensified internal tide propagating energy up canyon. The region of strongest motion is in a beam 150-200 m thick, centered approximately 150 m above the Canyon floor. Along canyon baroclinic M2 currents are typically 15-20 cm/s, an order of magnitude larger than the estimated barotropic tidal currents. In April 1994, the internal tidal beam is well described by a progressive wave, while in October 1994, the signal is standing along and perpendicular to the beam. The Princeton Ocean Model was used to study the generation and propagation of semidiurnal internal tides in submarine canyons and to investigate their sensitivity to canyon shape.
Categories: Internal waves

The Prometheus Deception The Sigma Protocol

The Prometheus Deception The Sigma Protocol

He approached the issue as yet another fieldwork conundrum to be solved; in his mind, he had worked out dozens of ingenious methods of entry. Yet all of them carried risks without commensurate odds of success.

Author: Robert Ludlum

Publisher: St. Martin's Griffin

ISBN: 9781429993739

Category: Fiction

Page: 1072

View: 851

Prometheus Deception Robert Ludlum is the acknowledged master of suspense and international intrigue. For over thirty years, in over twenty international bestsellers, he has a set a standard that has never been equaled. Now, with the Prometheus Deception, he proves that he is at the very pinnacle of his craft. Nicholas Bryson spent years as a deep cover operative for the American secret intelligence group, the Directorate. After critical undercover mission went horribly wrong, Bryson was retired to a new identity. Years later, his closely held cover is cracked and Bryson learns that the Directorate was not what it claimed - that he was a pawn in a complex scheme against his own country's interests. Now, it has become increasingly clear that the shadowy Directorate is headed for some dangerous endgame - but no one knows precisely who they are and what they are planning. With Bryson their only possible asset, the director of the CIA recruits Bryson to find, reinfiltrate, and stop the Directorate. But after years on the sidelines, Bryson's field skills are rusty, his contacts unreliable, and his instincts suspect. With everything he thought he knew about his own life in question, Bryson is all alone in a wilderness of mirrors - unsure what is and isn't true and who, if anyone, he can trust - with the future of millions in the balance. Sigma Protocol Ben Hartman is vacationing in Zurich, Switzerland when he chances upon his old friend Jimmy Cavanaugh—a madman who's armed and programmed to assassinate. In a matter of minutes, six innocent bystanders are dead. So is Cavanaugh. But when his body vanishes, and his weapon mysteriously appears in Hartman's luggage, Hartman is plunged into an unfathomable nightmare... Meanwhile, Anna Navarro, field agent for the Department of Justice, has been asked to investigate the sudden, random deaths of eleven men throughout the world. The only thing that connects them? A secret file, over a half-century old, that's linked to the CIA—and is marked with the same puzzling codename: Sigma. As Anna follows the connecting thread—and Hartman finds himself on the run—she ends up in the shadows of a relentless killer who is one step ahead of her...victim by victim. Now, she and Hartman together must uncover the diabolical secrets long held behind Sigma. It will threaten everything they think they know about themselves—and confirm their very worst fears...
Categories: Fiction

Computational Methods for the Atmosphere and the Oceans

Computational Methods for the Atmosphere and the Oceans

The pressure gradient conundrum of sigma coordinate ocean models. J. Atmos. Ocean. Technol. 11, 1126–1134. Mellor, G.L., Oey, L.-Y., Ezer, T. (1998). Sigma coordinate pressure gradient errors and the seamount problem. J. Atmos. Ocean.

Author:

Publisher: Elsevier

ISBN: 0080931030

Category: Computers

Page: 784

View: 659

This book provides a survey of the frontiers of research in the numerical modeling and mathematical analysis used in the study of the atmosphere and oceans. The details of the current practices in global atmospheric and ocean models, the assimilation of observational data into such models and the numerical techniques used in theoretical analysis of the atmosphere and ocean are among the topics covered. • Truly interdisciplinary: scientific interactions between specialties of atmospheric and ocean sciences and applied and computational mathematics • Uses the approach of computational mathematicians, applied and numerical analysts and the tools appropriate for unsolved problems in the atmospheric and oceanic sciences • Contributions uniquely address central problems and provide a survey of the frontier of research
Categories: Computers