The Telomerase Revolution

The Telomerase Revolution

The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

Author: Michael Fossel

Publisher: BenBella Books, Inc.

ISBN: 9781941631706

Category: Science

Page: 256

View: 835

One of Wall Street Journal’s "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells. But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
Categories: Science

Aging is a Group Selected Adaptation

Aging is a Group Selected Adaptation

The Green Revolution [89,90] has increased grain yields per acre by five- or ten-
fold since the 19th century. ... Fossel, M., The Telomerase Revolution: The
Enzyme That Holds the Key to Human Aging... and Will Soon Lead to Longer,
Healthier ...

Author: Joshua Mitteldorf

Publisher: CRC Press

ISBN: 9781315354033

Category: Medical

Page: 243

View: 719

Although books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.
Categories: Medical

Finding the Fountain of Youth The Science and Controversy behind Extending Life and Cheating Death

Finding the Fountain of Youth  The Science and Controversy behind Extending Life and Cheating Death

... Secrets of Your Telomeres for a Longer, Healthier Life (2010); and The
Telomerase Revolution (2015). For many years, he served as the founding editor
of the Journal of Anti-aging Medicine (later titled Rejuvenation Research and
edited by ...

Author: Aharon W. Zorea Ph.D.

Publisher: ABC-CLIO

ISBN: 9781440837999

Category: Psychology

Page: 389

View: 517

Separating truth from hype, this book introduces readers to the topic of life extension in a holistic manner that provides scientific, historical, and cultural perspectives. • Examines the topic of extending human life in a holistic, unbiased manner, exploring the subject from a variety of perspectives and contexts • Provides readers with additional insights into current controversies and debates related to the subject • Includes sidebars that offer additional high-interest, ready-reference content as well as a list of resources, a bibliography, and an index
Categories: Psychology

The Personalized Medicine Revolution

The Personalized Medicine Revolution

As a result, the study of telomeres has become a central feature of aging
research because it suggests that the reason you get old and die is because your
telomeres get shorter as you get older, resulting in more senescent cells that don'
t ...

Author: Pieter Cullis

Publisher: Greystone Books

ISBN: 9781771640398

Category: Health & Fitness

Page: 176

View: 561

Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level — a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it — despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn’t our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome — as well as its cousins proteomics, metabolomics, microbiomics, and the like — and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine — prediction, prevention, diagnosis, treatment, and monitoring — and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.
Categories: Health & Fitness

The Rise of Science

The Rise of Science

Press, Carlton, Victoria, Australia Fossel M (2015) The Telomerase Revolution.
BenBella Books, Dallas Freely J (2012) Before Galileo: The Birth of Modern
Science in Medieval Europe. Overlook Duckworth, London, UK Gamble C,
Gowlett J ...

Author: Peter Shaver

Publisher: Springer

ISBN: 9783319918129

Category: Science

Page: 279

View: 956

How did science rise up to so dramatically change our world, and where will it take us in the future? This book gives a unique and broad overview. A brief history reveals the major phases and turning points in the rise of science from the earliest civilizations to the present: How was science ‘discovered’? Why did it disappear a few times? When did it become ‘modern’? A critical assessment examines how science actually ‘happens’: the triumphs, the struggles, the mistakes and the luck. Science today is endlessly fascinating, and this book explores the current exponential growth, curiosity-driven vs. goal-oriented research, big and small science, the support of science, the relation of science to society, philosophy and religion, and the benefits and dangers of science. Finally a glimpse into the future: Will the current pace of science continue? Will we ever go backwards (again)? What remains to be discovered? Can science ever be complete? What can we imagine for the distant future? This book will be of wide interest to the general reader as well as to students and working scientists. This book provides a fresh, unique and insightful coverage of the processes of science, its impact on society and our understanding of the world, based on the author’s experience gained from a lifetime in science. Ron Ekers, FRS, CSIRO Fellow, CSIRO Astronomy & Space Science, former President of the International Astronomical Union Peter Shaver's comprehensive and lively survey deserves a wide readership. Scientific discoveries are part of our global culture and heritage, and they underpin our lives. It's fascinating to learn how they were made, and how they fit into the grand scheme. This book isn't just for scientists - it's written for all of us. Martin Rees, FRS, Astronomer Royal, former President of the Royal Society and former Master of Trinity College, Cambridge This book offers a wonderfully concise and accessible insight into science – its history, breadth and future prospects. Peter Shaver gives a feeling for what it actually means to be a practicing scientist. Stephen Simpson, FRS, Academic Director, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
Categories: Science

Men s Health the Hormone Revolution

Men s Health   the Hormone Revolution

Besides the telomerase enzyme and the chemical wear - and - tear caused by
free oxygen radicals , are there any other mechanisms controlling the fate of cells
? Can this biophysical process be influenced by hormones in a way that would ...

Author: Siegfried Meryn

Publisher: Richmond Hill, ON : NDE Pub.

ISBN: CORNELL:31924073880464

Category: Aging

Page: 318

View: 916

This controversial guide explores how aging affects a man's life & how hormones play a pivotal role in mental fitness, stress, mid-life crises, & virility.
Categories: Aging

Annals of the Academy of Medicine Singapore

Annals of the Academy of Medicine  Singapore

They are ( 1 ) age and ageing , ( 2 ) alternative medicine , ( 3 ) AIDS , ( 4 ) the
human genome and ( 5 ) the information revolution . ( a ) The Telomere Story
One of the most exciting research in ageing has resulted from the genetic study of
a ...

Author: Academy of Medicine (Singapore)


ISBN: UCLA:L0088703616



View: 426


Lung Cancer An Issue of Clinics in Chest Medicine E Book

Lung Cancer  An Issue of Clinics in Chest Medicine   E Book

Technologic Revolution Has Allowed Genome-Wide Analyses of Molecular
Changes Occurring in Lung Cancer Chronic ... Activation of telomerase (the
telomere-lengthening enzyme required for cell immortality) and disruption or
escape from ...

Author: Lynn T. Tanoue

Publisher: Elsevier Health Sciences

ISBN: 9781455709717

Category: Medical

Page: 311

View: 450

Carcinoma of the lung is one of the most prevalent and aggressive types of cancer, and rates of lung cancer are on the rise. This issue gives a comprehensive review of the most recent advances in Lung Cancer. Epidemiology, etiology, and prevention of lung cancer is first discussed, followed by articles on pre-invasive evaluation and management, screening, pathology and molecular biology. There is an article on the approach to the ground glass nodule. Of great importance is the revised staging classification of Lung Cancer, which is discussed here in detail. Articles on PET imaging, interventional pulmonary, and functional evaluation before Lung Resection are also included. The issue then focuses on advances in treatment for early stage lung cancer, high risk patients with early stage lung cancer, advances in the treatment of Advanced Stage Lung Cancer, Small Cell Lung Cancer, and gene therapy for lung neoplasms.
Categories: Medical

Inhibition of Telomerase from Human Ovarian Cancer Cells Via the Stabalization of G quadruplex Structures by Various Chemotheraputic Agents

Inhibition of Telomerase from Human Ovarian Cancer Cells Via the Stabalization of G quadruplex Structures by Various Chemotheraputic Agents

I wanted to be a part of the scientific revolution that is still occurring every time
breakthroughs are made in understanding life ' s code . I hoped to have a positive
impact on that revolution . The machine of scientific discovery has its big gears ...

Author: Paul Edrick Schutt


ISBN: UOM:49015002777838


Page: 50

View: 412


In Vivo

In Vivo

3 Banks DA , Fossel M : Telomeres , cancer , and aging , altering the human
lifespan . JAMA 278 ... Vaziri H : Extension of Life Span in Normal Human Cells
by Telomerase Activation : A Revolution in Culhlral Senescence . Journal of Anti



ISBN: UCLA:L0090608001



View: 502


The next genesis

The next genesis

“All right, I can understand this. Perhaps we will also train our adult population
with Prosis, allowing them to also participate in your revolution. They have the
experience we need. I can make no guarantees, but I will recommend it to the

Author: Kimberly Coghlin

Publisher: Transmedia Press

ISBN: 9781935805533

Category: Liberty

Page: 472

View: 783

Categories: Liberty

Liberation Biology

Liberation Biology

The Scientific and Moral Case for the Biotech Revolution Ronald Bailey. gives
them a big jolt of telomerase . ” 34 The dendritic cells , which now display the
telomerase protein , are injected back into a patient as a vaccine . Like all
vaccines ...

Author: Ronald Bailey


ISBN: UOM:39015061445949

Category: Science

Page: 332

View: 359

An examination of the future of biology and what it will mean for humanity looks at the possibilities that recent scientific advances have made possible and discusses the ethical implications of the sciences of the future.
Categories: Science

Full Catastrophe Living Revised Edition

Full Catastrophe Living  Revised Edition

The third recent revolution in science and medicine came with the discovery of
telomeres and the enzyme telomerase that repairs the telomeres. Telomeres are
structures at the ends of all of our chromosomes that are necessary for our cells
to ...

Author: Jon Kabat-Zinn

Publisher: Bantam

ISBN: 9780345539724

Category: Self-Help

Page: 720

View: 555

The landmark work on mindfulness, meditation, and healing, now revised and updated after twenty-five years Stress. It can sap our energy, undermine our health if we let it, even shorten our lives. It makes us more vulnerable to anxiety and depression, disconnection and disease. Based on Jon Kabat-Zinn’s renowned mindfulness-based stress reduction program, this classic, groundbreaking work—which gave rise to a whole new field in medicine and psychology—shows you how to use medically proven mind-body approaches derived from meditation and yoga to counteract stress, establish greater balance of body and mind, and stimulate well-being and healing. By engaging in these mindfulness practices and integrating them into your life from moment to moment and from day to day, you can learn to manage chronic pain, promote optimal healing, reduce anxiety and feelings of panic, and improve the overall quality of your life, relationships, and social networks. This second edition features results from recent studies on the science of mindfulness, a new Introduction, up-to-date statistics, and an extensive updated reading list. Full Catastrophe Living is a book for the young and the old, the well and the ill, and anyone trying to live a healthier and saner life in our fast-paced world. Praise for Full Catastrophe Living “To say that this wise, deep book is helpful to those who face the challenges of human crisis would be a vast understatement. It is essential, unique, and, above all, fundamentally healing.”—Donald M. Berwick, M.D., president emeritus and senior fellow, Institute for Healthcare Improvement “One of the great classics of mind/body medicine.”—Rachel Naomi Remen, M.D., author of Kitchen Table Wisdom “A book for everyone . . . Jon Kabat-Zinn has done more than any other person on the planet to spread the power of mindfulness to the lives of ordinary people and major societal institutions.”—Richard J. Davidson, founder and chair, Center for Investigating Healthy Minds, University of Wisconsin–Madison “This is the ultimate owner’s manual for our lives. What a gift!”—Amy Gross, former editor in chief, O: The Oprah Magazine “I first read Full Catastrophe Living in my early twenties and it changed my life.”—Chade-Meng Tan, Jolly Good Fellow of Google and author of Search Inside Yourself “Jon Kabat-Zinn’s classic work on the practice of mindfulness to alleviate stress and human suffering stands the test of time, a most useful resource and practical guide. I recommend this new edition enthusiastically to doctors, patients, and anyone interested in learning to use the power of focused awareness to meet life’s challenges, whether great or small.”—Andrew Weil, M.D., author of Spontaneous Happiness and 8 Weeks to Optimum Health “How wonderful to have a new and updated version of this classic book that invited so many of us down a path that transformed our minds and awakened us to the beauty of each moment, day-by-day, through our lives. This second edition, building on the first, is sure to become a treasured sourcebook and traveling companion for new generations who seek the wisdom to live full and fulfilling lives.”—Diana Chapman Walsh, Ph.D., president emerita of Wellesley College
Categories: Self-Help

Reversing Human Aging

Reversing Human Aging

24 A clinically effective telomerase inhibitor should be available well within ten
years and ... Scientific , medical , and public discussions will focus on the
therapeutic possibilities and the social effects of this revolution . From time to time
, we will ...

Author: Michael Fossel

Publisher: Quill

ISBN: 0688153844

Category: Health & Fitness

Page: 160

View: 819

Explains the effects of aging on the human body and describes groundbreaking medical advances in age reversal, citing their potential cures for cancer, heart disease, Alzheimer's, and stroke
Categories: Health & Fitness

Russ Coile s Health Care Forecast

Russ Coile s Health Care Forecast

GenomOn the far side of the technology , new genetic discov ics offers the
possibility of treating the root ( genetic ) eries hold out the promise of “ anti - aging
" " The Quiet Genetics Revolution : treatments one day . Isolation of telomerase ...

Author: Russell C. Coile


ISBN: 0834218720

Category: Hospitals

Page: 106

View: 182

Categories: Hospitals

Reversal of Aging

Reversal of Aging

In both senescence and crisis , expression of telomerase ( hTERT ) leads directly
to an immortal state , demonstrating ... Ronald Klatz calls this nothing less than a
longevity revolution , and he cites as evidence the advances brought about in ...

Author: Walter Pierpaoli


ISBN: UVA:X030000979

Category: Aging

Page: 574

View: 907

The body of research on the process of human aging has grown considerably in recent years, and the reports presented here explore a full range of approaches to this research, from the molecular and genetic to the cellular and organismic levels. The contributing scientists identify the processes of aging and find functional and mechanistic approaches that may delay, prevent, or arrest the progress of aging and those ailments generally linked to senescence, such as metabolic, cardiovascular, and autoimmune diseases. The investigation of various approaches to the prevention of aging will include efforts to mitigate the deleterious consequences of chemical pollution.
Categories: Aging

The Big Bang and Relative Immortality

The Big Bang and Relative Immortality

... of stem cells which may serve to regenerate organs; and the discovery of
telomeres and telomerase which may be the long-hunted secret of death — these
constitute a revolution in biology rivaling the discovery of the microbial world.

Author: Sebastian Sisti

Publisher: Algora Publishing

ISBN: 0875866085

Category: Health & Fitness

Page: 131

View: 709

This series of brief and sparkling philosophical essays explores the Principle of Continuity as it impacts discussions of the Big Bang and the expansion of the universe, God, infinity, biological immortality and evolution. From Ancient Greece to the frontiers of modern science, some egregious blunders have been made in both philosophy and in theoretical physics. The old theory of Continuous Creation was blown up by the Big Bang theory, but the author shows that this is just another ontological quagmire that conflicts with the First Law of Thermodynamics (conservation)OCoand common sense. Surveying scientific principles, he discerns where they can and cannot illuminate our understanding."
Categories: Health & Fitness

Biotechnology and the Future of Society

Biotechnology and the Future of Society

reproduction , the fuse ( the telomere ) gets shorter and shorter , until it
disappears and the chromosome disintegrates . ... This new green revolution by
itself will not be able to feed the growing populations in the Third World , but it
may help to ...

Author: Emirates Center for Strategic Studies & Research

Publisher: I.B. Tauris

ISBN: 9948005082

Category: Science

Page: 320

View: 111

Breakthroughs in biotechnology are redefining the very concept of life, transforming society and presenting unprecedented opportunities and challenges: will human genome sequencing help to treat genetic diseases and indefinitely prolong life? Can nature's workshops inspire superior biomaterials that transform industries? Will genetically modified super crops feed a hungry world? With biotechnology set to be the driving force of the twenty-first century, mastery of the life sciences will be the key to wealth generation and economic ascendancy. Can the Arab world regain its past supremacy in these fields? Can it benefit from the biotech revolution while avoiding its perils? These essays examine the complex ethical, legal and social issues raised by the biotech revolution that need to be resolved by governments and decision makers.
Categories: Science